Protein Alignment PAXIP1 and Paxip1

DIOPT Version :10

• Sequence 1: NP_031375.3
• Gene: PAXIP1 / 22976
• HGNCID: 8624
• Length: 1069
• Species: Homo sapiens
• Sequence 2: XP_063142007.1
• Gene: Paxip1 / 311944
• RGDID: 1307547
• Length: 1117
• Species: Rattus norvegicus
• Alignment Length: 1133
• Identity: 932/1133 - (82%)
• Similarity: 974/1133 - (85%)
• Gaps: 80/1133 - (7%)

Human     1 MSDQAPKVPEEMFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREV 65
            ||:.||:||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSEPAPEVPEELFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREV 65

Human    66 FDLPVVKPSWVILSVQCGTLLPVNGFSPESCQIFFGITACLSQVSSEDRSALWALVTFYGGDCQL 130
            |||||||||||.||||||||||||||||||||||||:|||||||||||||||||||||:||.|||
  Rat    66 FDLPVVKPSWVTLSVQCGTLLPVNGFSPESCQIFFGLTACLSQVSSEDRSALWALVTFHGGSCQL 130

Human   131 TLNKKCTHLIVPEPKGEKYECALKRASIKIVTPDWVLDCVSEKTKKDEAFYHPRLIIYEEEEEEE 195
            .|||||||||||||||||||.|:||.|||||||||||||||||.:||||.|||||||||||||||
  Rat   131 NLNKKCTHLIVPEPKGEKYERAVKRTSIKIVTPDWVLDCVSEKRRKDEASYHPRLIIYEEEEEEE 195

Human   196 EEEEEVENEEQDSQNEGSTDEKSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFDDSSDSSPEKQ 260
            |||.  :||||||||||||| |||.|||.|.||: ||..|||:..|.||||||||||||||||||
  Rat   196 EEEG--DNEEQDSQNEGSTD-KSSAASSAEASPA-DQPCSPKARAEVSKGELMFDDSSDSSPEKQ 256

Human   261 ERNLNWTPAEVPQLAAAKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQNLQSSERS 325
            ||:|||.|||.|.|:.|:.||||||.|||||||||||||||:||||::||||||||||||||||.
  Rat   257 ERSLNWAPAEAPPLSTAQHRLPQGKGPGLINLCANVPPVPGDILPPDMRGNLMAAGQNLQSSERP 321

Human   326 EMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKNLEQQVNHSQQGHTNANAVLFS 390
            ||:.||||||||||||||||||||::||||||||||:||||||||||||.|.||||.:|:||||.
  Rat   322 EMLGTWSPAVRTLRNITNNADIQQISRPSNVAHILQSLSAPTKNLEQQVAHVQQGHPSASAVLFG 386

Human   391 QVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQLQQQQQQQISQ-QPYPQQPPHPFSQQQQQ 454
            |.|..||||.|||....||.|||||.||||| ||||||||||||..| |||||.|.|.|
  Rat   387 QAKGAPETHTLQQHHPPQQPQQQHPALHLQP-QIMQLQQQQQQQQQQPQPYPQPPSHQF------ 444

Human   455 QQQAHPHQFSQQQLQFPQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQLQQQQLAQLQQ 519
            .||.|.|||||||||||||.|||.||||||||||||||||||||||.|||||.||||.|||||||
  Rat   445 PQQVHQHQFSQQQLQFPQQPLHPQQQLHRPQQQLQPFQQQHALQQQLHQLQQQQLQQHQLAQLQQ 509

Human   520 QHSLLQQQQQ---QQIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQHQVPPQQP-------- 573
            |....||||.   ||.|||||||:|   ||||||:|.| |||||||||||||.||||
  Rat   510 QQQQQQQQQHNLLQQQQQQQLQRLH---QQQQMQNQAA-HLSQTSQALQHQVLPQQPLQLPLQPP 570

Human   574 --PQQQQQQQPPPSPQQHQLFGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQLLATWKRIIQAH 636
              .|||||||.....||.||||||||||||||.||||||||||||||||||||||||||||||||
  Rat   571 PQQQQQQQQQQQQQQQQQQLFGHDPAVEIPEESFLLGCVFAIADYPEQMSDKQLLATWKRIIQAH 635

