DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SV2C and CG31103

DIOPT Version :9

Sequence 1:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens
Sequence 2:	NP_001097914.1	Gene:	CG31103 / 43030	FlyBaseID:	FBgn0051103	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	122/583 - (20%)
Similarity:	222/583 - (38%)	Gaps:	116/583 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   138 YELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMM 202
            |::::::.|:|:.||.|..|.|:..:........:..::.:::.:.....:..|.:.:....|:.
  Fly    17 YDMVLEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIF 81

Human   203 VGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFA 267
            :..:.||.::|.:||::.||.....:....|:..||.....|....||.|..:|.....:::|.:
  Fly    82 LSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAVSAALYAYLS 146

Human   268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVS 332
            |......|...:::..||..:..||..|.||.::.. .|:.:||. :.|..||:.::|..||...
  Fly   147 EFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSS-NWAITMGD-FVFRPWRLLLLVSLLPGFI 209

Human   333 SVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIES 397
            ..:.|.:.||||:|||...|::||                 .|.|..::|....|.|.:::..:.
  Fly   210 GGLILLYYPESPKFLLSQEKNNEA-----------------IEAVAWISKFNRGKSIQQVLSCDE 257

Human   398 DTGTWYRRCFVRIRTELYGIWLTFMRC------FNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPD 456
            .|..........:..|..|..:....|      |:.|...|.|...:..|.:.|...|:.:|||:
  Fly   258 FTLKSEDPVGENLLGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSSNGMQLWFPE 322

Human   457 VIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCT 521
            :               |.|...|        ||                            .|.|
  Fly   323 I---------------VNRSSGA--------EN----------------------------NSST 336

Human   522 FEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586
            ..::.||.....|.|   ...|.||  |             ..:||               |..|
  Fly   337 VCEILSVPVEQPNVT---ETLDCTD--P-------------ISSKT---------------YIDN 368

Human   587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY---NGLTI 648
            .:...|.|.|..:..|:::.:||..:|..::.::.:|...|.|..|.:.::.:.|||   .||:|
  Fly   369 LVVGFAFLIGFSIQGLILNPLGRKNVLLAALAVATLSGVLLHFMESPTGVLVLFCLYILLPGLSI 433

Human   649 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS-ITKSIPILLASTVLVC 710
            |.   :....|:|.||..|:....|..:|.:...:....:.|.::. ...:...:...|::||
  Fly   434 SI---MIGAIVDLVPTHLRSKAVSFCMSLGRLGIIAATNLMGVMLQPYCNTTFAMFTCTLIVC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	122/583 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	116/566 (20%)
		Pentapeptide_3	507..561	CDD:290309	10/53 (19%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		10/43 (23%)
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	116/551 (21%)
CG31103	NP_001097914.1	MFS	34..>189	CDD:119392	30/155 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920