DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SEC31A and SEC31

DIOPT Version :10

Sequence 1:NP_001387083.1 Gene:SEC31A / 22872 HGNCID:17052 Length:1251 Species:Homo sapiens
Sequence 2:NP_010086.2 Gene:SEC31 / 851332 SGDID:S000002354 Length:1273 Species:Saccharomyces cerevisiae


Alignment Length:1411 Identity:353/1411 - (25%)
Similarity:588/1411 - (41%) Gaps:321/1411 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     1 MKLKEVDRTAMQAWSPAQNH---PIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCAT 62
            :||.|..|||..|||    |   |: |.:||.:..:||.|||::|||::.|..:|..   |..|:
Yeast     2 VKLAEFSRTATFAWS----HDKIPL-LVSGTVSGTVDANFSTDSSLELWSLLAADSE---KPIAS 58

Human    63 FSSSHRYHKLIWGPYKMDSKGDVSGVLIAGG-ENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVR 126
            .....:::.|.|..         :..:|||. :||::.||..::  |.:....:|:...|:..|:
Yeast    59 LQVDSKFNDLDWSH---------NNKIIAGALDNGSLELYSTNE--ANNAINSMARFSNHSSSVK 112

Human   127 ALDVNIFQTNLVASGANESEIYIWDLN-------NFATPMTPGAKTQPPEDISCIAWNRQVQHIL 184
            .:..|..|.|::|||.|..||:|||:|       |: ||:|||......:::..:|||:.:.|:.
Yeast   113 TVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNY-TPLTPGQSMSSVDEVISLAWNQSLAHVF 176

Human   185 ASASPSGRATVWDLRKNEPIIKVS----DHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWD 245
            |||..|..|::|||:..:.:|.:|    :...:...|.:.|||..:|::..|:..|..|.|.:||
Yeast   177 ASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWD 241

Human   246 LRFASSPLRVL-ENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDI 309
            ||.|::||:.| :.|.:|||::.|...|..||||.|:|..:|..||.:.|.|.:.|....|||..
Yeast   242 LRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKT 306

Human   310 QWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQ-----KQVDKLSSSFGNLDPFGTGQPLPPLQ 369
            ::.|..|.:.:.||||.:|.|.::. ..|:.|.:     ||.:..:..:.|:.            
Yeast   307 KFAPEAPDLFACASFDNKIEVQTLQ-NLTNTLDEQETETKQQESETDFWNNVS------------ 358

Human   370 IPQQTAQHSIVLPLKKPPKWIRRP-VGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVV 433
             .:::.:...|..| :.|.|...| ..|.::||||||..    .|..:|..             :
Yeast   359 -REESKEKPTVFHL-QAPTWYGEPSPAAHWAFGGKLVQI----TPDGKGVS-------------I 404

Human   434 TEKEF--LSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYR 496
            |..:.  |..:..|.:|::::.|.....:::.....:..:..|:.|: ....|...::|      
Yeast   405 TNPKISGLESNTTLSEALKTKDFKPLINQRLVKVIDDVNEEDWNLLE-KLSMDGTEEFL------ 462

Human   497 KEDLGKKIALALNKVDGANVALKDSDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTF 561
                  |.|||.           |:|   :||.::....|::..||...:: .|:.|.|.  |.|
Yeast   463 ------KEALAF-----------DND---ESDAQDDANNEKEDDGEEFFQQ-IETNFQPE--GDF 504

Human   562 NISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKK-YFAK--SQS 623
              |:||:|:..|::.|::||.:|||...|.::.:.:|:::|:....|.|..:.|. ||||  |:|
Yeast   505 --SLSGNIEQTISKNLVSGNIKSAVKNSLENDLLMEAMVIALDSNNERLKESVKNAYFAKYGSKS 567

Human   624 KITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDL---LGTRLENEG---DS 682
            .::|::.::..:...::||:.|:..|: .::..:....|::.:...::   ||.||:..|   ||
Yeast   568 SLSRILYSISKREVDDLVENLDVSQWK-FISKAIQNLYPNDIAQRNEMLIKLGDRLKENGHRQDS 631

Human   683 LLQTQACLCYICAGNVEKLVACW--------------TKAQDGSHPLSLQDLIEKVVILRKAVQL 733
            |      ..|:.||:::|:.:.|              .|....:|...|.:.||:..:....:..
Yeast   632 L------TLYLAAGSLDKVASIWLSEFPDLEDKLKKDNKTIYEAHSECLTEFIERFTVFSNFING 690

Human   734 TQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFL----PDN----TNQPNIMQLRDRLCRAQ 790
            :..::...    |.||..::.||..:.|:...|..||    .||    |.:..::....:...||
Yeast   691 SSTINNEQ----LIAKFLEFINLTTSTGNFELATEFLNSLPSDNEEVKTEKARVLIASGKSLPAQ 751

