DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAPRE1 and Eb1

DIOPT Version :9

Sequence 1:NP_036457.1 Gene:MAPRE1 / 22919 HGNCID:6890 Length:268 Species:Homo sapiens
Sequence 2:NP_724495.2 Gene:Eb1 / 35584 FlyBaseID:FBgn0027066 Length:297 Species:Drosophila melanogaster


Alignment Length:301 Identity:162/301 - (53%)
Similarity:207/301 - (68%) Gaps:37/301 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQA 65
            ||||||||:|||:||||||||||:|:.||...:|||:||:|||||||||||||.|:.:|:|||:.
  Fly     1 MAVNVYSTNVTSENLSRHDMLAWVNDCLQSQFSKIEELCTGAAYCQFMDMLFPNSVPVKRVKFRT 65

Human    66 KLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAAR 130
            .|||||||||||||||||:|.||||||||||:||:|||||||:|||||||||||||::|||||.|
  Fly    66 NLEHEYIQNFKILQAGFKKMSVDKIIPVDKLIKGRFQDNFEFLQWFKKFFDANYDGREYDPVAQR 130

Human   131 QGQE------------TAVAPS-----------LVAPAL--NKPKKPLTSSSAAPQRPISTQRTA 170
            .|.:            :.|..|           |.|||.  ..|.:.:.|::.:...| .|...|
  Fly   131 GGVKLGNGNGHGSNGGSGVGSSNNDLHLMHRRPLQAPASGGRMPARVIASTAVSKVLP-RTNNAA 194

Human   171 AAPKA-----GPGVVRKNPGVGN--GDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELIC 228
            .|.:.     ..|.|:|| .|.|  .:.:..|:..||..:::.:|.|||||||||.|||:||::|
  Fly   195 PASRINACANSTGTVKKN-DVSNSVNNQQIEEMSNQVMDMRINLEGLEKERDFYFSKLRDIEILC 258

Human   229 QE-NEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY 268
            || ::.|..|::|:|:||||||::||..||:..|  |.|||
  Fly   259 QEADDAEAHPIIQKILDILYATEDGFAPPDDAPP--EDEEY 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAPRE1NP_036457.1 BIM1 16..257 CDD:227542 142/273 (52%)
Interaction with MTUS2/TIP150. /evidence=ECO:0000269|PubMed:19543227 124..268 63/176 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..187 10/47 (21%)
Interaction with CDK5RAP2. /evidence=ECO:0000269|PubMed:19553473 185..268 40/85 (47%)
DCTN1-binding 208..268 35/60 (58%)
APC-binding 220..242 11/22 (50%)
Eb1NP_724495.2 BIM1 16..293 CDD:227542 145/280 (52%)
CH 16..114 CDD:278723 75/97 (77%)
EB1 241..279 CDD:281288 23/37 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158818
Domainoid 1 1.000 180 1.000 Domainoid score I3513
eggNOG 1 0.900 - - E1_COG5217
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 299 1.000 Inparanoid score I2716
Isobase 1 0.950 - 0 Normalized mean entropy S1295
OMA 1 1.010 - - QHG56844
OrthoDB 1 1.010 - - D1237523at2759
OrthoFinder 1 1.000 - - FOG0000490
OrthoInspector 1 1.000 - - otm41520
orthoMCL 1 0.900 - - OOG6_100898
Panther 1 1.100 - - LDO PTHR10623
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4252
SonicParanoid 1 1.000 - - X303
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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