DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CD93 and frac

DIOPT Version :9

Sequence 1:	NP_036204.2	Gene:	CD93 / 22918	HGNCID:	15855	Length:	652	Species:	Homo sapiens
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	152/637 - (23%)
Similarity:	201/637 - (31%)	Gaps:	227/637 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    37 YTAHSGKLS-----------AAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARM 90
            |...|||..           ::..|..|....|:...|:..||...:..|:...:.:...:...:
  Fly   323 YLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNV 387

Human    91 SKFWIGLQREKGKCLDPSLPLKGFSW---------VGGGED--------------------TPYS 126
            |:     .:..||..:....|.....         |.|.||                    |...
  Fly   388 SE-----SQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVE 447

Human   127 NWH-KELRNSCISKRCVSLLLDLSQPLLP--------SRLPKWS--------------------- 161
            .:| .|.:.||....|.    ||..|.|.        ..||:.|
  Fly   448 GYHLLEDQRSCALDSCT----DLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQ 508

Human   162 EGPCG--------SPGS---------------PGSNIEGFVCK-----FSFKGMCRPLALGGPGQ 198
            |.||.        |||:               .|...|.|.|:     .....:|.......||.
  Fly   509 ESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGG 573

Human   199 VTYTTP----------------FQTTSSSLEAVPFASAANV-ACGEGDKDETQSHYFLCKEKAPD 246
            .....|                .:..::..|.:...:...| ||.||
  Fly   574 YQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREG------------------ 620

Human   247 VFDWGSSGPLCVSPKYGCNFNNGGCHQDC------------------------------------ 275
             |...:.|..|.... .|..|||||.|.|
  Fly   621 -FRLSADGKSCEDVD-ECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQR 683

Human   276 ---------FEGGDGSFLCGCRPGFRL-LDDLV---------------------TCASRNPCSSS 309
                     .|..:||:.|.|.||:.| ||:.:                     ||...:.||.:
  Fly   684 THGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLA 748

Human   310 PCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDS--PCAQECVNTPGGFRCECWVG 372
            .......|...|.|  :.|.||.||.|......|.|:|||.||  .|:|.|:|.||||.|.|..|
  Fly   749 NGNCSHFCQNEPGG--FQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETG 811

Human   373 YE--PGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVG-- 433
            :|  |.|.|   |.|:|||:.....|:..|.|..|:..|:||.||.|| :|...|.|||||.|
  Fly   812 FELTPDGFG---CADIDECSQDYGNCSDICINLLGTHACACERGYELA-KDKLSCLDVDECAGLL 872

Human   434 PGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEED 485
            .||  |...|.|..|:|.|||..|::|..:|.||:  |..:|.|.|.....|
  Fly   873 SGG--CSHECINKAGTFECGCPLGYILNDDGRSCS--PALVGCPPGTQRSAD 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CD93	NP_036204.2	CLECT_thrombomodulin_like	31..184	CDD:153070	42/244 (17%)
		FXa_inhibition	264..300	CDD:317114	18/102 (18%)
		cEGF	326..348	CDD:315355	8/21 (38%)
		EGF_CA	345..>369	CDD:214542	15/25 (60%)
		EGF_CA	385..425	CDD:311536	16/39 (41%)
		EGF_CA	427..468	CDD:214542	20/42 (48%)
		WTX	<464..>549	CDD:312801	8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..546		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..652
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	4/7 (57%)
		cEGF	396..415	CDD:289433	1/18 (6%)
		FXa_inhibition	425..458	CDD:291342	3/32 (9%)
		FXa_inhibition	476..505	CDD:291342	3/28 (11%)
		vWFA	<550..586	CDD:294047	5/35 (14%)
		FXa_inhibition	596..630	CDD:291342	8/52 (15%)
		FXa_inhibition	636..>664	CDD:291342	8/27 (30%)
		EGF_CA	676..715	CDD:284955	10/38 (26%)
		FXa_inhibition	745..780	CDD:291342	11/36 (31%)
		FXa_inhibition	786..821	CDD:291342	18/37 (49%)
		FXa_inhibition	827..862	CDD:291342	13/35 (37%)
		FXa_inhibition	874..904	CDD:291342	13/31 (42%)
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010