Protein Alignment SACM1L and SAC1

DIOPT Version :10

• Sequence 1: NP_001306000.1
• Gene: SACM1L / 22908
• HGNCID: 17059
• Length: 609
• Species: Homo sapiens
• Sequence 2: NP_012710.1
• Gene: SAC1 / 853668
• SGDID: S000001695
• Length: 623
• Species: Saccharomyces cerevisiae
• Alignment Length: 584
• Identity: 211/584 - (36%)
• Similarity: 322/584 - (55%)
• Gaps: 32/584 - (5%)

Human    18 FYVEACDDGADD-VLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKV 81
            |:..|...|.:| |:.:......|.:...::.|.......|..::|.|.|....|.|:.....:.
Yeast    15 FFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEET 79

Human    82 GEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRL 146
            |.|..||.::.....::|.|..    :.|..::.: ::.:|...|....||||.|||||::|||.
Yeast    80 GRFNGHVFYRVLQHSIVSTKFN----SRIDSEEAE-YIKLLELHLKNSTFYFSYTYDLTNSLQRN 139

Human   147 SNTSPEFQEMSLLERADQRFVWNGHL---LRELSAQ-PEVHRFALPVLHGFITMHSCSINGKYFD 207
            ....|    .:..:.||:||.||.:|   ||..:.| |.:..|..||::|:.......:|.....
Yeast   140 EKVGP----AASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIV 200

Human   208 WILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKA------SFVQTRGSIPVFWSQ 266
            ..||:|||.||||.||:.||:|.:|:..||.|||||:.....::      ||:|||||:|::|::
Yeast   201 LGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAE 265

Human   267 RPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSG 331
            ..||||||...:.:  |.:|..::|||.|..:||...::||:||||.|.|:::.:.::|.:|...
Yeast   266 INNLKYKPNLVLGE--NSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDP 328

Human   332 MMRYIAFDFHKECKNMRWDRLSILLDQVAEM---QDELSYFLVDSAG---QVVANQEGVFRSNCM 390
            .:.|:.||||.||:.|:|.|:.:|:|.:.::   .::..:.::||.|   ::|..|..|.|:|||
Yeast   329 KIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCM 393

Human   391 DCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGAL 455
            ||||||||:||:||:..||.:.:...|:..|...|:.......|:|.|||||:|.:..|:|||||
Yeast   394 DCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGAL 458

Human   456 KTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWK 520
            |||||||||||.||...|..||..|||:||::||.||||.|||||.:........||....|...
Yeast   459 KTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVY 523

Human   521 FLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWG---VASIGTFFIILYNGKDFVDAPRLV 581
            ...:|:|:..|.::....:....|.:|.:...:.|.|   |.::.|.| :..||..||:.|:||
Yeast   524 IQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKF-MFKNGIQFVNWPKLV 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SACM1L	NP_001306000.1	COG5329	57..513	CDD:227637	185/471 (39%)
SAC1	NP_012710.1	COG5329	3..578	CDD:227637	206/574 (36%)