Protein Alignment NLGN1 and CG10175

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 182/629 - (28%)
• Similarity: 275/629 - (43%)
• Gaps: 132/629 - (20%)

Human    54 LVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118
            :..|:.||:||..::..:...|....|.|:.|.|||||.|||:..||..|||.||:|::....||
  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219

Human   119 -QNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAE 182
             :|:|                ||....     .||||::|::.       |:...||    :.||
  Fly   220 HKNMI----------------LDTFKG-----DEDCLFVNVFT-------TQMPKDD----ESAE 252

Human   183 DEDIRDSGGPK-PVMVYIHGGSYMEGTGN--LYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQA 244
            .        || ||||::|||.:..|:||  ||....|.: .:::::|:|||||.||||:.|..
  Fly   253 Q--------PKLPVMVWLHGGGFSFGSGNSFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAGPD- 307

Human   245 AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLF 309
            |.||.||.|.:.||:|..:||..|||||.::|:||..||.|.|.||.|         |:..||||
  Fly   308 APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLL---------SSQAKGLF 363

Human   310 QRAIAQSGTALSSWAVSFQPAKYARMLATKVG-CNVSDTVELVECLQKKPYKELVD-------QD 366
            .|||:|||:||:.|::|...::.|..||..:| ...:.|.::::.|::.|..:||:       .:
  Fly   364 HRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAE 428

Human   367 IQPARYHIAFGPVIDGDVIPDDPQILMEQGEFL-------------NYDI--MLGVNQGEGLKFV 416
            .|.....:.|.||::|....|..:....:..||             |.|:  |.|.|..|.:.|:
  Fly   429 DQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFI 493

Human   417 ENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFT 481
            ..:..:...:|..:.||  ...|.......|..|.:...|:..|.  ..:|........::||.|
  Fly   494 RRLRKNPQLLSIIENDF--GRLVPQDLNVTESHDRVTREIRSFYL--GSKHVGIESVDEMIALLT 554

Human   482 DHQWVAPAVATADLHSNFG-SPTYFYAF--------YHHCQTDQVPAWADAAHGDEVPYVLGIPM 537
            |..::.....||..|:.|| :|.|.|.|        |........|.   ..||||:.|
  Fly   555 DLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPG---VCHGDELGY------ 610

Human   538 IGPTELFPCNF-------SKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW 595
                 ||...|       ...:|.:...::..||||||.|.|.             |:..:.:..
  Fly   611 -----LFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPT-------------PDSEDPMLT 657

Human   596 TRYSQKDQL-------YLHIGLKPRVKEHYRANKVNLWLELVPH 632
            |:::..|..       |:.|.....:|.:....:...|.|:..|
  Fly   658 TKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQH 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	179/621 (29%)
CG10175	NP_001287487.1	COesterase	155..695	CDD:395084	179/621 (29%)