Protein Alignment SEC31A and Sec31a

DIOPT Version :10

• Sequence 1: NP_001387083.1
• Gene: SEC31A / 22872
• HGNCID: 17052
• Length: 1251
• Species: Homo sapiens
• Sequence 2: XP_006535255.1
• Gene: Sec31a / 69162
• MGIID: 1916412
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1264
• Identity: 1150/1264 - (90%)
• Similarity: 1198/1264 - (94%)
• Gaps: 16/1264 - (1%)

Human     1 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65

Human    66 SHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDV 130
            |||||||||||:||||||||||||||||||||||||||||||||||||||||.||||||||||||
Mouse    66 SHRYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQKDKHTGPVRALDV 130

Human   131 NIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 NIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATV 195

Human   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHA 260

Human   261 RGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 RGILAVAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325

Human   326 GRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWI 390
            ||||||||||||.|||||||||||||||||||||||||||||||||||:||||||||||||||||
Mouse   326 GRISVYSIMGGSIDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQSAQHSIVLPLKKPPKWI 390

Human   391 RRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFI 455
            ||||||||||||||||||:|.:|..||||||::| .||||||||||:||:||.|||.||||||||
Mouse   391 RRPVGASFSFGGKLVTFESVAVPLQQGAEQQRRQ-PVFISQVVTEKDFLNRSAQLQHAVQSQGFI 454

Human   456 NYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDGANVALKD 520
            .||||||:|||||||||||||||||||:||||||||||||||||||:|||||||||||.:|||||
Mouse   455 GYCQKKIEASQTEFEKNVWSFLKVNFEEDSRGKYLELLGYRKEDLGQKIALALNKVDGPDVALKD 519

Human   521 SDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGTFNISVSGDIDGLITQALLTGNFESA 585
            ||||||||||||||||||||||.|||||:|.:||||:|||||||||||||||||:||||||||||
Mouse   520 SDQVAQSDGEESPAAEEQLLGERIKEEKQECDFLPSAGGTFNISVSGDIDGLITRALLTGNFESA 584

Human   586 VDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWR 650
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||:||||||||||||
Mouse   585 VDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKITRLITAVVMKNWREIVESCDLKNWR 649

Human   651 EALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHPL 715
            |||||||||||||||||||||||||||.||||||:||||||||||||||:||||||||||||.||
Mouse   650 EALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLRTQACLCYICAGNVERLVACWTKAQDGSSPL 714

Human   716 SLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIM 780
            |||||||||||||||||||||:||:|||.|||.||||||:||||||||||||||||||||||||:
Mouse   715 SLQDLIEKVVILRKAVQLTQALDTNTVGALLAEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIV 779

Human   781 QLRDRLCRAQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHVRIAPTVTTWS 845
            |||||||:|||:||:|.||.:.|||:|.|.||||||||||.||||||||||||||||||||||||
Mouse   780 QLRDRLCKAQGKPVSGQESSQSPYERQPLSKGRPGPVAGHSQMPRVQTQQYYPHVRIAPTVTTWS 844

Human   846 NKTPTALPSHPPAASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQP 910
            |||||||||||||||||||||||||||||||.|||.||.|..|||:||||.:|:|||||||||||
Mouse   845 NKTPTALPSHPPAASPSDTQGENPPPPGFIMQGNVIPNPAAPLPTAPGHMPSQLPPYPQPQPYQP 909

Human   911 AQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATSFP 975
            ||.|.|||||:|.||||||||||.|||||||||||..:||:||.|:|.|| ||||||||.|.||
Mouse   910 AQQYSFGTGGAAAYRPQQPVAPPASNAYPNTPYISPVASYSGQPQMYTAQ-QASSPTSSSAASF- 972

Human   976 PPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRT-------------GPQNGWN 1027
            ||||||||||||||||||||||||||||||||.||||||||||||             |||||||
Mouse   973 PPPSSGASFQHGGPGAPPSSSAYALPPGTTGTPPAASELPASQRTENQSFQDQASILEGPQNGWN 1037

Human  1028 DPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQ 1092
            |||||||||||||||||||||||||||||||.||||||.||||||.|.||||.:||||.||.|||
Mouse  1038 DPPALNRVPKKKKMPENFMPPVPITSPIMNPSGDPQSQGLQQQPSTPGPLSSHASFPQQHLAGGQ 1102

Human  1093 PFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDL 1157
            |||||||||.||||||||||||.|||||||||||.||||:|||:||||||||:||||||||||||
Mouse  1103 PFHGVQQPLAQTGMPPSFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPEEHLILKTTFEDL 1167

Human  1158 IQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTH 1222
            ||||||||||||||||||||||||||||||||||||||||.:|||:||||||||||||||::|||
Mouse  1168 IQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLSVHTH 1232

Human  1223 IVSTSNFSETSAFMPVLKVVLTQANKLGV 1251
            |||||||||||||||||||||:||:||||
Mouse  1233 IVSTSNFSETSAFMPVLKVVLSQASKLGV 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC31A	NP_001387083.1	WD40	13..332	CDD:475233	315/318 (99%)
		WD40 repeat	13..65	CDD:293791	51/51 (100%)
		WD40 repeat	70..119	CDD:293791	47/48 (98%)
		WD40 repeat	125..162	CDD:293791	36/36 (100%)
		WD40 repeat	172..208	CDD:293791	35/35 (100%)
		WD40 repeat	214..257	CDD:293791	42/42 (100%)
		WD40 repeat	263..302	CDD:293791	37/38 (97%)
		WD40 repeat	306..331	CDD:293791	24/24 (100%)
		ACE1-Sec16-like	<573..>696	CDD:449359	117/122 (96%)
		Atrophin-1	776..>1129	CDD:460830	303/365 (83%)
Sec31a	XP_006535255.1	WD40	13..332	CDD:475233	315/318 (99%)
		WD40 repeat	13..65	CDD:293791	51/51 (100%)
		WD40 repeat	70..119	CDD:293791	47/48 (98%)
		WD40 repeat	125..162	CDD:293791	36/36 (100%)
		WD40 repeat	172..208	CDD:293791	35/35 (100%)
		WD40 repeat	214..257	CDD:293791	42/42 (100%)
		WD40 repeat	263..302	CDD:293791	37/38 (97%)
		WD40 repeat	306..331	CDD:293791	24/24 (100%)
		ACE1-Sec16-like	<572..766	CDD:449359	181/193 (94%)
		PHA03247	<750..1132	CDD:223021	321/383 (84%)