Protein Alignment DIP2C and DIP2

DIOPT Version :10

• Sequence 1: XP_054221234.1
• Gene: DIP2C / 22982
• HGNCID: 29150
• Length: 1626
• Species: Homo sapiens
• Sequence 2: NP_612019.2
• Gene: DIP2 / 252479
• FlyBaseID: FBgn0024806
• Length: 1773
• Species: Drosophila melanogaster
• Alignment Length: 1803
• Identity: 946/1803 - (52%)
• Similarity: 1177/1803 - (65%)
• Gaps: 263/1803 - (14%)

Human    33 GDITQKGYEKKRSKLIGAYL-----------PQPPTAN----------------GAAVVRCRLQH 70
            ||||||||||||:||:..:|           |.||..|                |..|      .
  Fly    25 GDITQKGYEKKRAKLLQPFLKKPEGDKVKSTPPPPYYNVKNANNSTNHGNINNDGVIV------S 83

Human    71 SEGAPRRT-------FRSAHIGVCDVREAAARE-RVASTAGN--RPLFYFRFGVDQALP------ 119
            |||....|       .:..|....|..:.||.. ..|..:||  .|      |.:...|
  Fly    84 SEGYSYVTEVPSLSSSQQRHSKKIDFHQQAAMSLSSAPQSGNAGAP------GYENMRPQGGAVG 142

Human   120 ----QERRAPVT----PSSASRYHRRRSSGSR----DERYRSDVHTEAVQAALAKHKER-KMAVP 171
                |..|.|..    .|:.:..||:|.:..:    ::||.|:|..||||.|||..|.| |.::|
  Fly   143 DPGYQNTREPSAFQNQQSTNNSQHRQRRTQRKVTHNEKRYHSEVRQEAVQQALAALKGRPKPSLP 207

Human   172 MPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSS-----QGSINMEHWISQAIHGS 231
            |||||.|::           :.|.|..||.....|.:..|..:     :.:...:| ||.:|...
  Fly   208 MPSKRTSVL-----------NRSPGCNDELDSSTDDESIPEETISPDKEYNYPRDH-ISNSILPP 260

Human   232 TTSTTSSSSTQSGGSGAAHRLADVMAQTHIEN------HSAP----------------------- 267
            ...........|.|| ..|...|| .|..|.|      :|||
  Fly   261 EPIIKPPIRESSMGS-QQHARTDV-KQNQITNQKYTAPNSAPERRPPQNLPPLPTSEPLSSDYPP 323

Human   268 ---------------------PDVTTYTSEHSIQVERPQGSTGSRTAPKYGNA---ELMET-GDG 307
                                 ||:|.:.:.|          ..:....:|.|.   ||.|| .:|
  Fly   324 IAYKRENDFSDKAFKQKQYNAPDITQFNNAH----------RAADRVTRYVNVSQNELNETDANG 378

Human   308 VPVSSRVSAKIQQLVNTLKRPKRPPLREFFVD-DFEELLEVQQPDPNQPKPEGAQMLAMRGEQLG 371
               ..:||||||||:||||||||.||.||:.| |.|..:.....|||.|||||:.|..::||||.
  Fly   379 ---KWKVSAKIQQLLNTLKRPKRRPLPEFYEDNDIELEIAANTKDPNAPKPEGSTMTPVQGEQLS 440

Human   372 VVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYSILHKLGTK--Q 434
            :....|.:||.||||:||.|.|:|..|.:|.|||....||||||.:|:.|:|:::..|:.:|  :
  Fly   441 IPAGLPRTLECALQRYGTNSFKSPMATVLDPNGKVTTTLTYGKLLSRAQKIAHALSTKIFSKGPE 505

Human   435 EPMVRPGDRVALVFPNNDPAAFMAAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVA 499
            :..::||||||||:|||||.:|:.|:|||:...:||:|||:||:..|...||:||||.|||:|||
  Fly   506 QVTLKPGDRVALVYPNNDPLSFITAWYGCMFRGLVPLPIELPLSSSDTPPQQVGFLLSSCGITVA 570

Human   500 LTSDACHKGLPKS-PTGEIPQFKGWPKLLWFVTESKHLSKPPRDW-FPHIKDANNDTAYIEYKTC 562
            |||:||.|||||| .||||.:.||||:|.|||||  ||.|||::: ..:::..::..|||||.|.
  Fly   571 LTSEACLKGLPKSTTTGEIAKLKGWPRLQWFVTE--HLPKPPKEFNVGNLRADDSAAAYIEYTTD 633

Human   563 KDGSVLGVTVTRTALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPY 627
            |:|||:||||||.|::.||:|||.||.|||.||||.|||||::|||||.:||||:|.||||.|||
  Fly   634 KEGSVMGVTVTRAAMINHCRALTMACHYTEGETIVCVLDFKREVGLWHSVLTSVLNGMHVIFIPY 698

Human   628 SLMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCD 692
            :|||:.|.||:|.:.:::|....|||||:||.|:|.:|.:||:|||||||:|||||||||:||||
  Fly   699 ALMKLRPSSWMQLITKHRASCCLVKSRDLHWGLLATKDHKDISLSSLRMLLVADGANPWSLSSCD 763

