DRSC/TRiP Functional Genomics Resources

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Protein Alignment SEC31A and sec-31

DIOPT Version :10

Sequence 1:NP_001387083.1 Gene:SEC31A / 22872 HGNCID:17052 Length:1251 Species:Homo sapiens
Sequence 2:NP_502144.1 Gene:sec-31 / 178060 WormBaseID:WBGene00011338 Length:1083 Species:Caenorhabditis elegans


Alignment Length:1355 Identity:296/1355 - (21%)
Similarity:489/1355 - (36%) Gaps:381/1355 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     1 MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFST--------NASLEIFELDLSDPSLDM 57
            |..|...|:.:..|||.......|.....||..|.|.::        .|| ||:|.....|::  
 Worm     1 MSSKLYSRSGVFVWSPRGIQKKGLIVADFAQFFDPTATSIEPKIDFLPAS-EIYEKSNLAPNV-- 62

Human    58 KSCATFSSSHRYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGDK-EVVIAQNDKH 121
                :.::::|:::|.|  ..:.|....:|::..|.|:|.::.:|..|.|.... ||::::.|.|
 Worm    63 ----SHATNYRFNELAW--TSLCSDAHPNGIIAGGTEDGTVVFFDADKFIKNQSLEVLLSRRDHH 121

Human   122 TGPVRALDVNIFQTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILAS 186
             |.|..:||: .....:|||....:|.:||..|..||.:||:... |:.:..:.||.:.:.:.||
 Worm   122 -GHVLTIDVS-RDGRWMASGGGSGQILLWDCANLKTPFSPGSPNF-PDQVKLLRWNLKNESVFAS 183

Human   187 ASPSGRATVWDLRKN-EPIIKVSDHSNRMHC--SGLAWHPDVATQMVLASEDDRLPVIQMWDLRF 248
            .| |.|.:.||||:| .|:::.::...   |  |.|:|:|..|:|::::|:.....|||.||.||
 Worm   184 IS-SRRVSFWDLRRNGSPVLEFAEIPG---CDWSSLSWNPSDASQLIVSSQSQHASVIQKWDSRF 244

Human   249 ASSPLRVLENHARGILAIAWSMADPELLLSCGKDAKILCSNPNTGEVLYELPT-NTQWCFDIQWC 312
            .|:|::...:|..||.::.|:.||..|::|.|.|.:::..|..|.|||..:.: ...|..:::|.
 Worm   245 TSTPVKEYRHHNMGITSVDWNKADDRLVISSGCDGQVVIWNHETSEVLGGVGSLQGDWIRNVKWN 309

Human   313 PRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQVDKLSSSFGNLDPFGTGQPLPPLQIPQQTAQH 377
            ...|:..:...|...:                |:..|:|         .|.|.|...:.......
 Worm   310 EEEPSQFAIQYFQHPV----------------QISSLTS---------LGSPQPGADVLAARISD 349

Human   378 SIVLPLKKPPKWIRRP-VGASFSFGGKLVTFENVRMPSHQGAEQQQQQHHVFISQVVTEKEF--- 438
            ..|      |.|.|.| :|:|.:.||:|.||    ..|:. |..||..|:|.|..:|.|.:.   
 Worm   350 QFV------PAWHRAPLIGSSIALGGRLATF----WKSYD-AMTQQWHHNVEIETIVPENDVGVN 403

Human   439 -LSRSDQLQQAVQSQGFI----NYCQKKIDASQTEFEKNVWSFLKVNFEDDSRGKYLELLGY--- 495
             :::...::...::.|:.    .|......:.:.:..:.||..|....|...|.|.|..||.   
 Worm   404 DIAQYLHIKDDKRNLGWYLHERAYAPSSDTSEEADLTRKVWLILLALQEGAGRTKMLNYLGLVES 468

Human   496 RKEDLGKKIALALNKVDGANVALKDSDQVAQSDGEESPAAEEQLLGEHIKEEKEESEFLPSSGGT 560
            :.|:..:|.|.:                 |.|:....|.|                  :|.....
 Worm   469 QDEEFSEKNAAS-----------------AVSNPNIQPTA------------------IPDRSAR 498

Human   561 FNISVSG---DID---GLITQALLTGNF----ESAVDLCLHDNRM--ADAIILAIAGGQELLART 613
            ....|||   |||   ..:.:...:.|:    .|..||.||..|.  .:.|.:.|:..|.:.|..
 Worm   499 STSVVSGADTDIDIPEVTVIERCSSVNWSTLDNSGWDLLLHTIRQDHLEVIRVLISSNQHVAAMM 563

Human   614 -----------------QKKYFAKSQSKITRLITAV---------------------VMKNWKEI 640
                             .||:  .:.|.::.:|.|:                     |.:....|
 Worm   564 YAAQHETDHLAMILDDYNKKF--NNSSPLSSIILALSSSSSANKTEITPSKQSSEQEVSQQIGSI 626

