DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP4 and Fkbp14

DIOPT Version :9

Sequence 1:	NP_002005.1	Gene:	FKBP4 / 2288	HGNCID:	3720	Length:	459	Species:	Homo sapiens
Sequence 2:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	200	Identity:	65/200 - (32%)
Similarity:	92/200 - (46%)	Gaps:	29/200 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    50 GDRVFVHYTGWL-LDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAY 113
            ||.:.:||||.| .||.|||||.||...|:|.||.|:|||.||..:..|.|||...:|..|:..|
  Fly    44 GDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGY 108

Human   114 GSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYY 178
            |..|:...|||.|||:|:|||........|.    .:.:.|....:......|   |.|.:..|.
  Fly   109 GDQGAGNVIPPKATLLFDVELINIGNAPPTT----NVFKEIDDNADKQLSREE---VIVYVSEYL 166

Human   179 KDKLF-----DQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIP 238
            |.::.     |..||:..:.|.:.|     :|...|..:|.::           |.:..::|..|
  Fly   167 KKQMTAVEGQDSEELKNMLAENDKL-----VEEIFQHEDKDKN-----------GFISHDEFSGP 215

Human   239 PNAEL 243
            .:.||
  Fly   216 KHDEL 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP4	NP_002005.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..134	CDD:306713	43/84 (51%)
		FKBP_N	<155..254	CDD:332399	17/93 (18%)
		TPR_11	<250..>395	CDD:330823
		Interaction with tubulin. /evidence=ECO:0000250	267..400
		TPR repeat	274..301	CDD:276809
		TPR repeat	306..348	CDD:276809
		TPR repeat	353..381	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..459
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	44/85 (52%)
		EF-hand_7	140..212	CDD:290234	15/90 (17%)
		EFh	141..212	CDD:298682	15/89 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810