Protein Alignment SIRT2 and Sirt1

DIOPT Version :10

• Sequence 1: NP_036369.2
• Gene: SIRT2 / 22933
• HGNCID: 10886
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 125/363 - (34%)
• Similarity: 196/363 - (53%)
• Gaps: 71/363 - (19%)

Human    30 GAAGGEAD---MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSA 91
            |.||...|   .|:|.:|.::.    .::.:|....|.:.|...:  ::.:::|.|.|||:|.|.
  Fly   178 GLAGDTDDSVLWDYLAHLLNEP----KRRNKLASVNTFDDVISLV--KKSQKIIVLTGAGVSVSC 236

Human    92 GIPDFRSPSTGLYDNLEKYH----LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFM 152
            ||||||| :.|:|..|.  |    ||.|:|:|:|:|||:.|.||:..|:|:|||:|:|:.||.|:
  Fly   237 GIPDFRS-TNGIYARLA--HDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFI 298

Human   153 RLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEV 217
            ::|:.||.|||.||||||||||:||:::  ::|.||:|.|:.|  ..||.:.....::..||::.
  Fly   299 KMLETKGKLLRNYTQNIDTLERVAGIQR--VIECHGSFSTASC--TKCRFKCNADALRADIFAQR 359

Human   218 TPKCEDCQ------------------------SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLL 258
            .|.|..||                        .::|||||||||.||..:.:.|.:|....|||:
  Fly   360 IPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLI 424

Human   259 VMGTSLQVQPFASLISKAPLSTPRLLINKEK----------AGQSDPFLGMIMGLGGGMDFDSKK 313
            |:|:||:|:|.|.:.|..|.:.|::|||:|:          .|.||..:..|.....    |:..
  Fly   425 VIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLS----DNDD 485

Human   314 AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHAS 351
            .:|.:.    ||:..|.         |.::|:..||::
  Fly   486 CWRQLC----CDESVLT---------ESKELMPPEHSN 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT2	NP_036369.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		2/3 (67%)
		Nuclear export signal	41..51		2/9 (22%)
		SIRT1	77..331	CDD:238699	111/291 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..389		0/1 (0%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	105/260 (40%)