DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGEF15 and Exn

DIOPT Version :9

Sequence 1:	XP_011522036.1	Gene:	ARHGEF15 / 22899	HGNCID:	15590	Length:	856	Species:	Homo sapiens
Sequence 2:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	241/939 - (25%)
Similarity:	357/939 - (38%)	Gaps:	224/939 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    38 HNGSSPQELPRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSAS--------RASLDSQTSP--- 91
            |....|....||.||:...|......:||          ||...        :..:.|:.||
  Fly  1167 HGDGEPDLRQRNYNDSGVDMRNHRLPKPP----------PPQNQVYEFVRKFKDFISSKKSPKGS 1221

Human    92 ------DSPSSTPTPSPVSRRSA--------SPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNG 142
                  ::|:||......|:|:.        .||     .:|.|:..|.......|:.....:||
  Fly  1222 QQKLYENTPASTLFYVECSKRTEDVYENTDFGPE-----RIPAPETKGPVHQEQAPVLRAKQKNG 1281

Human   143 SASAPGTVRRLAG------RFEGGAEGRA----QDADAPEPGLQARADVNGEREAPLTGSGSQEN 197
            .:......:.|.|      :....|..|:    :|.:...|.|....:::|             :
  Fly  1282 KSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHG-------------S 1333

Human   198 GAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSRS------------- 249
            |..|:|.:...|.|                      :|..|:.::..|.::.
  Fly  1334 GELDSGFSDKNCTP----------------------LPETPKFSTVARKAKKEAKANRRRTTIGL 1376

Human   250 RPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIF-----------GDPP------ 297
            ||:.|....|.:.........||:    |...:.|....:..:|           ||.|
  Fly  1377 RPNDPPPPPPPMTGNKSPLDPERE----LDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPS 1437

Human   298 --------QPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGL-EVLKEQNWELPLQDEPLY 353
                    ..:..|....||....|...:..:|       ..|.|| :.|..:...| ..:||||
  Fly  1438 GHGGVSSWYAESGLYQTSGISVASSSGSSGVST-------GNEAGLGDELSSEPHSL-FSNEPLY 1494

Human   354 QTYRAAVLS---------------EELWGVGEDGSPSPANAGDAPTFPRPP---------GPRNT 394
            |.|.||.|.               ||: |:.....|.|.      ..|||.         ||..|
  Fly  1495 QMYSAAKLESITRDLEAHGSSDGYEEI-GLQAKAKPEPL------VKPRPTALQLVEPKNGPSRT 1552

Human   395 LWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDT--LTPRD 457
            ||.|:|.|..|.:|.||:.:||.:||:.||::|||||||:||.||...|:...|..|:  |:.:|
  Fly  1553 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKD 1617

Human   458 HHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYS 522
            ...|||.:..|...|||.|..|.:..:.:..:..|...::..|...|.|||.:..:|...:.|..
  Fly  1618 RKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLR 1682

Human   523 RLMDT--NVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQGHRAGGPVTLPPCPQNI 585
            ||.::  ::.|...|.||::.|.|..|.|.|||:||.||||||.:|:..      |.....|.|
  Fly  1683 RLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDA------VFSKESPLN- 1740

Human   586 LRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF-HKVKALPLV----- 644
               .||    .|:.:..|..|.|::.:|:....|.:|..||.|:.::|.| ..|:||.:.
  Fly  1741 ---REE----YESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVP 1798

Human   645 ---SWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCL--LLFSDLLLITQPKSGQRLQVLDYAH 704
               :..|.|..:||||.|..|..........|.|.:.:  .|||||||:.:.:......|.||..
  Fly  1799 RAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCP 1863

Human   705 RSLV------QAQQVP-----DPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAF---- 754
            ||::      ...|:|     |.:|.....::||.|...:....:|...|:||.||||.|.
  Fly  1864 RSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPE 1928

Human   755 -PTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLK------GL 812
             .|||      :.:||..||.|.:...|....:.:...||.........|.|:||.:      |.
  Fly  1929 AETPG------EKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGA 1987

Human   813 PGAFPAQLVCEVTGEHERRRHLRQNQRLL 841
            .|.||.....|:...|.|.|:|:|..|||
  Fly  1988 VGWFPGSYTEELNSAHVRARNLKQRHRLL 2016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF15	XP_011522036.1	RhoGEF	422..613	CDD:279015	66/194 (34%)
ARHGEF15	XP_011522036.1	PH_ephexin	637..757	CDD:269929	41/145 (28%)
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	67/195 (34%)
		PH_ephexin	1805..1931	CDD:269929	38/125 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5908
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001805
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	1	1.000	-	-		X1705
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.940