Protein Alignment MAPRE3 and CG18190

DIOPT Version :10

• Sequence 1: NP_036458.2
• Gene: MAPRE3 / 22924
• HGNCID: 6892
• Length: 281
• Species: Homo sapiens
• Sequence 2: NP_611384.2
• Gene: CG18190 / 37179
• FlyBaseID: FBgn0034403
• Length: 248
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 98/283 - (34%)
• Similarity: 151/283 - (53%)
• Gaps: 48/283 - (16%)

Human     1 MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQA 65
            :.:.|..|||.:||:||||||.|||:.:|.::.|||:|||||||||.|:|:||.|::|::||..|
  Fly     4 LKLTVALTSVNAENMSRHDMLQWVNNMVHGHFKKIEELCSGAAYCQMMEMIFPNCINLKRVKMTA 68

Human    66 KLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLAR 130
            ||||||:||.::.|.||.::.:||.:|:::|:||:|||||||:||||||||:...|.:....||.
  Fly    69 KLEHEYLHNLRLFQEAFNRLKLDKTVPIDRLIKGRFQDNFEFLQWFKKFFDSQAPGLENIKSLAN 133

Human   131 QGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGG 195
                 ||...|                                    :.|....::..|...|
  Fly   134 -----APLAKP------------------------------------IKPRQFAKERSPVNAN-- 155

Human   196 HETDAQILELNQQLVDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPV--ISGIIGILYAT 258
               |..:.||..::.:|.|..:.:.:..:..::|||.:|.:..:..:.|..|  ...|..:||.|
  Fly   156 ---DDALKELIDEMKNLSLKREDIMEASNQIYNKLRLVEDLVNDMINNNQLVELCKRIQAVLYKT 217

Human   259 EEGFAPPEDDEIEEHQQEDQDEY 281
            .:|....|..|:.|...::..|:
  Fly   218 IDGEINEEPVEVNEDNGDEGAEH 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPRE3	NP_036458.2	BIM1	16..279	CDD:227542	91/264 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..181		0/23 (0%)
		DCTN1-binding	217..281		14/65 (22%)
		APC-binding	217..260		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..281		4/19 (21%)
CG18190	NP_611384.2	BIM1	19..>124	CDD:227542	63/104 (61%)
		EB1	184..216	CDD:460870	8/31 (26%)