Human   641 VESCDLKNWREALAAVLTY---AKPDEFSALCDLLGTRLENEGDSLLQTQACLCYICAGNVEKLV 702
            :::...:.|.|.|..::.:   |.....:|.|  :|.|...:|..|   :||:.::.||:::.|:
 Worm   627 LQTFPDQKWSELLGFIIAHESNATDIRLAAKC--IGKRWLEQGKPL---RACIAFLIAGDIDHLL 686

Human   703 ACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLLAAKMSQYANLLAAQGSIAAAL 767
            ...|.       .:|.|.:::.:||.:..:..:..|.      |...:..:||.|..||:.:.|.
 Worm   687 LANTS-------FTLVDRLKQALILHQVSKGAKYSDG------LEKLIMNFANELLIQGAGSVAW 738

Human   768 AFLPDNTNQPNIMQLRDRLCR--AQGEPVAGHESPKIPYEKQQLPKGRPGPVAGHHQMPRVQTQQ 830
            ..:..:.|....||.....|.  |.|....|.:.|..|::           ||    :||.|   
 Worm   739 NLVKWSQNGSAEMQELQWTCYNVAGGRDCTGDQPPFNPFD-----------VA----LPRAQ--- 785

Human   831 YYPHVRIAPTVTTWSNKTPTALPSHPPAASPSDTQGENPPPPGFIMHGNVNPNAAGQLPTSPGHM 895
                                    .||...|:.|                               
 Worm   786 ------------------------QPPIVQPTRT------------------------------- 795

Human   896 HTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSASSYTGQSQLYAAQ 960
                  |.||.|..|    |....|...|.|.....||....|.|....|:.:.....|..|   
 Worm   796 ------YQQPAPIPP----PNLVNGFNPYNPSHSQCPPPPMDYSNNRRNSNLTPMPPSSTFY--- 847

Human   961 HQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNG 1025
                   .:|:....|||:..|:.       |||.             |.|...|         |
 Worm   848 -------QTPSWDHKPPPTMPANM-------PPSK-------------PVAPVTP---------G 876

Human  1026 WNDPP--ALNRV----PKKKKMPENFMPPVPITSP--------IMNPLGDPQSQML--------- 1067
            |||||  ||...    ||:..|..|:.|.....:|        :....|..|:.|.         
 Worm   877 WNDPPPMALKPTTVAQPKQNVMEINWKPIETAQAPGGMMTGQQLNGFAGGYQNVMTNGIQGMSIH 941

Human  1068 QQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQS 1132
            .||.||     :.|:||.|                                      |::|...:
 Worm   942 NQQSSA-----ASSAFPSP--------------------------------------NSYQQRPA 963

Human  1133 LPTKKITKKPI---PDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEF-LYDKLREQTL 1193
            .....:...||   |::..|:: ....|.|..:.:|.......|..|...|::. |..:|....|
 Worm   964 SAASVVAPAPIQLSPEDEKIIE-PINTLAQCIIENARIQARMEKAQDLRTRIQAELSPRLAANRL 1027

Human  1194 SPTITSGLHNIARSIETRNYSEGLTMHTHIVSTS-NFSETSAFMPVLKVVLTQAN 1247
            ||.....|.::|..:..|...|...:...:...| :|.|.|:|:|.||.:|:.|:
 Worm  1028 SPESKQHLTHMAYFVSMRQIREAQAVVAQMARNSGDFVEISSFLPALKSLLSLAS 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEC31ANP_001387083.1 WD40 13..332 CDD:475233 94/331 (28%)
WD40 repeat 13..65 CDD:293791 14/59 (24%)
WD40 repeat 70..119 CDD:293791 12/49 (24%)
WD40 repeat 125..162 CDD:293791 12/36 (33%)
WD40 repeat 172..208 CDD:293791 13/36 (36%)
WD40 repeat 214..257 CDD:293791 17/44 (39%)
WD40 repeat 263..302 CDD:293791 13/39 (33%)
WD40 repeat 306..331 CDD:293791 3/24 (13%)
ACE1-Sec16-like <573..>696 CDD:449359 30/169 (18%)
Atrophin-1 776..>1129 CDD:460830 70/377 (19%)
sec-31NP_502144.1 WD40 repeat 71..119 CDD:293791 12/49 (24%)
WD40 <83..308 CDD:441893 73/231 (32%)
WD40 repeat 124..160 CDD:293791 12/36 (33%)
WD40 repeat 169..205 CDD:293791 13/36 (36%)
WD40 repeat 212..253 CDD:293791 16/40 (40%)
WD40 repeat 259..296 CDD:293791 13/36 (36%)
Atrophin-1 <767..>904 CDD:460830 51/258 (20%)

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