Protein Alignment DHX30 and spn-E

DIOPT Version :10

• Sequence 1: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Sequence 2: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Alignment Length: 943
• Identity: 257/943 - (27%)
• Similarity: 407/943 - (43%)
• Gaps: 214/943 - (22%)

Human   440 SSWIAPELRLQSDDIL---PLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQE 501
            |..:|.|..|.:..:|   |.||....|.|..|..      |.||..:        ||....:::
  Fly    54 SKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDD------EGEETEI--------RRDDEYYKK 104

Human   502 -------APQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVII 559
                   ...|.:...|:.||.||..||||:|.|:|||||||::||.:|:.....|:  .||:::
  Fly   105 FRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVV 167

Human   560 TQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGV 624
            ||||||:|:|:|.||..|..........|||.|..........||:||.|:||..|.:|.:|...
  Fly   168 TQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHY 232

Human   625 SHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSATGDNERFSRYFGGCPVIKVPGFMYP 688
            :|:::|||||||.|.|||||:::.|...|.. ::::|||||.|.:..|.||  .....:|    |
  Fly   233 THIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYF--TTTNSIP----P 291

Human   689 V------KEHYLEDILA-KLGK---------HQY---LHRHRHHES----------EDECALDLD 724
            |      ::|.:|.... :||.         ||.   :::|.:..:          |.:.|:...
  Fly   292 VITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSR 356

Human   725 LVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHES-KYLILPVHSNIPMMDQKAIF 788
            ...|..|..      |.:|.||||..||..:.:.|...|....: |..|:...|.:...:|:.:|
  Fly   357 QSYDEALRY------GAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVF 415

Human   789 QQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGR 853
            ..||.|.|||:|.|||||:|||:.|:.:|:|..|.|.:..|..:..|.|...|.|:||..||.||
  Fly   416 NPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGR 480

Human   854 AGRCQSGFAYHLFPRSRLEKMVP-FQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIK 917
            .||.:||..|.:..:...::.:| |.:||:||.||:|.||:||: :...:.||.|:.|:..||:.
  Fly   481 VGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKV-LNMGSPVEILALALSPPNLS 544

Human   918 AVDEAVILLQEIGVLDQREYLTT-------------LGQRLAHISTDPRLAKAIVLAAIFRCLHP 969
            .:...::||:|:|.|    |||.             .|..::.:..|.|.::.|:|..||..|..
  Fly   545 DIHNTILLLKEVGAL----YLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEE 605

Human   970 LLVVVSCLTRDPFSSSLQNRAEVDK---VKALLSHDSGSDHLAFVRAVAGW----------EEVL 1021
            .:::.:.|:.....:....|:::..   :..:.|..||||.:|..|....:          |..:
  Fly   606 AIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAI 670

Human  1022 RWQDR---SSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEE 1083
            ||..|   |.|            ||:.||.|:::.........|:..|       ...|:..::.
  Fly   671 RWAKRFHVSLR------------SLKEIHLLVQELRVRCTHLGLIPFP-------VNPNQMMDDR 716

Human  1084 ELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT-------------YRTKSGNILLHKSTINR 1135
            |  |.:::             ||...|.|.||..|             |:|.||:
  Fly   717 E--KAIML-------------KVIIAGAFYPNYFTRSKESCADTDRNIYQTISGH---------- 756

Human  1136 EATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLE 1200
              ...|:.:.|.|..... |.::.|...::.....:...:.||..::..::..::....|.  :|
  Fly   757 --DPCRTVYFTNFKPAYM-GELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDW--IE 816

Human  1201 GDSRTV----RLLKEL----------------------------RRALGRMVE-------RSLRS 1226
            |.|:.|    |:..|:                            :|.:|.::|       :.|..
  Fly   817 GSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRGIGDVIEGRWIPPTKPLNV 881

Human  1227 ELAALPPSVQEE--HGQLLALLAELLRGPCGSF 1257
            ||.|| |||.::  .|.:..::      .||.|
  Fly   882 ELLAL-PSVFDKTISGSITCIV------NCGKF 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	190/599 (32%)
		OB_NTP_bind	1086..1173	CDD:400182	17/99 (17%)
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	196/613 (32%)
		DEXHc_TDRD9	115..295	CDD:350746	79/187 (42%)
		TUDOR	892..1016	CDD:425754	4/22 (18%)