Protein Alignment PAXIP1 and paxip1

DIOPT Version :10

• Sequence 1: NP_031375.3
• Gene: PAXIP1 / 22976
• HGNCID: 8624
• Length: 1069
• Species: Homo sapiens
• Sequence 2: XP_021335681.1
• Gene: paxip1 / 449658
• ZFINID: ZDB-GENE-041010-214
• Length: 1136
• Species: Danio rerio
• Alignment Length: 1140
• Identity: 737/1140 - (64%)
• Similarity: 848/1140 - (74%)
• Gaps: 91/1140 - (7%)

Human     1 MSDQAPKVPEEMFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREV 65
            ||:...|||||:|::||:|.|||||.:|:||||:||.|||||||||:|||:||||||||||:|||
Zfish     1 MSEDDLKVPEELFKDVKFYVVGDIDQKVVQLLKSGKGKEVSYNALATHIIAEDGDNPEVGESREV 65

Human    66 FDLPVVKPSWVILSVQCGTLLPVNGFSPESCQIFFGITACLSQVSSEDRSALWALVTFYGGDCQL 130
            |||||||||||||||:||.||||.||||||.|:|||:||||..: :||.:||||.:|||||||||
Zfish    66 FDLPVVKPSWVILSVKCGDLLPVTGFSPESGQVFFGVTACLPHL-AEDLNALWAFITFYGGDCQL 129

Human   131 TLNKKCTHLIVPEPKGEKYECALKRASIKIVTPDWVLDCVSEKTKKDEAFYHPRLIIYEEEEEEE 195
            ..|||||||:||||||.||||||:..:||||||:|:||.|.||.:|||..|||||.:|:..|||.
Zfish   130 HFNKKCTHLVVPEPKGAKYECALRHNNIKIVTPEWILDSVKEKNRKDEMLYHPRLTLYDAPEEEG 194

Human   196 EEEEEVENEEQDSQNEGSTDE-------KSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFDDSS 253
            .|.|    .|:.|::|||..:       :|||.||::.||:|.:  ||.:..|: |.|||||||.
Zfish   195 SEYE----NERSSRSEGSYSDRRSPHSRRSSPTSSRDASPAGRR--SPSTKHER-KSELMFDDSD 252

Human   254 DSSPEKQERNLNWTPAEVPQLAAAKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQN 318
            ||||||::||||||||||.....|||||..|||.||||||||||||||:..||:.|.....||..
Zfish   253 DSSPEKEDRNLNWTPAEVLPPGPAKRRLQPGKETGLINLCANVPPVPGSFGPPDARMVGAGAGGG 317

Human   319 L-QSSERSEMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKN-LEQQVNHSQQGH 381
            : ...||.|:::.|:.|.|||||||||.|.||.:||||||||:|:.||.:|. ::...|..|.|.
Zfish   318 VPMGVERLEVMSEWNSAARTLRNITNNTDTQQPSRPSNVAHIIQSFSASSKGVVDHMGNQGQSGI 382

Human   382 TNANAVLFSQVKVTPE-------------THMLQQQQQAQQQQQQHPVL---------HLQPQQI 424
            .| ..:|.:|.::.||             :|.||||||..|..||||::         |.|.||.
Zfish   383 PN-QLLLKAQQQLPPEAQQQLLQQQQQQQSHQLQQQQQQHQMAQQHPMMLPQVMQMHHHQQQQQH 446

Human   425 MQLQQQQQQQISQQPYPQQPP--HPFSQQQQQQQQAHPHQFSQQQLQFPQQQLHP-PQQLHRPQQ 486
            ....||||||.:||.:||.||  |.|.|||..||....||..|||.|..|||.|. |||: ||||
Zfish   447 QPPPQQQQQQQNQQGFPQMPPQSHQFLQQQMHQQMYSQHQQQQQQQQQQQQQQHAFPQQM-RPQQ 510

Human   487 ----QLQPFQQQHALQQQFHQLQQH----QLQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQ 543
                .|| .||||.||||....|||    ||||||..|.|||.   |||||||.||||.|:..||
Zfish   511 LPRLPLQ-HQQQHVLQQQLQLQQQHRLQLQLQQQQQQQQQQQQ---QQQQQQQQQQQQKQQQQQQ 571

Human   544 QQQQQMQSQTAPHLSQTSQALQHQVPPQQPPQQQQQQQPPPSPQQH------------------- 589
            |.||||..|   ||.|....||.|:..|...|.|||||.....|||
Zfish   572 QNQQQMHQQ---HLQQQQHFLQQQLQQQHMQQLQQQQQMQQQQQQHLQNQQPLQHQNQQVNPHQT 633

