DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAPRE3 and CG15306

DIOPT Version :9

Sequence 1:	NP_001289979.1	Gene:	MAPRE3 / 22924	HGNCID:	6892	Length:	281	Species:	Homo sapiens
Sequence 2:	NP_001259403.1	Gene:	CG15306 / 31961	FlyBaseID:	FBgn0030191	Length:	357	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	85/301 - (28%)
Similarity:	140/301 - (46%)	Gaps:	66/301 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     6 YSTSVTSENL---SRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKL 67
            ::.:||..:|   ||.|:|.|.|::|..|...|||||:|||||..|.||:|..::|::|||.:..
  Fly     7 HNVTVTHNSLVQWSRGDILDWFNETLQCNLINIEQLCTGAAYCNLMHMLYPKLINLKRVKFFSNQ 71

Human    68 EHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKD----YNPLL 128
            |:||::|||.||.||.|:.|.....|..|:||...:||:|..||:.||:.|:. ||    |:.|:
  Fly    72 EYEYVNNFKELQKAFNKVNVSLPAEVNDLIKGHRVENFKFAVWFRHFFNVNHT-KDKCAGYDALV 135

Human   129 ARQGQDVAPPPNPGDQIFNKSK----KLIGTAVPQRTSP----------TGPKNMQTSGRLSNVA 179
            ||..|::.   ....::..|.:    |:..||:..:.:.          ||..|.....:.::
  Fly   136 ARDHQNIG---IGSSKLTTKDRFRLVKVKTTAIRGKVATCQATINSSLCTGKANQDEDSQHTD-- 195

Human   180 PPCILRKNPPSARNGGHETDAQILELNQQLVDLKLTVDGLEKERDFYF-------SKLRDIELIC 237
                 :|:..|...|....|:.  .::.|..|.        :::|..:       |:.:|    |
  Fly   196 -----KKDEDSRDQGSQYEDSP--GMDSQYKDC--------RDQDSQYEDSHGKDSQYKD----C 241

Human   238 QEHESENSPVISGIIGILYATEEGF-APPEDDEIEEHQQED 277
            ::..|:            |....|. :..||...::.|.||
  Fly   242 RDQGSQ------------YEDSHGMDSQYEDSRDQDSQYED 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAPRE3	NP_001289979.1	BIM1	16..279	CDD:227542	82/288 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..181		3/33 (9%)
		DCTN1-binding	217..281		12/69 (17%)
		APC-binding	217..260		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281		6/18 (33%)
CG15306	NP_001259403.1	CH	20..103	CDD:278723	40/82 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810