DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FOXD4 and FoxK

DIOPT Version :9

Sequence 1:	NP_997188.2	Gene:	FOXD4 / 2298	HGNCID:	3805	Length:	439	Species:	Homo sapiens
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	96/346 - (27%)
Similarity:	143/346 - (41%)	Gaps:	88/346 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    76 PSDPSEFGTE-----FRAPPRSAAASEDARQPAKPPSSYIALITMAILQSPHKRLTLSGICAFIS 135
            |::.:.:|..     |:.|   :.||.:..:  |||.||..||..||..:|.|:||||||.:||.
  Fly   425 PNNYNNYGNNNTQDLFQTP---STASYNHNE--KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIV 484

Human   136 DRFPYYRRKF-PAWQNSIRHNLSLNDCFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKR 199
            ..:||||::. ..||||||||||||..|:|:.|....||||::|.:||.|.....:.|:.:||:|
  Fly   485 KHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR 549

Human   200 -FQRHQPTPGAHLPHPFPLPAAHAALHNPRPGPLLGAPAPPQPVPGAYPNTGPGRRPYALLHPHP 263
             .|..:|..|  :|...|:..:|  :.|.|..      :|.|.:
  Fly   550 SSQGFRPPYG--MPRSAPVSPSH--MDNSRES------SPLQDI--------------------- 583

Human   264 PRYLLLSAPAYAGAPKKAEGADLATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVSCK 328
               :|.|||...|...:...||           |.::.: .:.|...::.::.......|   ..
  Fly   584 ---VLQSAPGSPGMSLEQRAAD-----------PEIIYN-SQNAHQQQQQQQQQQQQQTL---SN 630

Human   329 GSGERVQGL-RRVCPRPRGATAPCSSDRQACRTILQQQQRHQEEDCANG----------CAPTKG 382
            .|.:...|. ..|..:..|...|               |.|.|...|:|          .|..:.
  Fly   631 NSNQYSSGSPYYVTNQSSGVATP---------------QTHVEGSAASGGGGGGGVGALLALKRN 680

Human   383 AVLGGHLSAASALLRYQAVAE 403
            .|:||..| ...|.:.||||:
  Fly   681 HVMGGGAS-QHTLHQQQAVAQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOXD4	NP_997188.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..104		6/32 (19%)
		Forkhead	104..189	CDD:306709	46/85 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232		7/28 (25%)
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	46/86 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850