Protein Alignment INPP5F and INP52

DIOPT Version :10

• Sequence 1: NP_001427929.1
• Gene: INPP5F / 22876
• HGNCID: 17054
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_014293.1
• Gene: INP52 / 855618
• SGDID: S000005050
• Length: 1183
• Species: Saccharomyces cerevisiae
• Alignment Length: 1141
• Identity: 260/1141 - (22%)
• Similarity: 430/1141 - (37%)
• Gaps: 283/1141 - (24%)

Human    48 VEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELE------L 106
            :.|.||.|::...:  ::..|..|:.|.:...:..|.|:..:....|:..:...::::      :
Yeast    60 IYGFIGLIEIEGLM--FIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIV 122

Human   107 CKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFM 171
            .....|.|:.|..|             .||  |:.|:......:....:|:..:....||.|: :
Yeast   123 TNDGDFAISSPPSI-------------STH--SSRSSLRSSSSRSLNAQEQAPKHPCHELRKL-L 171

Human   172 DSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQ---------DLTEIGTPDV 227
            .:.|||||..:|||.::|::  |..:....:...|..|.||.:::.         |:|.....|.
Yeast   172 SNGSFYYSTDFDLTCTLQKR--GFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQ 234

Human   228 DFWIIPMIQGFVQ-----IEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRH 287
            ..::..:|:||.:     |..|.|..|                              :|||:|..
Yeast   235 RGFLTTVIRGFAETIFSYINRLKVGLT------------------------------IISRQSWK 269

Human   288 RAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEK 352
            |||.|:..||:|.:|:|||:||||.:::...:..:|.|.|||:|:||.|.....:|:.::.||.:
Yeast   270 RAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVE 334

Human   353 ETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSH-------LTYVSFDF 410
            .|...|..||......|....||||:.....|..:...|.:|:   .||.       :...||||
Yeast   335 ATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQL---KNSEKMKIGRDVFLTSFDF 396

Human   411 HEHCRGMKFENVQTLTDAIYDIILDMKWCWVD--EAGVICKQEGIFRVNCMDCLDRTNVVQAAIA 473
            |.......|.....:...|.:.|||..:...|  |..:|.:|:|:||.||:|||||||::|..|:
Yeast   397 HRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTIS 461

Human   474 RVVMEQQLKKLGVMPPEQPLPVKCNRIYQ---IMWANNGDSISRQYAGTAALKGDFTRTGERKLA 535
            ..|.:..|:...::.|..  .:..|...|   .:||:|||.||:.|.||.|||..::|.|:...:
Yeast   462 LAVFKLFLEDFRLVKPSS--FIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFS 524

Human   536 GVMKDGVNSANRYYLNRFKDAYRQAVIDINNSTLDLMQGI----PVTEDLYSIFTKEKEHEALHK 596
            |.:.|...|.:|.|:|.|.|..:|..||.....|...|.:    |:.|.:.....:.:|....|.
Yeast   525 GALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHS 589

Human   597 E----------NQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLL- 650
            .          |..|.:..:|       |.|.|..:||         .|.::....::|..|..
Yeast   590 NINLFVGTFNVNGNSRRADLS-------KWLFPIGDKF---------KPDVVVLGLQEVIELTAG 638

Human   651 -LSNSAYYVAYYDDEV--DKVNQYQR----LSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEA 708
             :.|:.|..:.:.:.:  |.:|||:.    |.:|.:..:.|     ||    |:.....|..||.
Yeast   639 SILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLI-----LF----FARSDRAYNIKEV 694

Human   709 SGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQN 773
            .|                           ...|...|                      || :.|
Yeast   695 GG---------------------------STKKTGFG----------------------GI-TGN 709

Human   774 QGSLAQGKNFLMSKFSSLNQKVKQTKSNV-----NIGNLRKLGNFTKPEMKVNFLKPNLKVNLWK 833
            :|::|...::..:.|..:|..:....||:     :..|:.:  |.|.|..|.   .|:.....|.
Yeast   710 KGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYR--NITFPRSKT---IPHHDSLFWL 769

Human   834 SDSSLE-TMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLP 897
            .|.:.. |:.|..|..:::|:.||         :.|..|   :.|:..|..|.
Yeast   770 GDLNYRITLTNDEVRRELRAQKDG---------YIDRLL---QYDQLTQEINE------------ 810

Human   898 SCGIIASA---PRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGD------- 952
              |::...   |.|..|.                |..:..|......|...::||..|
Yeast   811 --GVVFQGFKEPTLQFRP----------------TYKYDYGTDNYDTSEKARTPSWTDRIIYKGE 857

Human   953 -VHILTGFAKPMDIYCH-----------RFVQD-----------AQNKVTHLSETRSVSQQASQE 994
             :|.|.....|:.|..|           :||.:           |:.|.||.....:...:.|..
Yeast   858 NLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHA 922

Human   995 RNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETG 1059
            |  |..|..:.....:.:....:...||.:.|...|......|..||..   |...|::...::.
Yeast   923 R--MEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVG---PGGLSNVSPDKSK 982

Human  1060 LHVTPSPSESS------SSRAVSPFAKIRSSMVQVA 1089
            |:|.|.|..:|      ||:.:||..:|  |:|.|:
Yeast   983 LNVLPPPPPTSRHNKEPSSKLLSPTKEI--SIVSVS 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5F	NP_001427929.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..882		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..949		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1024		6/42 (14%)
INP52	NP_014293.1	COG5329	1..628	CDD:227637	165/638 (26%)
		COG5411	564..1052	CDD:227698	108/582 (19%)
		Aim21	<978..1166	CDD:371558	13/41 (32%)