Human   590 -----------QLFGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQLLATWKRIIQAHGGTVDPT 643
                       |||||:|..:|||||||:||:||||||||||:|||||||||||||.:|||||..
Zfish   634 QTMLQPPITSAQLFGHEPGHDIPEEGFLVGCIFAIADYPEQMADKQLLATWKRIIQLNGGTVDSA 698

Human   644 FTSRCTHLLCESQVSSAYAQAIRERKRCVTAHWLNTVLKKKKMVPPHRALHFPVAFPPGGKPCSQ 708
            . :||||||||||||:.|.||:||.|||||||||||||||||||||||.||.|.:||||.|||:|
Zfish   699 L-NRCTHLLCESQVSNTYLQALREGKRCVTAHWLNTVLKKKKMVPPHRTLHLPFSFPPGAKPCAQ 762

Human   709 HIISVTGFVDSDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPTGLKYEKAKEWRIPCVNAQWLG 773
            |||||||||||||||||||||||||:|||||||||||||||||:||||||||||||||||||||.
Zfish   763 HIISVTGFVDSDRDDLKLMAYLAGARYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPCVNAQWLC 827

Human   774 DILLGNFEALRQIQYSRYTAFSLQDPFAPTQHLVLNLLDAWRVPLKVSAELLMSIRLPPKLKQNE 838
            ||||||||||||||:|:||.|:|.||.||..|||.|||.|||:|:|:|.|.|.|:||..|.||.:
Zfish   828 DILLGNFEALRQIQHSKYTQFNLPDPLAPNHHLVHNLLSAWRIPVKISPEALASLRLQLKQKQAD 892

Human   839 VANVQPSSKRARIEDVPPPTKKLTPELTPFVLFTGFEPVQVQQYIKKLYILGGEVAESAQKCTHL 903
            | :|||.|||.::|::|.|||||.|:.||:||||||||:|.||||||||.||||||:|.||||||
Zfish   893 V-SVQPPSKRPKLEELPTPTKKLPPDSTPYVLFTGFEPLQAQQYIKKLYDLGGEVADSTQKCTHL 956

Human   904 IASKVTRTVKFLTAISVVKHIVTPEWLEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAH 968
            :|:||||||||||||||||||||||||||.::.|||:|||:|:||||||||||||||||||||||
Zfish   957 VANKVTRTVKFLTAISVVKHIVTPEWLEESWKSQKFVDEQSYMLRDAEAEVLFSFSLEESLKRAH 1021

Human   969 VSPLFKAKYFYITPGICPSLSTMKAIVECAGGKVLSKQPSFRKLMEHKQNSSLSEIILISCENDL 1033
            .:||||.|||||||||||||||||.|||.|.|||||||||:||:||||||.:|.|||||:||||.
Zfish  1022 AAPLFKGKYFYITPGICPSLSTMKLIVESAAGKVLSKQPSYRKIMEHKQNKNLPEIILITCENDS 1086

Human  1034 HLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKF 1068
            |||||||.:.|:|:.||.:|||||||:||||||.|
Zfish  1087 HLCREYFLKNIEVYTAELILTGVLTQSLDYESYPF 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAXIP1	NP_031375.3	BRCT_PAXIP1_rpt1	13..87	CDD:349346	59/73 (81%)
		Interaction with PAGR1. /evidence=ECO:0000250	94..183		60/88 (68%)
		BRCT_PAXIP1_rpt2	98..178	CDD:349342	54/79 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..271		44/89 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..494		39/72 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..592		24/78 (31%)
		Interaction with TP53BP1	590..1069		379/479 (79%)
		BRCT_PAXIP1_rpt3	608..689	CDD:349343	66/80 (83%)
		Nuclear localization signal. /evidence=ECO:0000255	702..719		14/16 (88%)
		BRCT_PAXIP1_rpt4	709..781	CDD:349362	68/71 (96%)
		BRCT_PAXIP1_rpt5	866..940	CDD:349344	61/73 (84%)
		BRCT_PAXIP1_rpt6	972..1062	CDD:349393	69/89 (78%)
paxip1	XP_021335681.1	BRCT_PAXIP1_rpt1	13..87	CDD:349346	59/73 (81%)
		BRCT_PAXIP1_rpt2	98..177	CDD:349342	54/79 (68%)
		BRCT_PAXIP1_rpt3	663..743	CDD:349343	66/80 (83%)
		BRCT_PAXIP1_rpt4	763..835	CDD:349362	68/71 (96%)
		BRCT_PAXIP1_rpt5	919..993	CDD:349344	61/73 (84%)
		BRCT_PAXIP1_rpt6	1025..1115	CDD:349393	69/89 (78%)