DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SEC31A and Sec31

DIOPT Version :10

Sequence 1:NP_001387083.1 Gene:SEC31A / 22872 HGNCID:17052 Length:1251 Species:Homo sapiens
Sequence 2:NP_001286215.1 Gene:Sec31 / 35877 FlyBaseID:FBgn0033339 Length:1260 Species:Drosophila melanogaster


Alignment Length:1355 Identity:471/1355 - (34%)
Similarity:701/1355 - (51%) Gaps:206/1355 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65
            ||:||:.:|...||||||...|.||.||:|||.|:  :.|::||::..:.||.:.|::..|:.||
  Fly     1 MKIKELQKTVNIAWSPAQQQQILLAAGTAAQQFDS--NANSTLELYSPNFSDATYDLELRASVSS 63

Human    66 SHRYHKLIW---GPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRA 127
            .:::.||||   ||:.       ||:::.|.|.|.|.:|...|::||.:|.::.:.|||||.|..
  Fly    64 QYKFQKLIWSPVGPHP-------SGLIVGGCEAGQINIYSADKLLAGKEEPLLKRQDKHTGAVSG 121

Human   128 LDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGR 192
            ||.|.||.||:||.|:||||.||||||..|.|:||.||||.||:..:||||||||||||.. |.|
  Fly   122 LDFNPFQNNLLASCASESEILIWDLNNPETSMSPGTKTQPLEDVKNVAWNRQVQHILASVF-STR 185

Human   193 ATVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLE 257
            ..:|||||::.|||:||..:|:....:.|||:.|||:.||||||:.||:|:||||:|::|.:..:
  Fly   186 CVIWDLRKSQQIIKLSDSQSRVRWHAIEWHPEAATQVWLASEDDQAPVVQLWDLRYATAPAKTYQ 250

Human   258 NHARGILAIAWSMADPELLLSCGKDAKILCSNPNT----GEVLYELPTNTQWCFDIQWCPRNPAV 318
            .|.||:|.::|.:.|.:|::|||||.:|.|.||||    ||:|.|:.|...|..|:|:||||||:
  Fly   251 IHERGVLGMSWCLQDNDLMVSCGKDNRIYCWNPNTKIPEGEILSEVATTASWYSDVQFCPRNPAL 315

Human   319 LSAASFDGRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPL 383
            :::||.:|.:|:||:.|| |..|.| ..:|::.||..:|.|.. :|     ||||..| .:...|
  Fly   316 IASASLEGAVSIYSLHGG-THHLVQ-TANKIADSFPGMDQFAQ-EP-----IPQQATQ-VVYHDL 371

Human   384 KKPPKWIRRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQA 448
            ...|||::||.|.:|.||||||:|...             ...|.:.|:.||...:.|::.|:::
  Fly   372 AHAPKWMKRPCGVAFGFGGKLVSFNGT-------------SKTVKVQQLTTESALVDRANALERS 423

Human   449 VQSQGFINYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALALNKVDG 513
            :....:.:||:::.|.:..:..:.:|.|:|.|||.:.:.:.|.||||.|:|:..|....:.:.||
  Fly   424 LVDANYSDYCRQRADETPDQHGRYIWYFIKANFELNPKEEMLNLLGYNKDDIDSKFNKFIKETDG 488

Human   514 -------------ANVALKDS-----DQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGT 560
                         :.:...||     ||......:.|...:.:..|..| :.:..::|.......
  Fly   489 NSHSDVDTLTTRISTLTHSDSSEVECDQSTNYSTDNSQTQDNKFDGNAI-DSQNHNDFATPPRPQ 552

Human   561 FNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKI 625
            |.:......|.||.:|:||||.::||:|||...|:.:|:|:|...|.|.|.|||.:|..:.::::
  Fly   553 FKVPSGDHSDSLIAEAILTGNVDAAVELCLEAQRIPEALIIASTAGIETLNRTQTRYLLQQKNEL 617

Human   626 TRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQ--TQA 688
            :.:|:|:|.::|.:.|..|.:.:|:|||.|.|.::: .:...:|:.||.||.:|..|..:  ..|
  Fly   618 SHVISALVSRDWLDFVNRCTVDSWKEALVAALKHSE-RKVVDICERLGDRLLSECASSAEFTRNA 681

Human   689 CLCYICAGNVEKLVACW--TKAQDGSHP------LSLQDLIEKVVILRKAVQLTQAMDTSTVGVL 745
            .|||||||:::|||..|  .|..:..:|      ..||||.|.|:::.|::: .|.:.....| .
  Fly   682 MLCYICAGSIDKLVTAWYQLKRLEQQNPGYKPNTTELQDLAEMVMLMCKSLE-QQGISVDLAG-R 744

