Protein Alignment INPP5F and sac-2

DIOPT Version :10

• Sequence 1: NP_001427929.1
• Gene: INPP5F / 22876
• HGNCID: 17054
• Length: 1139
• Species: Homo sapiens
• Sequence 2: NP_001252206.1
• Gene: sac-2 / 173236
• WormBaseID: WBGene00012353
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 863
• Identity: 275/863 - (31%)
• Similarity: 435/863 - (50%)
• Gaps: 155/863 - (17%)

Human    13 QQGERALWCSRRDGGLQLRPATDL-LLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGK 76
            :||||..: .||:|.:..:|...| :|..:.:..|.||.:||||..  |...:|..:...::|..
 Worm    14 EQGERVEF-DRRNGKVLEKPEESLEILDQDVVLCGNVEFLIGKISF--DEQHFLFFVVDSSVVAC 75

Human    77 LPG-----DHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTH 136
            ..|     .|.:.::.::..:::..                            |.|.
 Worm    76 YRGTSAESSHSIRRIERVIAINVKS----------------------------DGSV-------- 104

Human   137 IKSNVSAPNKKKVKESKEK------EKLER-----RLLEELLKMFMDSESFYYSLTYDLTNSVQR 190
            |||.::..:..|:|:..||      ||:.:     .||:::||:|.||:.||:..:.|:|.|.|:
 Worm   105 IKSQITPGSGTKLKQGTEKIMKFFAEKVTKAEPRPALLDDVLKLFNDSKDFYFCRSRDVTISSQK 169

Human   191 QSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDE 255
            ... :|:.    ...:|.|||||.|:.:|.|....|.  :..|::||:|...:|.:
 Worm   170 YFE-KREA----HTSEDSFFWNKRMVGNLGEAKISDK--FTCPIMQGYVATSQLEI--------- 218

Human   256 KSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHT 320
                         .|.|:....:.:|||||..|||.||.|||:|:..||||:||||.::::..|.
 Worm   219 -------------TDQINAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHE 270

Human   321 LSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVI-INLVDQAGRE 384
            |||||.|||:||||||.|::|.|...::||.:||...|..||:.....|...:: ::||||.|||
 Worm   271 LSFVQCRGSIPVFWSQRGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYDTPLVAVSLVDQRGRE 335

Human   385 KIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAG-VIC 448
            ..:...:|:..:..:::.:|:.|||.|:||||:.|:.:|||..::.:.:..:.:||||:.| |:.
 Worm   336 LPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQ 400

Human   449 KQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSIS 513
            .|:|:.|.||:|||||||:||..|:..|:.||.::||:..|....|....:..|.|||:|||.||
 Worm   401 SQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFGPLCEPPEVLVQTMQTMWADNGDVIS 465

Human   514 RQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDINNSTLDLMQGIPVT 578
            .|||||||||||.||.|||||.||||||.|||:||||...|||.||..|:|            ||
 Worm   466 TQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINI------------VT 518

Human   579 EDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHR 643
            ..      .|.:..|..:||::..:|.||:::...::.|:|..:....||.||:...|     ..
 Worm   519 GQ------TEADENAEEEENEKEEEENISRMVTETIQFLVPTQQTVIAGWGLINAFQS-----SD 572

Human   644 DVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEA 708
            ::|.:::|:.|..|:..|:.:.:|:...|.::||::..|:.|..    |..: .|.||    :..
 Worm   573 EIDTVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGTS----GNNR-QCARL----ETL 628

Human   709 SGYF----HTLR-----AVMRNPEEDGKDTLQCIAEMLQITKQ----AMGSDLPII-----EKKL 755
            .|.|    .|:|     |:.....|:..:.:..:||.:|:.:.    |.||.:|:.     :..:
 Worm   629 EGVFIWRPSTVRLFNNTAIRLKSLEEANEYISSVAEQIQVGRNMLTGAEGSVVPVAKITIPQMSV 693

Human   756 ERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKL-GNFTKPEMK 819
            .|||...           .|:|. ||...:.|.|||:    ::.|.::...|.:. ||.:....|
 Worm   694 HRKSMAA-----------MGALF-GKIKRVGKPSSLS----KSASTISTAQLPETDGNESDASQK 742

Human   820 VNFLKPN-LKVNLWKSDS 836
            .:.|... ||::.:||||
 Worm   743 SDHLMTKILKMSQFKSDS 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5F	NP_001427929.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..882
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..949
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1024
sac-2	NP_001252206.1	COG5329	25..520	CDD:227637	204/573 (36%)
		hSac2	549..>615	CDD:463592	17/70 (24%)