Protein Alignment NLGN1 and Nlg1

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 954
• Identity: 265/954 - (27%)
• Similarity: 405/954 - (42%)
• Gaps: 233/954 - (24%)

Human    42 HVLSQKLDDVDPLVATNFGKIRGIKKELN-NEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWS 105
            ||:..||..... :....|::.||.:... ...|..|.||||:|||..|||.|||.||..|.||.
  Fly   146 HVVPDKLQYTQE-IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQ 209

Human   106 DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTN-------NLDVVSSYVQDQSEDCLYLNIYVPTE 163
            .::.|....|||||     :||: :.|....|       :|..:..|::.:||||||||:|||.|
  Fly   210 GLKIARHLPPVCPQ-----KLPD-LSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHE 268

Human   164 DGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITV 228
            :...|.||                     ..|:||:||.|:...:||.||||||:|||.|||:||
  Fly   269 EPQSTPKQ---------------------YAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTV 312

Human   229 NYRLGVLGFLSTGDQAAK-GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTL 292
            ||||||||||.....|.. .||.|||.|.||.|..|||..||||..|:|:.|...|.:|||.|.:
  Fly   313 NYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMV 377

Human   293 SHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVE------LV 351
            |..:         .|||.|||..||:|:|.||.|.|..:....:|..:.|.:::.||      |:
  Fly   378 SPVA---------SGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLL 433

Human   352 ECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGLK 414
            :||:.:.|::::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|...
  Fly   434 DCLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYH 498

Human   415 FVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDV-----LRETIK---FMYTDWADRHNPET 471
            .:..:. .::|:..::.|..:..::.:.:      |:     |..|:|   .||.:.....|.|
  Fly   499 TLAALA-LEEGLRENERDNLLRFYMQSRF------DIRPDLALAATLKKYQDMYNNPIKATNLE- 555

Human   472 RRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIP 536
            .|..:|.:.:|.:.|.|.:.|...|::.....|.|.|.|:..|........:..|:|:.::.|.|
  Fly   556 HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAP 620

Human   537 M--IGPTELFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVA 594
            :  .||   ||. |::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.
  Fly   621 LAAAGP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLD 678

Human   595 WTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDI----- 654
            |..::::.|.||:||:.|.|...||...:|.|.:.:|  ..||.|:.......| |..::
  Fly   679 WPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQK-PGQEVITGHM 740

Human   655 ---------------TFR----------PTRK------------NSVP----------------- 665
                           |.:          ||:.            |:.|
  Fly   741 SKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDL 805

Human   666 VTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRR----- 725
            |||.......:|..|.| |.:|.:.:.:.:|  .||:...::.||:|.:.....::.:||
  Fly   806 VTSTNSLESGEDHPQAP-PETVAKSEATMQL--LIALITIIIVLNLLIYGTFLLRQRRRRAKALP 867

Human   726 -----------------HDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHE---------- 763
                             .:..:|||..|         ..::...|:|......:|
  Fly   868 FPAPKLGGTILSYDGANDEELKRCSKSR---------DGDDSFVLEMTRKSNTYEAIKTGQRSLS 923

Human   764 CESIHPHEVV--------------LRTACPP------DYTLAMRRSPD--DVPLMTPNTITMIPN 806
            |.::..|..|              ..||.||      |..|.:.:..:  |..|:.|..:.
  Fly   924 CSTVDTHTKVCEWMSSQEAPKSGSFNTATPPPQPILSDGRLIICQDIEVADAALLIPQHMH---- 984

Human   807 TIPGIQPLHTFNTFTGGQNNTLPHP--------HP---HPHSHS 839
                 :|.| :......|::.|..|        :|   |.||||
  Fly   985 -----EPQH-YEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHS 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	203/605 (34%)
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	203/604 (34%)