Protein Alignment NLGN1 and Ace

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_476953.1
• Gene: Ace / 41625
• FlyBaseID: FBgn0000024
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 179/652 - (27%)
• Similarity: 289/652 - (44%)
• Gaps: 97/652 - (14%)

Human    25 LGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVA-TNFGKIRGIKKELNNEILGPVIQFLGVPYAAP 88
            |..|||:.:...|:.:.| ||.....:|.||. |:.|.:||....:...   .|..:.|:|||.|
  Fly    15 LPLPLTIPLPLVLVLSLH-LSGVCGVIDRLVVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKP 75

Human    89 PTGERRFQPPEPPSPWSDIRNATQFAPVCPQ---NIIDGRLPEVMLPVWFTNNLDVVSSYVQDQS 150
            |..:.||:.|.|..||..:.:||:.:..|.|   ....|...|   .:|..|.         :.|
  Fly    76 PVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSGE---EIWNPNT---------NVS 128

Human   151 EDCLYLNIYVPTEDGPLTKKQTDDLGDNDG-------AEDEDIRDSGGPK------PVMVYIHGG 202
            |||||:|::.|.:     .:.....|.|.|       |:.:.:..:|.|:      |::::|:||
  Fly   129 EDCLYINVWAPAK-----ARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGG 188

Human   203 SYMEGTGNL--YDGSVLASYGNVIVITVNYRLGVLGFL-------STGDQAAKGNYGLLDLIQAL 258
            .:|.|:..|  |:..::|:.|||||.:..||:|..|||       |...:.|.||.||.|...|:
  Fly   189 GFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAI 253

Human   259 RWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSW 323
            ||..:|...|||:|..:|:||..||.|.||...:|..         |:||.:|.:.||||..:.|
  Fly   254 RWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPV---------TRGLVKRGMMQSGTMNAPW 309

Human   324 A--VSFQPAKYARMLATKVGCNVS----DTVELVECLQKKPYKELVDQDIQPARYHIAF--GPVI 380
            :  .|.:..:..:.|.....||.|    :...::.|::....|.:..|........::|  .|.|
  Fly   310 SHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTI 374

Human   381 DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV----ENIVDSDDGISASDFDFAVSNFVDN 441
            ||..:|.||..||:..:..:|||::|..:.||..|:    .:..|.||..:.....:.  ..::|
  Fly   375 DGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNN 437

Human   442 LYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFY 506
            ::|  :.....||.|.|.||.|......:.:::...|: .||.:..|....|...:..|:..::|
  Fly   438 IFG--KATQAEREAIIFQYTSWEGNPGYQNQQQIGRAV-GDHFFTCPTNEYAQALAERGASVHYY 499

Human   507 AFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGD 571
            .|.|...|.....|....||||:.|..|.|:....:..|........|||||:     .|||||:
  Fly   500 YFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI-----EFAKTGN 559

Human   572 PNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYR---ANKVNLWLELVPHL 633
            |.|                :...|..:|::|.:|.......::::..|   |.:.:.|.:.:|.:
  Fly   560 PAQ----------------DGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608

Human   634 HN 635
            .:
  Fly   609 RS 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	169/614 (28%)
Ace	NP_476953.1	COesterase	43..601	CDD:395084	168/612 (27%)