Human   637 GGTVDPTFTSRCTHLLCESQVSSAYAQAIRERKRCVTAHWLNTVLKKKKMVPPHRALHFPVAFPP 701
            |||||||||||||||||||||||.||||:||||||||||||||||||||::||||||||||||||
  Rat   636 GGTVDPTFTSRCTHLLCESQVSSMYAQALRERKRCVTAHWLNTVLKKKKLMPPHRALHFPVAFPP 700

Human   702 GGKPCSQHIISVTGFVDSDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPTGLKYEKAKEWRIPC 766
            |||||||||||||||||:||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   701 GGKPCSQHIISVTGFVDNDRDDLKLMAYLAGAKYTGYLCRSNTVLICKEPSGLKYEKAKEWRIPC 765

Human   767 VNAQWLGDILLGNFEALRQIQYSRYTAFSLQDPFAPTQHLVLNLLDAWRVPLKVSAELLMSIRLP 831
            |||||||||||||||||||:||||||||:|.|||.||.||||:||||||.|:||:||||||||||
  Rat   766 VNAQWLGDILLGNFEALRQVQYSRYTAFNLPDPFVPTPHLVLSLLDAWRTPVKVTAELLMSIRLP 830

Human   832 PKLKQNEVANVQPSSKRA----------------------------------------------- 849
            ||||.|||||:|| ||||
  Rat   831 PKLKPNEVANIQP-SKRARGWRDVIKSTDYSCRGPGFSSQHPHDSSQLPVTSVLCRHWAMHMVHR 894

Human   850 ---RIEDVPPPTKKLTPELTPFVLFTGFEPVQVQQYIKKLYILGGEVAESAQKCTHLIASKVTRT 911
               ||||:|||||||||||||:||||||||||||||||||||||||||||.:|||||||||||||
  Rat   895 HTCRIEDLPPPTKKLTPELTPYVLFTGFEPVQVQQYIKKLYILGGEVAESTKKCTHLIASKVTRT 959

Human   912 VKFLTAISVVKHIVTPEWLEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKAK 976
            ||||||||||||||||:||||||:.|.||||||||||||||||||||||||||||||||||||.|
  Rat   960 VKFLTAISVVKHIVTPDWLEECFKRQMFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPLFKTK 1024

Human   977 YFYITPGICPSLSTMKAIVECAGGKVLSKQPSFRKLMEHKQNSSLSEIILISCENDLHLCREYFA 1041
            ||||||||||||:||||||||||||||:||||||||||||||.||||||||||||||||||||||
  Rat  1025 YFYITPGICPSLATMKAIVECAGGKVLAKQPSFRKLMEHKQNKSLSEIILISCENDLHLCREYFA 1089

Human  1042 RGIDVHNAEFVLTGVLTQTLDYESYKFN 1069
            ||||||||||||||||||||||||||||
  Rat  1090 RGIDVHNAEFVLTGVLTQTLDYESYKFN 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAXIP1	NP_031375.3	BRCT_PAXIP1_rpt1	13..87	CDD:349346	72/73 (99%)
		Interaction with PAGR1. /evidence=ECO:0000250	94..183		78/88 (89%)
		BRCT_PAXIP1_rpt2	98..178	CDD:349342	70/79 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..271		64/82 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..494		49/66 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..592		35/58 (60%)
		Interaction with TP53BP1	590..1069		447/528 (85%)
		BRCT_PAXIP1_rpt3	608..689	CDD:349343	76/80 (95%)
		Nuclear localization signal. /evidence=ECO:0000255	702..719		16/16 (100%)
		BRCT_PAXIP1_rpt4	709..781	CDD:349362	69/71 (97%)
		BRCT_PAXIP1_rpt5	866..940	CDD:349344	66/73 (90%)
		BRCT_PAXIP1_rpt6	972..1062	CDD:349393	85/89 (96%)
Paxip1	XP_063142007.1	None