Protein Alignment NLGN1 and Nlg4

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Alignment Length: 987
• Identity: 297/987 - (30%)
• Similarity: 429/987 - (43%)
• Gaps: 288/987 - (29%)

Human    54 LVATNFGKIRGIKKELNN-EILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117
            :|.|.:|::.|:...|:: ..|..|..|||||||.|||.:.||.|...|:||..||.:.:::|||
  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107

Human   118 PQNIIDGRLPEVM--------LPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174
            ||     |||.:.        :|......|..:..::::|||||||||::.|.
  Fly   108 PQ-----RLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------ 155

Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239
               |.||.::.:       ||:|:|||.|:...:||.||||||||||.|:|:|:|||||:||||:
  Fly   156 ---NAGANEKKL-------PVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLN 210

Human   240 TGD----QAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNR 300
            ...    .|...||||:|.:.||.|..:||..|||||..:|:.|.|.|.:|:|.|..|
  Fly   211 ANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTS------- 268

Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV-----ELVECLQKKPYK 360
             ....:|||.|||..||:|.||||:...|..:|..||.:|.|.:.|.:     ::|:||:..|.:
  Fly   269 -PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLE 332

Human   361 ELVDQDIQPARYHIAFGPVIDGDVIP--------DDPQILMEQ---------------------- 395
            :|...|||...:..:|||.:||.||.        ||   ||.:
  Fly   333 DLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARNSRRSSADSGFQSSAGGGGGQG 394

Human   396 -----------------GEF-------LN----YDIMLGVNQGEGL-KFVENIVDSDDGISASDF 431
                             |.|       :|    ||::.||..||.: :|..:  |..:|......
  Fly   395 GGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAH--DIQNGFEGERR 457

Human   432 DFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR--HNPETRRKTLLALFTDHQWVAPAVA 491
            |..:..:|.|.|.|.     |.|   ||...|||| ||  .:|...|.|.:|..:|.|:|||.|.
  Fly   458 DKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVR 516

Human   492 TADL-----------HSNFGSP------------------TYFYAFYHHCQTDQVPAWADAAHGD 527
            ..|:           .|..|||                  .|||.|.:..:....|......||:
  Fly   517 AGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGE 581

Human   528 EVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFE 591
            ::||:.|.|::.....||.|::|::..||..||.:|||||:||:||:...||:.. :..:.|||.
  Fly   582 DLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFR 646

Human   592 EVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH---------------NLNDISQ 641
            .:.|..|....|.||.||:|||:|.|:||:::::||.|:|.||               |.:|:..
  Fly   647 SITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDL 711

Human   642 Y----------TST--------------------------------------------------- 645
            |          .||
  Fly   712 YEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNN 776

Human   646 --TTKVP------STDITFRPT---RKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVT 699
              ||.:|      |:...|.||   ..:|..:.|.|..|              ....|||.||||
  Fly   777 MYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAA--------------GYAAYSTALSVT 827

Human   700 IAVGASLLFLNILAFAALYYKKDKRRHDVH--RRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDH 762
            ||:|.|||.||:|.||.:||::||.|.:|.  ::...||:....:.:..|    .::..|..:.|
  Fly   828 IAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE----PIKHAHYHMGH 888

Human   763 ECES------IHPHE-------VVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPL 814
            ...|      :..|:       ::|:.|     ..|...:.:||....|:   :..||  |:|..
  Fly   889 SQSSANVIVDVESHQDQAGQAAMLLQAA-----AAAAAAAANDVKPPPPH---ICSNT--GMQQQ 943

Human   815 HTFNTFTGGQNN 826
            ......:||..|
  Fly   944 QQVGGGSGGALN 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	231/683 (34%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	231/683 (34%)