Protein Alignment DHX30 and CG8915

DIOPT Version :10

• Sequence 1: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Sequence 2: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Alignment Length: 906
• Identity: 263/906 - (29%)
• Similarity: 443/906 - (48%)
• Gaps: 131/906 - (14%)

Human   365 GRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRK- 428
            |::|......|.|.|..||||      .:|.:         ||:|.:...:.|..:...|.|.|
  Fly    43 GKQKTRPGKNAKADAGDKLKS------EDEKM---------LRQLVDDFLQSCEPEKQLPGLTKA 92

Human   429 ----IETFLNHYPVESSWIAPE-------LRLQSD------------DILP-----LGKDSGPLS 465
                :.....|..:::....||       .|.|||            ||.|     ||:.:|.:.
  Fly    93 QRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVE 157

Human   466 DPI---TGKPYVPLLEAEEVRLSQSLLELWRRRGP---------VWQEAPQLPVDPHRDTILNAI 518
            ..:   .|.......:.:::||..:...:.:|..|         :..|...||:...|::|||.:
  Fly   158 RRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVL 222

Human   519 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 583
            ::..|::|.|.||.||:|::||.:|| :..|.| |...::::|||||:|:||::|:|.|.|.:..
  Fly   223 QRDQVLIIKGATGSGKSTQLPQYILE-WAAEHR-APVRIVVSQPRRIAAISVSERISKERGEAPG 285

Human   584 RNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPS--LEGVSHVIVDEVHERDVNTDFLLILL 646
            ..||:.:|: ::..|....|:..|.|.|||.|..:..  .:..:|:|:||.||||::|||||:..
  Fly   286 TTVGYNIRM-NRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLAT 349

Human   647 KGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLG-----KHQY 706
            |...:.||.|||||||||.|.|..|.||||..|:.|.|..:.|..::|||||:|.|     ..::
  Fly   350 KLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKF 414

Human   707 LHRHRHHESEDECA-------------LDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQR 758
            |.:....|:..|..             :|.||:..|:..:..:|:.|.::.:|||:.::..:..|
  Fly   415 LGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLAR 479

Human   759 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVR-KIVLATNIAETSITINDIVHVVDSGL 822
            |:.:|...:...::|  ||.:...:|:.:|:..| ||| ||:|:|||.:|||||.|:::|:|:||
  Fly   480 LESSLPREQITIILL--HSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGL 541

Human   823 HKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPL 887
            .|.:.||.....|.|...|:|:|:..||.|||||...|..|.|:...|:.:|..:.:|||:|..|
  Fly   542 AKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTL 606

Human   888 ENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDP 952
            :.:.|..|:..|:|....||:.|:|:|...||.::...|:.:||||:|:.:|.||..:|.:....
  Fly   607 DEICLLTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGV 671

Human   953 RLAKAIVLAAIFRCLHPLLVVVSC-LTRDPFSSSLQ----NRAEVDKVKALLSHDSGSDHLAFVR 1012
            ::.|.:|.:...|||..::::.:. ..||||..:::    :..::.:|  |.:.|..||.||.::
  Fly   672 QIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRV--LFAGDGMSDSLAVIK 734

Human  1013 AVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCN 1077
            .   :||....: |....::.|.|.:...::...........:.:|..|...:.| ..|||:
  Fly   735 L---YEEFTNLK-RKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEAS-ARLASS--- 791

Human  1078 EYSEEEELVKGVLMAGLYPN------------------LIQVRQGKVTRQGKFKPNSVTYRTKSG 1124
             ::.:..:::..|.|||||.                  |:||.:....| ||.|...:.    |.
  Fly   792 -FNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLR-GKKKQKDLA----SE 850

Human  1125 NILLHKSTINREATRLRS----RWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIR 1181
            .||..:.|  |.|.::.|    ..::..|...:.|..|:   ::.|...:||..|..:.::
  Fly   851 WILFVEKT--RTADQISSLEHTTLVSGLMVALAGGKRFI---TEAHGSEMLLCLDSWIRLK 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	194/566 (34%)
		OB_NTP_bind	1086..1173	CDD:400182	25/108 (23%)
CG8915	NP_573208.1	R3H	67..123	CDD:460206	10/64 (16%)
		HrpA	208..>702	CDD:441249	180/499 (36%)
		OB_NTP_bind	799..884	CDD:400182	21/91 (23%)