DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CARD8 and atln-1

DIOPT Version :9

Sequence 1:	NP_001171829.1	Gene:	CARD8 / 22900	HGNCID:	17057	Length:	537	Species:	Homo sapiens
Sequence 2:	NP_001023492.1	Gene:	atln-1 / 177059	WormBaseID:	WBGene00021868	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	286	Identity:	53/286 - (18%)
Similarity:	89/286 - (31%)	Gaps:	116/286 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   326 HPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQT--------SPPMEP--------------- 367
            |.||:     |:|.:....:.::..||..|...|.|        .|.:..
Worm    20 HVEDV-----LLPKEPQAVRVVEVVEDTDHSFELNTELLEKILLDPKVADKKVAVIGVAGAYRKG 79

Human   368 ----LNFGSSYIVSNSANLKVMPKELKL---SYRSPGE-IQHFSKFYAGQMKEPIQLEITEKRHG 424
                |||...|:...|...||| .|::|   .:.||.. :..|| :..|..::         .:|
Worm    80 KSFLLNFFLRYLTWRSKADKVM-GEVELDNSQWMSPNSPLSGFS-WRGGSERD---------TNG 133

Human   425 TLVWDTEVKPVDLQLVAASAPPPFSGAAFVKE-NHRQLQARMGDLKGVL---------------- 472
            .|:|.                .||    .:|: |..::...:.|.:|..
Worm   134 ILIWS----------------EPF----IMKDKNGEEIAVLLMDTQGAFDSQSTVKDCATIFALS 178

Human   473 -----------------DDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVE------------K 508
                             ||||..::.||..:..:|...::..  ::||.:|.            :
Worm   179 TMISSVQIYNLSQNIQEDDLQHLQLFTEYGRLALEDSASKPF--QSLLFLVRDWSFPYEAEFGFQ 241

Human   509 KGDLALDVLFRSISERDPYLVSYLRQ 534
            .|...||... .:||:....:..|||
Worm   242 GGQRVLDRRL-EVSEKQHAELQQLRQ 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CARD8	NP_001171829.1	ZU5. /evidence=ECO:0000303\|PubMed:22087307	161..296
		FIIND	182..436	CDD:316110	29/140 (21%)
		UPA. /evidence=ECO:0000303\|PubMed:22087307	297..446		29/150 (19%)
		CARD	453..535	CDD:306972	22/128 (17%)
atln-1	NP_001023492.1	P-loop_NTPase	43..325	CDD:393306	46/258 (18%)
atln-1	NP_001023492.1	GBP_C	351..>447	CDD:308475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910