DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP4 and CG1847

DIOPT Version :9

Sequence 1:	NP_002005.1	Gene:	FKBP4 / 2288	HGNCID:	3720	Length:	459	Species:	Homo sapiens
Sequence 2:	NP_001368980.1	Gene:	CG1847 / 32144	FlyBaseID:	FBgn0030345	Length:	390	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	98/391 - (25%)
Similarity:	138/391 - (35%)	Gaps:	122/391 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    50 GDRVFVHY-TGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHIT-----CK 108
            |.||..|: |....|....|.|...:......|||...::.|::.:..|.:.||...|     |
  Fly    29 GTRVKFHFQTRRAGDSRIIDDSRKMEKPMELVLGKKFKLEVWELIVQQMSLNEVAKFTVHKSLC- 92

Human   109 PEYAYGS-----AGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGA 168
            .:|.:.|     .|..|                       ||........:|..|.||.
  Fly    93 AQYPFISKTLRDIGKKP-----------------------EERRHCCGMTLQNEGIGYT------ 128

Human   169 IVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKE 233
                           |..||         |..|..||..|                        |
  Fly   129 ---------------DLDEL---------LQNPSDLEFII------------------------E 145

Human   234 KFQIPPNAEL--KYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKK- 295
            .|.|    ||  :||         ||.|:|:.:||:..::.::|||..::|..::.:|...|::
  Fly   146 LFSI----ELPEQYE---------KERWQMSDDEKMLATSTLRERGNNFYKASRFTEAETCYREA 197

Human   296 --IVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFR 358
              ||..|..:....:||.|:..|::....||.|.|.|....|.|.||.||:.|.||..|.|.|||
  Fly   198 VGIVEQLMLKEKPHDEEWQELAAIKTPLLLNYAQCRLIAGDFYAVIEHCNEVLTLDPRNVKALFR 262

Human   359 RGEAHLAVNDFELARADFQKVLQLYPNNKAA----------KTQLAVCQQRIRRQLAREKKLYAN 413
            |.:||....:...||.||...|.|..:.|:.          :.|....|.||..|     ||: |
  Fly   263 RAKAHAGAWNPAQARRDFLDALALDASLKSTVSKELKSIEDQQQARNVQDRIHMQ-----KLFXN 322

Human   414 M 414
            :
  Fly   323 I 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP4	NP_002005.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..134	CDD:306713	21/94 (22%)
		FKBP_N	<155..254	CDD:332399	19/100 (19%)
		TPR_11	<250..>395	CDD:330823	49/157 (31%)
		Interaction with tubulin. /evidence=ECO:0000250	267..400		44/145 (30%)
		TPR repeat	274..301	CDD:276809	8/29 (28%)
		TPR repeat	306..348	CDD:276809	16/41 (39%)
		TPR repeat	353..381	CDD:276809	11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..459
CG1847	NP_001368980.1	FKBP_C	23..>92	CDD:395196	16/62 (26%)
		3a0801s09	150..>308	CDD:273380	53/166 (32%)
		TPR repeat	173..217	CDD:276809	11/43 (26%)
		TPR repeat	222..252	CDD:276809	12/29 (41%)
		TPR repeat	257..285	CDD:276809	11/27 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910