DRSC/TRiP Functional Genomics Resources

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Protein Alignment PAXIP1 and brc1

DIOPT Version :10

Sequence 1:NP_031375.3 Gene:PAXIP1 / 22976 HGNCID:8624 Length:1069 Species:Homo sapiens
Sequence 2:NP_001417957.1 Gene:brc1 / 2541071 PomBaseID:SPBC582.05C Length:849 Species:Schizosaccharomyces pombe


Alignment Length:597 Identity:122/597 - (20%)
Similarity:198/597 - (33%) Gaps:223/597 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   673 TAHW-LNTVLKKKKMVPPHRALHFPVAFPPGGKPCSQHIISVTGFVDSDRDDLKLMAYLAGAKYT 736
            |..| ||..:......|...|||:|  ||..|. ....:::||.:.|:.|..|:.:....||.||
pombe   256 TISWLLNLFVLGSWKSPLLNALHYP--FPSVGF-LKDQMVAVTNYTDAARIYLEKLLLACGATYT 317

Human   737 GYLCRSNTVLICKEPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQIQYSRYTAF------- 794
            ..|..:||:||.....|.||..||.|.||.|:..||       :.:.:.:....:|.|       
pombe   318 KDLKPTNTLLIAASSYGQKYGAAKVWNIPTVHHSWL-------YSSFKNLSSQAFTDFPVPLDDS 375

Human   795 -----------------------------------SLQDP-----------------FAPT---- 803
                                               .|.||                 |..|    
pombe   376 YMDFIFPCPLNVEKGSFEDTLKSSLTKGNSEVLLDDLSDPSVSSIKGNKTNEELEKEFKSTSDNF 440

Human   804 -QHLVL---------------------------------NLLDAWRV--------------PLKV 820
             :|::|                                 .|.|..|:              ||.|
pombe   441 GKHIILTSSFSNQSADKGSSLAAEDDRNDEGSTITGVNRELQDEGRLEIDAKSSKTNTPPSPLLV 505

Human   821 SAELLMSIR----------LPPKLKQNEVANVQPSSKRARI-----EDVPPPTKKLTPEL---TP 867
            ......|::          |..||..|.:....|.|...::     ::.....|||..||   .|
pombe   506 GTPSKESLKEASSDDELPVLATKLVDNVIKEKSPLSLTPKVVVPSHKETYTDEKKLIDELDRVNP 570

Human   868 ----------------------------------------------------------------- 867
                                                                             
pombe   571 LNSSQLLRSKRKSAATALSMLQNVIMPDVLAFEREKKRRQTHRSVSSGEVSRESSESRNTNAKAS 635

Human   868 ---FVLFTGFEPVQVQQYIKKLYILGGEVAESAQKCTHLIASKVTRTVKFLTAISVVKHIVTPEW 929
               ::.|||::.......:|||.:   .:..:..|||||||.::.||.|||.:|.....:||.:|
pombe   636 KRVYITFTGYDKKPSIDNLKKLDM---SITSNPSKCTHLIAPRILRTSKFLCSIPYGPCVVTMDW 697

Human   930 LEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAHVS--PLFKAKYFYIT-PGICP-SLST 990
            :..|.:..:.:||:.|:|.|.|.|:....:||.:||||...  .|.:....|:| ..:.| ::..
pombe   698 INSCLKTHEIVDEEPYLLNDPEKELELGCTLESALKRARAQGPSLLEDYVVYLTSKTVAPENVPA 762

Human   991 MKAIVECAGGKVLSKQPSFRKLMEHKQNSSLSEIILISCENDLHLCREYF-----ARGIDVHNAE 1050
            :.:||:..||...:.....::|..|.::.:   ::||:|..|.|:...:.     .:.|.:.|.:
pombe   763 VISIVKSNGGVCSTLNVYNKRLARHLEDGN---VVLITCNEDSHIWTNFLDNASQNKTIFLQNYD 824

Human  1051 FVLTGVLTQTLD 1062
            :::..||.|.:|
pombe   825 WLIKTVLRQEID 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAXIP1NP_031375.3 BRCT_PAXIP1_rpt1 13..87 CDD:349346
Interaction with PAGR1. /evidence=ECO:0000250 94..183
BRCT_PAXIP1_rpt2 98..178 CDD:349342
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..494
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 543..592
Interaction with TP53BP1 590..1069 122/597 (20%)
BRCT_PAXIP1_rpt3 608..689 CDD:349343 4/16 (25%)
Nuclear localization signal. /evidence=ECO:0000255 702..719 3/16 (19%)
BRCT_PAXIP1_rpt4 709..781 CDD:349362 25/71 (35%)
BRCT_PAXIP1_rpt5 866..940 CDD:349344 24/141 (17%)
BRCT_PAXIP1_rpt6 972..1062 CDD:349393 20/96 (21%)
brc1NP_001417957.1 BRCT <5..75 CDD:469589
BRCT_BRC1_like_rpt2 81..155 CDD:349389
BRCT_BRC1_like_rpt3 195..272 CDD:349390 4/15 (27%)
BRCT_BRC1_like_rpt4 290..357 CDD:349391 25/73 (34%)
BRCT_BRC1_like_rpt5 638..705 CDD:349374 23/69 (33%)
BRCT_BRC1_like_rpt6 721..836 CDD:349392 27/117 (23%)
Blue background indicates that the domain is not in the aligned region.

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