DRSC/TRiP Functional Genomics Resources

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Protein Alignment SEC31A and sec31a

DIOPT Version :10

Sequence 1:NP_001387083.1 Gene:SEC31A / 22872 HGNCID:17052 Length:1251 Species:Homo sapiens
Sequence 2:XP_009303363.1 Gene:sec31a / 266638 ZFINID:ZDB-GENE-020919-2 Length:1558 Species:Danio rerio


Alignment Length:1599 Identity:805/1599 - (50%)
Similarity:969/1599 - (60%) Gaps:389/1599 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     1 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLSDPSLDMKSCATFSS 65
            |||||::|||:|||||||.||||||.||||||||||||||||||||||||:|.:|.||||.:|||
Zfish     1 MKLKEINRTAIQAWSPAQQHPIYLAAGTSAQQLDATFSTNASLEIFELDLADSALAMKSCGSFSS 65

Human    66 SHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDV 130
            .||||||:|||:.::::|..|||||||||||||||||.|||||||.||:|.|::||||.||||||
Zfish    66 PHRYHKLVWGPHGIENQGLPSGVLIAGGENGNIILYDASKIIAGDSEVIILQSEKHTGAVRALDV 130

Human   131 NIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATV 195
            |.||:||||||.|||||||||||||::|||||.||||.|||||:|||:|||||||||||||:|:|
Zfish   131 NSFQSNLVASGGNESEIYIWDLNNFSSPMTPGPKTQPQEDISCVAWNKQVQHILASASPSGKASV 195

Human   196 WDLRKNEPIIKVSDHSNRMHCSGLAWHPDVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHA 260
            ||||||:.||||||||||||||||||:|:||||:||||||||:|||||||||||:|||:|||||.
Zfish   196 WDLRKNDLIIKVSDHSNRMHCSGLAWNPEVATQLVLASEDDRMPVIQMWDLRFATSPLKVLENHT 260

Human   261 RGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFD 325
            |||||||||:||||||||||||.:|||.||||.||||||||:||||||||||||||||||||:||
Zfish   261 RGILAIAWSVADPELLLSCGKDNRILCWNPNTAEVLYELPTSTQWCFDIQWCPRNPAVLSAAAFD 325

Human   326 GRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQHSIVLPLKKPPKWI 390
            |.||:|||||||.|.....|.|:|||||||:||||||:.|||||:||||:..|.:.|||||||||
Zfish   326 GHISIYSIMGGSNDNANNLQADQLSSSFGNMDPFGTGKTLPPLQLPQQTSPQSTITPLKKPPKWI 390

Human   391 RRPVGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFI 455
            ||||||||:|||||||.:|::..:.|  .||...|.|.|||||||.:|:.||:|||..:.:..|:
Zfish   391 RRPVGASFAFGGKLVTLDNIKPTAQQ--PQQTAAHVVHISQVVTETDFIHRSNQLQTTLNAGNFL 453

Human   456 NYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGYRKEDLGKKIALAL------------ 508
            .|||.||:..|.|||:.||||||||||:|:|.||||||||.||:|..|||.||            
Zfish   454 EYCQNKIETVQNEFERTVWSFLKVNFEEDARLKYLELLGYEKEELALKIASALEGNCKPKEADML 518

Human   509 ----------------------------------------------------------------- 508
                                                                             
Zfish   519 SIIPASIPLQHTTPAPDPLSDPLPDISNNPEPVLETQSEPDPDALLVQPRIEPKYASPPNLELHL 583

Human   509 ----------------------------------------------------------------- 508
                                                                             
Zfish   584 QFVNDPIFESTTVPSANTLQPHSQTLVDFTPPVDLTTLFDLTPPVDLTHSFDQTPPVGIAAPVDI 648

Human   509 --------------NKVDG------------ANVALKDSD------------------------- 522
                          .::|.            :|:||:.:|                         
Zfish   649 VTQVGPSGQVSSPEEQLDSLPLLTPSTCPQESNLALESTDLLLPTESTATMVPHQSSCGATTVEF 713

Human   523 ----------------------------------------------------------------- 522
                                                                             
Zfish   714 QQSVPITEQGFGVVQTEYLEPAQASTIGLHLASGCDPLDAPGLSPDILPQEAVSMQVLNVDPQLP 778

Human   523 -------------------------------------------------------QVAQSDGEES 532
                                                                   :.|.||.::.
Zfish   779 TQESDLMISVADLLNVSDCKLELQVEDVLGGDDPNNGRAKEETKLDEDKEEVLAEEEADSDLDDI 843

Human   533 PAAEEQLLGEHIKEEKEESEFLPS-SGGTFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRMA 596
            |..||    |.:.||...:|..|: :....|:.||.|||||||||||||::|:||:|||||||||
Zfish   844 PVNEE----EPVVEETSNTEVPPAPASDAINLKVSQDIDGLITQALLTGDYEAAVNLCLHDNRMA 904

Human   597 DAIILAIAGGQELLARTQKKYFAKSQSKITRLITAVVMKNWKEIVESCDLKNWREALAAVLTYAK 661
            |.||||||||.||||:||:|||:|::|||::||:|||||:|.:|:|:|||:||:||||||:||||
Zfish   905 DGIILAIAGGPELLAKTQRKYFSKTESKISKLISAVVMKDWLDILETCDLQNWKEALAAVMTYAK 969