Human   693 AFLNVFQSKGLRQEVICPCASSPEALTVAIRRP----TDDSNQPPGRGVLSMHGLTYGVIRVDSE 753
            .||:|||:||||.:.|||||||.|..||::|||    ...|....|||||||..|::||:|||||
  Fly   764 QFLSVFQAKGLRSDAICPCASSSEVFTVSLRRPGRGSCGFSPSATGRGVLSMAALSHGVVRVDSE 828

Human   754 EKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEIGELCVCAVATGTSYYGLSGMTKNTFEVF 818
            :.|:.||:||.|.|||.|.|..|:.:|.|.||:||::||:||.:.:|..||:||.|||.:||:|.
  Fly   829 DSLTSLTLQDCGQVMPAAQMVVVRSEGPPVLCKTDQVGEICVTSGSTSASYFGLDGMTNSTFKVQ 893

Human   819 PMTSS--------------GAPISEYPFIRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDI 869
            |:...              ..||.|..::|:|||||:||||||||.|..||||.|:||:||||||
  Fly   894 PLLEELEQPKDGNGTVNIISKPIGEDFYVRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKHNADDI 958

Human   870 VATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGV 934
            :||.||||||:|:|||||||||:.||.|||:.::||||||.:||:|||||||||||:|||||||:
  Fly   959 IATVLAVEPMRFIYRGRIAVFSIKVLRDERVCVIAEQRPDCSEEESFQWMSRVLQAVDSIHQVGI 1023

Human   935 YCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQ----------- 988
            |||||||.|.|||||||||||.|.::.||||||||.|||||||||||||||||:
  Fly  1024 YCLALVPPNHLPKTPLGGIHLCEARRRFLEGSLHPANVLMCPHTCVTNLPKPRELHQGVQTAAKL 1088

Human   989 --------KQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPD 1045
                    ....:|||||||||||.|.|:|:|.|||:|..||.:  ||...::.||:|||.|:||
  Fly  1089 SSSSGCGITDTGVGPASVMVGNLVQGNRLAEAHGRDVGLAEDCE--RKPQLITGVLRWRANTSPD 1151

Human  1046 HILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYA 1110
            ||::||||.:||||.:|||.:|||||||||.:|.|||.::.||||||::|||:||:.|||||||.
  Fly  1152 HIIFTLLNSKGAIAKTLTCSELHKRAEKIAALLQERGRIEPGDHVALIFPPGLDLLCAFYGCLYL 1216

Human  1111 GCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRTWPLILDTD 1175
            |.:|||:|||||||:.||||||:|||:||:|..:::.|.|.|||:|||||.::|.:|||.|||.|
  Fly  1217 GAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGIVLSIQPIIKLLKSREAATSIDPKTWPPILDID 1281

Human  1176 DLPKKRPAQICKPCNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICL 1240
            |.||::.|.|. ..:.|:.|||||||||.|.|:||.::|.:.|:.|.|:||.|||||||.||:||
  Fly  1282 DNPKRKYAGIA-TVSFDSSAYLDFSVSTCGRLSGVNITHRSLSSLCASLKLACELYPSRHVALCL 1345

Human  1241 DPYCGLGFVLWCLCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGS 1305
            |||||||||:|.|..|||||.||||.|.|:|.||:|||..:||::||||||||.|:|||||.|.:
  Fly  1346 DPYCGLGFVMWTLIGVYSGHHSILIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSN 1410

Human  1306 QTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQPH 1370
            ...|||.|.:||..|||||||||||||:.|||.|.|||:.|||:.|.||||||||||.|||:
  Fly  1411 SIPSLKQRNIDLRCVRTCVVVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICV--- 1472

Human  1371 RLWTLAEQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGP 1435
                   ||.|..:...|||||||||::||.|||||:|:||.::||||:||||::|||||||||.
  Fly  1473 -------QGASSAESAQVYVDMRALRNNRVALVERGAPNSLCVIESGKLLPGVKVIIANPETKGH 1530

Human  1436 LGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTE----- 1495
            .||||||||||.:.|||:|||||||||:..:||||::|..|.|..::|||||||||||||
  Fly  1531 CGDSHLGEIWVQAPHNANGYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTECSQSA 1595

Human  1496 ----------------------------------------------LTDANG-ERHDALYVVGAL 1513
                                                          .::||. |.|||:|||||:
  Fly  1596 SLLDETTPSVASRDSDTESLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAV 1660

Human  1514 DEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLE 1578
            ||.:.||||.|||||||.||:|.||.:.|||||||||||||||||||:|.|||||||||||.|||
  Fly  1661 DEVISLRGMNYHPIDIENSVMRCHKKIAECAVFTWTNLLVVVVELDGNESEALDLVPLVTNTVLE 1725

Human  1579 EHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1626
            :|.||||||||||.||:|||||||||||||||||||||||||||||||
  Fly  1726 DHQLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLDPIYVAYNM 1773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP2C	XP_054221234.1	DMAP_binding	<32..178	CDD:368923	62/200 (31%)
		Dip2	396..972	CDD:341231	357/597 (60%)
		Dip2	1048..1622	CDD:341231	389/625 (62%)
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:368923	28/95 (29%)
		ARG80	33..369	CDD:227400	83/371 (22%)
		Dip2	465..1061	CDD:341231	357/597 (60%)
		Dip2	1154..1769	CDD:341231	389/625 (62%)