Protein Alignment MAPRE3 and Eb1

DIOPT Version :10

• Sequence 1: NP_036458.2
• Gene: MAPRE3 / 22924
• HGNCID: 6892
• Length: 281
• Species: Homo sapiens
• Sequence 2: NP_724495.2
• Gene: Eb1 / 35584
• FlyBaseID: FBgn0027066
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 155/301 - (51%)
• Similarity: 204/301 - (67%)
• Gaps: 32/301 - (10%)

Human     1 MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQA 65
            ||||||||:|||||||||||||||||.|...::|||:||:|||||||||||||..|.:::|||:.
  Fly     1 MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRT 65

Human    66 KLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLAR 130
            .||||||.|||:|||.||||.|||||||:||:||:|||||||:|||||||||||||::|:|:..|
  Fly    66 NLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQR 130

Human   131 QGQDV----APPPNPGDQIFNKSKKL------------IGTAVPQRTSPTGPKNMQTSGRLSNVA 179
            .|..:    ....|.|..:.:.:..|            .|..:|.|...:...: :...|.:|.|
  Fly   131 GGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVS-KVLPRTNNAA 194

Human   180 P-----PC-----ILRKNPPSARNGGHETDAQILELNQQLVDLKLTVDGLEKERDFYFSKLRDIE 234
            |     .|     .::||..|    ....:.||.|::.|::|:::.::|||||||||||||||||
  Fly   195 PASRINACANSTGTVKKNDVS----NSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIE 255

Human   235 LICQE-HESENSPVISGIIGILYATEEGFAPPEDDEIEEHQ 274
            ::||| .::|..|:|..|:.||||||:|||||:|...|:.:
  Fly   256 ILCQEADDAEAHPIIQKILDILYATEDGFAPPDDAPPEDEE 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAPRE3	NP_036458.2	BIM1	16..279	CDD:227542	141/286 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..181		6/28 (21%)
		DCTN1-binding	217..281		37/59 (63%)
		APC-binding	217..260		29/43 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..281		7/14 (50%)
Eb1	NP_724495.2	BIM1	16..293	CDD:227542	140/281 (50%)