Human   662 PDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVI 726
            |:||||||.|||:|||:..|..||.||||||||||.||:||:.|||.||...|||||:|:||||:
Zfish   970 PEEFSALCGLLGSRLESSEDVELQAQACLCYICAGTVEQLVSFWTKTQDSCSPLSLQELVEKVVV 1034

Human   727 LRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQG 791
            |::||:..|....:.:|.|||.||:|||:|||:|||:..|:::||.||.|.::.|||:||.||.|
Zfish  1035 LQRAVEKAQGAVPADMGALLAEKMNQYASLLASQGSLQTAISYLPTNTEQVSVQQLRERLSRALG 1099

Human   792 EPVAGHESPKIPYEK----QQLPKGRPGPVAGH-HQMPRVQTQ--------QYYPHVRIAPTVTT 843
            :    |:.|:.|...    |::.:.||..|... :..|:...|        |||...|.|.|||:
Zfish  1100 Q----HQHPQQPAAAVTGIQKMHQTRPAAVPMQTYSQPQPPAQPAAPAVPPQYYQQGRSATTVTS 1160

Human   844 WSNKTPTALPSHPPAASP-SDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQP 907
            |||:|||||||.|....| ||.||::.||    ..|..:| |...:|.|...|::|     |.|.
Zfish  1161 WSNQTPTALPSVPRQLVPSSDPQGDSTPP----AFGLQSP-AMASVPASTPFMYSQ-----QYQN 1215

Human   908 YQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPAT 972
            |.|.|.:....|...:|:| .|.|....:..|..|..|||:.|..|..|     .|||..|:|..
Zfish  1216 YPPVQQFTPSAGTPGIYQP-LPYASSAGSPLPPPPSSSSAAVYPPQFML-----SASSQASAPPQ 1274

Human   973 SFPPPP--SSGASFQHGGPGAPPSSSAYALPPG--TTGTLPAASELPASQRT------------G 1021
            ||.|||  |||..|||||||:|.|   |..|||  ..||....:.:||||||            |
Zfish  1275 SFCPPPAVSSGGCFQHGGPGSPTS---YLPPPGARAPGTQHEPALIPASQRTDGFYQETAWGLEG 1336

Human  1022 PQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQS----QMLQQQPSAPVPLSSQSS 1082
            |||||||||||:|..||||:|::|.||.|||:|||.||||||:    |.||.|...|    .||:
Zfish  1337 PQNGWNDPPALSRAAKKKKVPQHFTPPAPITAPIMAPLGDPQAPAGMQTLQPQQQVP----DQSA 1397

Human  1083 FPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEH 1147
            .|....|      ..|||||...  ||..:.|:|||||||||:..:.:|::||:||||||||:||
Zfish  1398 GPATFTP------IQQQPLGPRN--PSMPQGNMEGAPGAPIGDVIKPLQAIPTEKITKKPIPEEH 1454

Human  1148 LILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRN 1212
            ::||||||.|||:||::|:|||||||||||.||||.||||||||||||.|..||||:|.|||.|:
Zfish  1455 MVLKTTFEGLIQKCLTAASDPQTKRKLDDAHKRLELLYDKLREQTLSPAIIGGLHNMAHSIECRS 1519

Human  1213 YSEGLTMHTHIVSTSNFSETSAFMPVLKVVLTQANKLGV 1251
            |::||.:||||||.|||||||||||||||||||||||||
Zfish  1520 YADGLNIHTHIVSNSNFSETSAFMPVLKVVLTQANKLGV 1558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEC31ANP_001387083.1 WD40 13..332 CDD:475233 264/318 (83%)
WD40 repeat 13..65 CDD:293791 43/51 (84%)
WD40 repeat 70..119 CDD:293791 35/48 (73%)
WD40 repeat 125..162 CDD:293791 31/36 (86%)
WD40 repeat 172..208 CDD:293791 29/35 (83%)
WD40 repeat 214..257 CDD:293791 36/42 (86%)
WD40 repeat 263..302 CDD:293791 33/38 (87%)
WD40 repeat 306..331 CDD:293791 22/24 (92%)
ACE1-Sec16-like <573..>696 CDD:449359 91/122 (75%)
Atrophin-1 776..>1129 CDD:460830 162/386 (42%)
sec31aXP_009303363.1 WD40 repeat 13..69 CDD:293791 46/55 (84%)
WD40 repeat 71..118 CDD:293791 33/46 (72%)
WD40 <89..332 CDD:475233 206/242 (85%)
WD40 repeat 125..162 CDD:293791 31/36 (86%)
WD40 repeat 172..208 CDD:293791 29/35 (83%)
WD40 repeat 214..257 CDD:293791 36/42 (86%)
WD40 repeat 263..301 CDD:293791 32/37 (86%)
WD40 repeat 306..331 CDD:293791 22/24 (92%)
ACE1-Sec16-like <881..1078 CDD:449359 132/196 (67%)
PHA03247 <1093..1418 CDD:223021 148/359 (41%)
PRK10263 <1361..>1518 CDD:236669 101/168 (60%)

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