Protein Alignment NLGN1 and CG4757

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 166/683 - (24%)
• Similarity: 258/683 - (37%)
• Gaps: 237/683 - (34%)

Human    37 LLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPP 101
            ||.:..|||.::|       |..|::||  ..|.:.:......|.|:.||.||.|:.||..|:|.
  Fly    12 LLASSSVLSIEVD-------TELGRVRG--ANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPV 67

Human   102 SPWS-DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDG 165
            .||| .|.:|::..|:|||             .|  :|:       .|.|||||.||:|.
  Fly    68 KPWSPKIFDASEDGPMCPQ-------------PW--DNM-------TDVSEDCLRLNVYT----- 105

Human   166 PLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGG---------SYMEGTGNLYDGSVLASYG 221
                                 :|..|.:||:|::|.|         .|:.|..:..|       .
  Fly   106 ---------------------KDLKGRRPVIVFLHPGGFYVFSGQSKYLAGPEHFMD-------R 142

Human   222 NVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSC 286
            :.:::::|||||.||||:||.:.|.||.||.|.:.||||..::|..|||||..:|:.|..||...
  Fly   143 DCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSIS 207

Human   287 VNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKY-------ARMLATKVGCNV 344
            |.|..||..|         :|||.|.|..|       |..:.|.||       |:..|..:.|..
  Fly   208 VALHMLSPMS---------RGLFHRGICMS-------AAPYGPVKYKDNDLQLAKRQAGLLKCPQ 256

Human   345 SDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPD----DPQILME-------QGEF 398
            ....|:|||:::|||.:.|  ......:...:.||::..::.:    ..:.|:|       :|:|
  Fly   257 ESIGEMVECMRRKPYLDYV--STYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDF 319

Human   399 LNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYT-D 462
            ....::.|:                     ::|:|....|.          |:..|:|...|. |
  Fly   320 HKVALITGI---------------------TEFEFLSGAFF----------DLRNESIVNRYNRD 353

Human   463 W------------------------ADRHNPETRRK------------------------TLLAL 479
            |                        .:::.||:..|                        ..|.|
  Fly   354 WEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQL 418

Human   480 FTDHQWVAPAVATADLHSNFGSPTYFYAF-----YHHCQTDQVPAWADAAHGDEVPYV----LGI 535
            .:.|                 :|.|.|.|     |...:...........|.||:.|:    |.|
  Fly   419 MSPH-----------------TPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLI 466

Human   536 PMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRF-EEVAWTRYS 599
            |::...:  |.||      :..::...|..||:.|||           |.|.:.: :.:.|..|:
  Fly   467 PLLKRED--PENF------MIELLTRMWIEFAQKGDP-----------HNKNDEYLKGLNWPLYN 512

Human   600 QKDQLYLHIGLKPRVKE-HYRANKVNLWLELVP 631
            .:|:.||.||.....|. .:..|:..:|.:|.|
  Fly   513 AQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	157/661 (24%)
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	159/668 (24%)