Protein Alignment SEC31A and sec31

DIOPT Version :10

• Sequence 1: NP_001387083.1
• Gene: SEC31A / 22872
• HGNCID: 17052
• Length: 1251
• Species: Homo sapiens
• Sequence 2: NP_595582.1
• Gene: sec31 / 2541273
• PomBaseID: SPBC8D2.20C
• Length: 1224
• Species: Schizosaccharomyces pombe
• Alignment Length: 1367
• Identity: 363/1367 - (26%)
• Similarity: 573/1367 - (41%)
• Gaps: 307/1367 - (22%)

Human     1 MKLKEVDRTAMQAWSP--AQNHPIYLA----TGTSAQQLDATFSTNASLEIFELDLSDP------ 53
            |:||::.:||..||||  ..::...||    |||...:...|        :.||...:|
pombe     1 MRLKDISKTATLAWSPRGVNDNQALLALGGYTGTEGSKNSDT--------LLELWNENPESQKPV 57

Human    54 -SLDMKSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDK-EVVIA 116
             |:|:|:        |::.|.|........|.::|.|    |:|.|..:||:.|:..|: ...||
pombe    58 GSIDVKT--------RFYDLAWEKSLDKPMGVIAGSL----EDGGIGFWDPAAILKSDEASASIA 110

Human   117 ----QNDKHTGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGA--KTQPPEDISCIA 175
                :|....||   ||.|..|.||:|||.|:.::::||:.:   |..|.|  |.....::..::
pombe   111 TYKSENGSILGP---LDFNRLQPNLLASGDNKGDVWVWDIKH---PQQPFALPKQNRSSEVHVVS 169

Human   176 WNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRMHCSG----------LAWHPDVATQMV 230
            ||.:|.|||||.:.:...||||::....::.:|    .:..:|          :||||:.||::.
pombe   170 WNNKVSHILASGNATEYTTVWDVKLKRQVLNLS----YLGAAGVSAATGAVNSIAWHPNNATRLA 230

Human   231 LASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEV 295
            .|.:|:|.|:|..||||..:.|..:|..|.:..|:::|...||..|||.|||.:.:..|..|||.
pombe   231 TAIDDNRNPIILTWDLRQPTVPQNILTGHQKAALSLSWCPEDPTFLLSSGKDGRAMVWNVETGES 295

Human   296 LYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQVDKLSS-----SFGN 355
            |...|.:..|.....|||.|...::.||.:|::|::||...:||..::..:...:|     .|.|
pombe   296 LGSFPRSGNWYTKSSWCPSNSNRVAVASLEGKVSIFSIQSTNTDKSQEASIKGATSIDDNEFFNN 360

Human   356 LDPF-GTGQPLPPLQIPQQTAQHSIVLPLKKPPKWIRRPVGASFSFGGKLVTF----ENVRMPS- 414
            |... |:.:|             |..|||  .|||.:.||||.|.|..|:|:|    :.|.:.|
pombe   361 LPSIAGSQEP-------------SFSLPL--APKWFKVPVGARFGFPNKIVSFSPNSKEVTITSA 410

Human   415 HQGAEQQQQQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQKKIDASQTEFEKNVWSFLKV 479
            ....||.:.:.....::..||||                ..::|||.::.|.:|.|...|..|..
pombe   411 PDEVEQDEAKSFHSSAKFQTEKE----------------ITDFCQKGVEESASEEEAINWKLLMA 459

Human   480 NFEDDSRGKYLELLGYR----KEDLGKKIALALNKVDGANVALKDS---DQVAQSDGEESPAAEE 537
            ..:..||.|:.|||||:    |.|...      :||| .:|| |||   ::::::...|:...:.
pombe   460 VSKRASRSKFAELLGYKTLKPKNDEDD------SKVD-ESVA-KDSTTPNELSKNANNENYDDDS 516

Human   538 QLLG---EHIKE----EKEESEFLPSSGGTFNISVSGDIDGLITQALLTGNFESAVDLCLHDNRM 595
            ...|   |.::|    :|:::|.:..|...||...| |::..||:|||||:..|||..||.:.::
pombe   517 SFYGKLAESVQEVSIADKKDAEIVKDSFKIFNPEDS-DLEKNITEALLTGDVLSAVKACLEEKKI 580

Human   596 ADAIILAIAGGQELLARTQKKYFAKSQSK--ITRLITAVVMKNWKEIVESCDLKNWREALAAVLT 658
            ::|:.|:..||:|.....:..::...:.|  ..||...:...:.:.:|::.::..|::....:.|
pombe   581 SEALFLSTFGGKECRKCVRDAFYELQEHKPSYMRLSACIADNDLQNVVDNAEVSEWKDIFVFICT 645

