Protein Alignment SEC31A and Sec31a

DIOPT Version :10

• Sequence 1: NP_001387083.1
• Gene: SEC31A / 22872
• HGNCID: 17052
• Length: 1251
• Species: Homo sapiens
• Sequence 2: XP_006250739.1
• Gene: Sec31a / 93646
• RGDID: 620233
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1265
• Identity: 1130/1265 - (89%)
• Similarity: 1183/1265 - (93%)
• Gaps: 17/1265 - (1%)

Human     1 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65

Human    66 SHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDV 130
            |||||||||||:||||||||||||||||||||||||||||||||||||||||.||||||||||||
  Rat    66 SHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRALDV 130

Human   131 NIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 NIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATV 195

Human   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHA 260
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
  Rat   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVVQMWDLRFASSPLRVLENHA 260

Human   261 RGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 RGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Human   326 GRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWI 390
            |||.||||||||.||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   326 GRIRVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTSQHSIVLPLKKPPKWI 390

Human   391 RRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFI 455
            ||||||||||||||||||||.....|||||.::| .||||||||||:|||||:|||..|||||||
  Rat   391 RRPVGASFSFGGKLVTFENVTGQPQQGAEQPRRQ-PVFISQVVTEKDFLSRSEQLQHVVQSQGFI 454

Human   456 NYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDGANVALKD 520
            :|||||||||||:||||||||||||||:|||||||||||||:||||:|||||||:|||::|||||
  Rat   455 SYCQKKIDASQTDFEKNVWSFLKVNFEEDSRGKYLELLGYRREDLGEKIALALNRVDGSDVALKD 519

Human   521 SDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSS-GGTFNISVSGDIDGLITQALLTGNFES 584
            ||:|||||||||||.|.|||||.|||||:|.:||||: |||||||||||||||||:|||||||||
  Rat   520 SDRVAQSDGEESPAEEGQLLGERIKEEKQECDFLPSAGGGTFNISVSGDIDGLITRALLTGNFES 584

Human   585 AVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNW 649
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
  Rat   585 AVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNW 649

Human   650 REALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHP 714
            ||||||||||||||||||||||||.|||:||||||:||||||||||||||:||||||||||||:|
  Rat   650 REALAAVLTYAKPDEFSALCDLLGARLESEGDSLLRTQACLCYICAGNVERLVACWTKAQDGSNP 714

Human   715 LSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNI 779
            ||||||||||||||||||||||:||:|||.|||.|||||||||||||||||||||||||||||:|
  Rat   715 LSLQDLIEKVVILRKAVQLTQALDTNTVGALLAEKMSQYANLLAAQGSIAAALAFLPDNTNQPDI 779

Human   780 MQLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHVRIAPTVTTW 844
            :|||||||||||..|.|.||.:..||.|.||||.|||:|||.|:.|||:|||||.||||||||||
  Rat   780 VQLRDRLCRAQGRSVPGQESSRSSYEGQPLPKGGPGPLAGHPQVSRVQSQQYYPQVRIAPTVTTW 844

Human   845 SNKTPTALPSHPPAASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQ 909
            |::||||||||||||.||||||.|||||||||||||.||:...|||||||||:|.||||||||||
  Rat   845 SDRTPTALPSHPPAACPSDTQGGNPPPPGFIMHGNVVPNSPAPLPTSPGHMHSQPPPYPQPQPYQ 909

Human   910 PAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATSF 974
            |||.|.|||||||:||||||||||.||||||.||:|..:||:||.|:|.|| .|||||||.| ..
  Rat   910 PAQQYSFGTGGSAVYRPQQPVAPPASNAYPNAPYVSPVASYSGQPQMYTAQ-PASSPTSSSA-PL 972

Human   975 PPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRT-------------GPQNGW 1026
            |||||||||||||||||||||||||||||||||.||||||||||||             ||||||
  Rat   973 PPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTENQSFQDQSSVLEGPQNGW 1037

Human  1027 NDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGG 1091
            ||||||||||||||:|||||||||||||||||.||||.|.|||||||..|.||.:|||||||.||
  Rat  1038 NDPPALNRVPKKKKLPENFMPPVPITSPIMNPGGDPQPQGLQQQPSASGPRSSHASFPQPHLAGG 1102

Human  1092 QPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFED 1156
            |||||:||||.||||||||||||.|||||||||||.||||:|||:||||||||||||||||||||
  Rat  1103 QPFHGIQQPLAQTGMPPSFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPDEHLILKTTFED 1167

Human  1157 LIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHT 1221
            ||||||||||||||||||||||||||.||||||:|||||||.||||:|||||||||||||||:||
  Rat  1168 LIQRCLSSATDPQTKRKLDDASKRLECLYDKLRDQTLSPTIISGLHSIARSIETRNYSEGLTVHT 1232

Human  1222 HIVSTSNFSETSAFMPVLKVVLTQANKLGV 1251
            ||||||||||||||||||||||:||:||||
  Rat  1233 HIVSTSNFSETSAFMPVLKVVLSQASKLGV 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC31A	NP_001387083.1	WD40	13..332	CDD:475233	314/318 (99%)
		WD40 repeat	13..65	CDD:293791	51/51 (100%)
		WD40 repeat	70..119	CDD:293791	47/48 (98%)
		WD40 repeat	125..162	CDD:293791	36/36 (100%)
		WD40 repeat	172..208	CDD:293791	35/35 (100%)
		WD40 repeat	214..257	CDD:293791	41/42 (98%)
		WD40 repeat	263..302	CDD:293791	38/38 (100%)
		WD40 repeat	306..331	CDD:293791	23/24 (96%)
		ACE1-Sec16-like	<573..>696	CDD:449359	117/122 (96%)
		Atrophin-1	776..>1129	CDD:460830	288/365 (79%)
Sec31a	XP_006250739.1	WD40 repeat	13..65	CDD:293791	51/51 (100%)
		WD40 repeat	70..119	CDD:293791	47/48 (98%)
		WD40	84..340	CDD:475233	251/255 (98%)
		WD40 repeat	125..162	CDD:293791	36/36 (100%)
		WD40 repeat	172..208	CDD:293791	35/35 (100%)
		WD40 repeat	214..257	CDD:293791	41/42 (98%)
		WD40 repeat	263..302	CDD:293791	38/38 (100%)
		WD40 repeat	306..331	CDD:293791	23/24 (96%)
		ACE1-Sec16-like	<573..767	CDD:449359	182/193 (94%)
		PHA03247	<807..1159	CDD:223021	285/353 (81%)