Human   791 GEPVAGHESPKIPYEKQQ-----LP-KGRPG---------------PVAGHHQMPRVQTQQYYPH 834
            ....|.....|....|..     || .|.|.               |.|..:.:|   .:.|.|.
Yeast   752 NPATATTSKAKYTNAKTNKNVPVLPTPGMPSTTSIPSMQAPFYGMTPGASANALP---PKPYVPA 813

Human   835 VRIAPTVTTWSNKTPTALPSHPPAASP------SDTQ-GENPPPPGFIMHGNVNPNAAGQLPTSP 892
            ...:..|.|.....|   ||.|..|||      |.|: ....|||        ||.|...:|.  
Yeast   814 TTTSAPVHTEGKYAP---PSQPSMASPFVNKTNSSTRLNSFAPPP--------NPYATATVPA-- 865

Human   893 GHMHTQVPPYPQPQ----PYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQ 953
                |.|.....||    |.||..|........:...|.|   ||.:.....||:::..:: .|.
Yeast   866 ----TNVSTTSIPQNTFAPIQPGMPIMGDYNAQSSSIPSQ---PPINAVSGQTPHLNRKAN-DGW 922

Human   954 SQL---------------YAAQHQASSPT------SSPATSFPPPPSSGASFQHGGPGAPPSSSA 997
            :.|               .|..:..|:||      ::.|::.||||.|.|          |||.:
Yeast   923 NDLPLKVKEKPSRAKAVSVAPPNILSTPTPLNGIPANAASTMPPPPLSRA----------PSSVS 977

Human   998 YALPP-----GTTGTLPAASELPASQRTGPQNGWNDPPALNRVPKKKKMPENFMPPVPITS---- 1053
            ...||     ....:|.|.||.|.:..:.|.    .||     ...::.|...:.....||    
Yeast   978 MVSPPPLHKNSRVPSLVATSESPRASISNPY----APP-----QSSQQFPIGTISTANQTSNTAQ 1033

Human  1054 -PIMNPLGDPQSQMLQQQ-----PSAPVPLSSQSSFPQPHLPGG--QPFHGVQQPLG-------Q 1103
             ...||...|..|.:...     |.||:|.:|     .|:.|..  ||......|.|       .
Yeast  1034 VASSNPYAPPPQQRVATPLSGGVPPAPLPKAS-----NPYAPTATTQPNGSSYPPTGPYTNNHTM 1093

Human  1104 TGMPPSFSKPNIEGAPGAPI-----GNTFQHVQSLPTKKITKKP--------------------- 1142
            |..||.|:||. .|.|  ||     .|....::..|::..|..|                     
Yeast  1094 TSPPPVFNKPP-TGPP--PISMKKRSNKLASIEQNPSQGATYPPTLSSSASPLQPSQPPTLASQV 1155

Human  1143 ----------IP-DEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTL--S 1194
                      || |:..|:....|:|.:  ::..|..:..::|.|..|||:.|:..|.:|.|  .
Yeast  1156 NTSAENVSHEIPADQQPIVDFLKEELAR--VTPLTPKEYSKQLKDCDKRLKILFYHLEKQDLLTQ 1218

Human  1195 PTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLK 1240
            |||.. ||::...::.:.|.|.:.:|.:| :|::..|...::..:|
Yeast  1219 PTIDC-LHDLVALMKEKKYKEAMVIHANI-ATNHAQEGGNWLTGVK 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEC31ANP_001387083.1 WD40 13..332 CDD:475233 112/334 (34%)
WD40 repeat 13..65 CDD:293791 20/54 (37%)
WD40 repeat 70..119 CDD:293791 11/49 (22%)
WD40 repeat 125..162 CDD:293791 18/43 (42%)
WD40 repeat 172..208 CDD:293791 13/35 (37%)
WD40 repeat 214..257 CDD:293791 17/43 (40%)
WD40 repeat 263..302 CDD:293791 16/38 (42%)
WD40 repeat 306..331 CDD:293791 9/24 (38%)
ACE1-Sec16-like <573..>696 CDD:449359 34/131 (26%)
Atrophin-1 776..>1129 CDD:460830 101/434 (23%)
SEC31NP_010086.2 WD40 repeat 12..61 CDD:293791 20/56 (36%)
WD40 <14..327 CDD:441893 111/332 (33%)
WD40 repeat 66..106 CDD:293791 11/50 (22%)
WD40 repeat 111..154 CDD:293791 18/43 (42%)
WD40 repeat 164..200 CDD:293791 13/35 (37%)
WD40 repeat 212..253 CDD:293791 16/40 (40%)
WD40 repeat 260..297 CDD:293791 15/36 (42%)
WD40 repeat 303..327 CDD:293791 9/23 (39%)
PHA03247 <772..1172 CDD:223021 102/450 (23%)
Sec31 899..946 CDD:431930 9/50 (18%)
SRA1 1133..1265 CDD:429397 29/134 (22%)

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