Protein Alignment SEPHS1 and Sps2

DIOPT Version :10

• Sequence 1: NP_036379.2
• Gene: SEPHS1 / 22929
• HGNCID: 19685
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_477478.4
• Gene: Sps2 / 34397
• FlyBaseID: FBgn0032224
• Length: 370
• Species: Drosophila melanogaster
• Alignment Length: 376
• Identity: 160/376 - (42%)
• Similarity: 234/376 - (62%)
• Gaps: 14/376 - (3%)

Human     7 FNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRLGIGMDTC 71
            |.||.:.|:..|:||:||...|..||:||.||:|.|...:..:...|...:|:       |||..
  Fly     2 FQPEKHGLEPDFQLTKFTTHTGUSCKIPQKVLEKYLRGTEIENKNNDGYLIGS-------GMDCA 59

Human    72 VIPL-RHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDR 135
            |||| ||....|:||.|:.||:|:||.::||||.||||||:||:|||:.|.:.|::..|...:::
  Fly    60 VIPLKRHKDYLLIQTVDFFYPMVNDPELLGRIALANVLSDVYAVGVTQFDTVEMIVSTSTSFSEK 124

Human   136 ERDKVMPLIIQGFKDAAEEAG---TSVTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVL 197
            |||.|:.|:::||:::.:..|   |.:...|..:|||.::||:||:||:..|.|:|.||.|||||
  Fly   125 ERDVVIGLVMKGFQNSLKANGYRNTPLIIRQLKINPWCIIGGIATSVCRSEEIILPSNAQPGDVL 189

Human   198 VLTKPLGTQVAVAVHQW-LDIPEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAH 261
            |||||||.|:|:..|.| |:..||:.|:....:..|::..::.|:.:|..||:.||.|||.:.||
  Fly   190 VLTKPLGGQMAMDAHLWQLNQTEKYKKLLSECSDADIKETFEIAVKSMTYLNKNAALLMHKYQAH 254

Human   262 AATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLI 326
            .||||||||:||||.|||:.|:.:|.|.|:.||::..:...|...|.......|...||||||||
  Fly   255 CATDITGFGLLGHANNLAQFQKEKVLFQINKLPIIKNVLKFSTLVGQSTKFRSGRSVETSGGLLI 319

Human   327 CLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRT-ARIIDKPRIIEVA 376
            |||.:.|.:||.:.:....|| .:::.||.|...|.: |.:.:....|||:
  Fly   320 CLPADAADKFCRDFEEATNGE-QKSFQIGHVTAANESDAVLCEDVEFIEVS 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEPHS1	NP_036379.2	selD	19..333	CDD:273100	142/318 (45%)
Sps2	NP_477478.4	SelD	15..349	CDD:100031	149/341 (44%)