Human   746 LAAKMSQYANLLAAQGSIAAALAFLPD-----NTNQPNIMQ-LRDRLCRAQG------------- 791
            .|..:::|..|||:||::.|||.::..     ..::.:::| ||||:..|..             
  Fly   745 FAGFLTEYGGLLASQGALTAALQYITTLGGGAAASESDVLQSLRDRINNAVNLDYTQPQAAVAAA 809

Human   792 ----EPVAGHESPKIPYEKQQLPKGRP----GPVAGHHQMPRVQTQQYYP---HVRIAPTVTTWS 845
                :|..|..|...|.....:|.|:|    ...:...|:|.:||.  ||   ..:..|.:....
  Fly   810 PHGYQPTRGRGSFSQPQPSAPMPYGQPPNQYAQPSWPAQVPPLQTS--YPGAQQPQAPPQIFNPQ 872

Human   846 NKTPTALPSHPPAASPSDTQGENPPPPGFIMHGN----------VNPNAAGQLPTSPGHMHTQVP 900
            ...|..|...|...|.:.:.|..||..|....|.          ::|:.|.  |||...|     
  Fly   873 PVKPEPLAQPPRPLSNASSSGGPPPAGGASSSGGSGLSGRSKYVLDPSVAA--PTSSYGM----- 930

Human   901 PY-PQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPT--SNAYPNTPYISSASSYTGQSQLYAAQHQ 962
            || |.|.|...|  .|||.||.....| ||.:.||  |||: ||..|::|..| ..|.|..||..
  Fly   931 PYNPVPAPVPSA--VPFGGGGVPGPAP-QPASVPTYNSNAF-NTNPIAAAQPY-NPSPLMPAQQN 990

Human   963 ASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWN 1027
            ...|..:|..:.|||                     |:||    .:......|.     |..|||
  Fly   991 QFVPGVNPIETMPPP---------------------AVPP----VIQNVQRNPT-----PPPGWN 1025

Human  1028 DPPAL--NRVPKKKKMPEN----FMPPVPITSPIMNPLG--DPQSQMLQQQPSAPVPLS------ 1078
            |||||  :|.||.|.:.|.    |.|..|: .|..|..|  || ||.....|...||.:      
  Fly  1026 DPPALKSSRAPKPKPVVEPSAAIFHPLFPV-DPNQNQNGYVDP-SQYQHAAPLGGVPNTYYNPAA 1088

Human  1079 ------SQSSFPQPHLPGGQPFHGVQQP--------LGQTGMPPSFSKPNIEGAPGAPIGNTFQH 1129
                  .|....|.:|...||..|:|||        :|.|..|             |||.   |.
  Fly  1089 FNNNPQQQQQHQQSYLQPQQPAPGIQQPNWQGQQQTIGYTEQP-------------APIQ---QQ 1137

Human  1130 VQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLS 1194
            .|..|.|:  |.|:|:|::.|:|..|:|..|||.:..||:||||..|..||||.|||.||:..|:
  Fly  1138 RQPAPPKE--KPPLPEEYIYLQTVLEELKNRCLGATNDPRTKRKFVDVVKRLENLYDCLRDGKLT 1200

Human  1195 PTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKL 1249
            ||....|:.|.:.|:..:|:..:.:||.|...::|::.:.||..|||:|..|::|
  Fly  1201 PTTVQYLNQIVQYIQISDYANAMEIHTQIAFGTDFAQCAGFMQGLKVLLQSASEL 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEC31ANP_001387083.1 WD40 13..332 CDD:475233 159/325 (49%)
WD40 repeat 13..65 CDD:293791 22/51 (43%)
WD40 repeat 70..119 CDD:293791 17/51 (33%)
WD40 repeat 125..162 CDD:293791 23/36 (64%)
WD40 repeat 172..208 CDD:293791 22/35 (63%)
WD40 repeat 214..257 CDD:293791 21/42 (50%)
WD40 repeat 263..302 CDD:293791 19/42 (45%)
WD40 repeat 306..331 CDD:293791 12/24 (50%)
ACE1-Sec16-like <573..>696 CDD:449359 47/124 (38%)
Atrophin-1 776..>1129 CDD:460830 114/418 (27%)
Sec31NP_001286215.1 WD40 repeat 11..61 CDD:293791 22/51 (43%)
WD40 repeat 68..114 CDD:293791 17/52 (33%)
WD40 <80..329 CDD:475233 129/249 (52%)
WD40 repeat 119..156 CDD:293791 23/36 (64%)
WD40 repeat 166..202 CDD:293791 22/36 (61%)
WD40 repeat 209..250 CDD:293791 21/40 (53%)
WD40 repeat 256..296 CDD:293791 18/39 (46%)
WD40 repeat 303..328 CDD:293791 12/24 (50%)
ACE1-Sec16-like <570..>690 CDD:449359 46/120 (38%)
PHA03247 <802..1080 CDD:223021 91/323 (28%)

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