Protein Alignment EPN2 and lqf

DIOPT Version :10

• Sequence 1: NP_055779.2
• Gene: EPN2 / 22905
• HGNCID: 18639
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_729266.2
• Gene: lqf / 38846
• FlyBaseID: FBgn0028582
• Length: 831
• Species: Drosophila melanogaster
• Alignment Length: 793
• Identity: 286/793 - (36%)
• Similarity: 374/793 - (47%)
• Gaps: 254/793 - (32%)

Human     1 MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLN 65
            :..:.:||.:||:.:|||:|::||||||||||||||:::|:|||:||||||||||||.|:|||||
  Fly    10 VNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLN 74

Human    66 DHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQL 130
            |||||||||||||.||:||||||||:|||||:|||||||||::|.|.: :|||||.:||||:|||
  Fly    75 DHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFE-EGKDQGTHVREKAKQL 138

Human   131 VALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPAS 195
            |.||||:||||.||.:|.|.|||.||..:|.||:  .:..|.||.:|
  Fly   139 VTLLKDDERLKNERVKAQKAKERFAQNPSGFGSD--GYIDGPSQRDL------------------ 183

Human   196 YHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPR 260
                             |.|..||                                      .|:
  Fly   184 -----------------PPGWQEE--------------------------------------PPK 193

Human   261 VSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRD-------TVK 318
            ..||||..||||:||||||||||:|||||.|||||..||.||:|||:||.:|.:|       .:.
  Fly   194 SVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIP 258

Human   319 IPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPS--ASTNQTNPWG--GPAAPASTSDPW 379
            .|||:|     ||:.||||:|.  |.|..:..:.|.|.:  |.|...:||.  ||.||:..||||
  Fly   259 APKKEE-----QQSHLLDLLDI--SLGATSISSPPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPW 316

Human   380 PSFGTKPAASIDPW------------GVPT------------GATVQS----------------- 403
            .  ||. :..:|||            |||.            ||..||
  Fly   317 S--GTS-SPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNG 378

Human   404 -------------------------------VPKN---------SDPWAASQQPASSAGKRA--- 425
                                           .|.|         ||||.|  :||:||...|
  Fly   379 NANQNGRGATPAGPPAEGWLIKSTAVGALGAAPINHAANNGSSSSDPWLA--EPAASAAGGAAAV 441

Human   426 --SDAW--GAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFD--NLRTSKKTAESVTSLPSQNNGT 484
              :|.|  ||.|.|...::...::...  .|.||....|||  :|.|::..:|...|..|.||..
  Fly   442 GLADPWAPGAASQTGAGALDDPWKALG--TGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNA 504

Human   485 T---SPDPFES-----------QPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQ- 534
            :   ..||..:           .|.|.|::|.|.  |...||||.|:||||||:|:...||..|
  Fly   505 SLLDDMDPLSANYGNGGINSSMHPSTGATAKKSI--KDAHSFLGENSALVNLDNLIKPIAPQTQT 567

Human   535 ----SLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLR-------------GSPVLG-------- 574
                :.|||.....|..:   |.||..||...::|||:             .:||:|
  Fly   568 GNQPAYNPFSDNVVPPKT---NLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVSTTSQP 629

Human   575 --------TSTSFGPGPGVESMAVASMTS--------AAPQPALGATGSSLTPLGPAMMNMVGSV 623
                    ||.:.||....|...::::::        ..|||.|....::..  ..:..|::|..
  Fly   630 KLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQ--SSSSTNILGKS 692

Human   624 GIPPSAAQATGTT 636
            .||.:...:|..:
  Fly   693 NIPTNMNSSTSNS 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPN2	NP_055779.2	ENTH_Epsin	19..141	CDD:340787	95/121 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..214		5/50 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..275		9/19 (47%)
		Herpes_BLLF1	<320..550	CDD:282904	97/342 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..425		39/169 (23%)
		6 X 3 AA repeats of [DE]-P-W	352..639		109/435 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..512		13/55 (24%)
		3 X 3 AA repeats of N-P-F	537..639		29/137 (21%)
lqf	NP_729266.2	ENTH_Epsin	28..150	CDD:340787	96/122 (79%)
		UIM	208..227	CDD:197845	16/18 (89%)
		PHA03247	<278..394	CDD:223021	27/118 (23%)