Human   659 YAKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLVACWTK------------AQDG 711
            ||..|||:.||..||.|||:..|......|..|||.:.:::.....|.|            :..|
pombe   646 YATDDEFAPLCSTLGQRLEDLEDEKSIRSAEFCYIASKSLQSYANLWLKQLATSTKTSKAASAYG 710

Human   712 SHPLSLQDLIEKVVILRKAV-----QLTQAMDTSTVG---VLLAAKMSQYANLLAAQGSIAAALA 768
            ::...|..|::||.:.|..|     :|:...|....|   |.:|     ||.:|:|.|....|::
pombe   711 AYVEQLTKLMDKVSMFRSIVVYKDDELSATKDWKLAGLYEVYIA-----YAKILSASGKFDDAMS 770

Human   769 FL-------PDNTNQ-------------PNIMQLRD--------RLCRAQG------------EP 793
            :|       |....:             |.|.|::.        :..:|..            .|
pombe   771 YLNLVPTEFPGAKEEIQRLTMLLEPHAVPPIHQIKQTGYAPVQPKTSQASSILPTVPRTTSYTSP 835

Human   794 VAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPA 858
            .|...|...|.:...||.......||.:..|.:   ...|..|.||::....:..|.|..:.|.|
pombe   836 YATTSSHITPADVHPLPPPSTSTTAGWNDAPML---GQLPMRRAAPSMAPVRSPFPGASSAQPAA 897

Human   859 ASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHMH-------TQVPPYPQ---PQPYQPAQP 913
            .|.:.:....||||.........|..|...|...|..:       |:|||..|   |.||.|.
pombe   898 MSRTSSVSTLPPPPPTASMTASAPAIASPPPPKVGETYHPPTASGTRVPPVQQPSHPNPYTPV-- 960

Human   914 YPFGTGGSAMYRPQQPVA-----PPTSNAYPNTPYISSASSYTGQSQLYAAQHQASSPTSSPATS 973
                       .||.|||     ..:.|..|:.||...|               .:|.|.:||.:
pombe   961 -----------APQSPVAAASRISSSPNMPPSNPYTPIA---------------VASSTVNPAHT 999

Human   974 FPPPPSSGASFQHGG-----PGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALN 1033
            :.|         |||     |...|::....|||            .||||....    :||.::
pombe  1000 YKP---------HGGSQIVPPPKQPANRVVPLPP------------TASQRASAY----EPPTVS 1039

Human  1034 RVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQP-SAPVPLSSQSSFPQPHLPGGQPFHGV 1097
             ||....:..:..|.:|..|..:.|:...:.|:.|..| |..:|.||..|.|.           :
pombe  1040 -VPSPSALSPSVTPQLPPVSSRLPPVSATRPQIPQPPPVSTALPSSSAVSRPP-----------I 1092

Human  1098 QQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDL---IQ 1159
            ....|::....|.|.|..     .|.|:              :..||..   |:..:|.|   :|
pombe  1093 ATSAGRSSTAASTSAPLT-----YPAGD--------------RSHIPGN---LRPIYEMLNAELQ 1135

Human  1160 RCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIV 1224
            | :|.:..||..|.:.|..|||..|:|:|....||..:|..|..:|.|:...:|.....:.|:||
pombe  1136 R-VSQSLPPQMSRVVHDTEKRLNMLFDRLNSNVLSKPLTDELLALATSLNAHDYQTASNIQTNIV 1199

Human  1225 ST 1226
            :|
pombe  1200 TT 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEC31A	NP_001387083.1	WD40	13..332	CDD:475233	107/348 (31%)
		WD40 repeat	13..65	CDD:293791	16/64 (25%)
		WD40 repeat	70..119	CDD:293791	14/53 (26%)
		WD40 repeat	125..162	CDD:293791	13/36 (36%)
		WD40 repeat	172..208	CDD:293791	12/35 (34%)
		WD40 repeat	214..257	CDD:293791	17/52 (33%)
		WD40 repeat	263..302	CDD:293791	16/38 (42%)
		WD40 repeat	306..331	CDD:293791	8/24 (33%)
		ACE1-Sec16-like	<573..>696	CDD:449359	40/124 (32%)
		Atrophin-1	776..>1129	CDD:460830	89/406 (22%)
sec31	NP_595582.1	WD40	<11..335	CDD:441893	109/353 (31%)
		WD40 repeat	11..62	CDD:293791	14/58 (24%)
		WD40 repeat	67..114	CDD:293791	14/50 (28%)
		WD40 repeat	119..157	CDD:293791	17/43 (40%)
		WD40 repeat	166..202	CDD:293791	12/35 (34%)
		WD40 repeat	216..257	CDD:293791	16/40 (40%)
		WD40 repeat	263..300	CDD:293791	15/36 (42%)
		WD40 repeat	306..331	CDD:293791	8/24 (33%)
		PHA03247	<780..1110	CDD:223021	88/397 (22%)
		SRA1	1072..1217	CDD:429397	43/164 (26%)