Protein Alignment NLGN1 and alpha-Est2

DIOPT Version :9

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 169/642 - (26%)
• Similarity: 268/642 - (41%)
• Gaps: 176/642 - (27%)

Human    38 LQAGHVLSQKLDDVDPLVATNFGKIRGIKKE--LNNEILGPVIQFLGVPYAAPPTGERRFQPPEP 100
            |..||.:         ::.|.:|::||::::  .:.|   |...|.|:|||.||.|:.||:.|:|
  Fly    27 LSTGHTV---------ILDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQP 79

Human   101 PSPWSDIRNAT--QFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTE 163
            |.||..:.|.|  :..|: .:|::.|                     :.:.|||||:||:||..
  Fly    80 PEPWQGVLNCTTNRSKPM-QRNMLLG---------------------IVEGSEDCLHLNVYVKA- 121

Human   164 DGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEG--TGNLYDGSVLASYGNVIVI 226
                                   ..|..|.||:|:|:||.:.:|  :.::|....... ..|:.:
  Fly   122 -----------------------LKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMK-KPVVFV 162

Human   227 TVNYRLGVLGFLSTGDQA--AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNL 289
            .:||||..|||||..|..  ..||.||.|.:.||||.|:||..|.|||..||:.|..||.:.|::
  Fly   163 AINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHV 227

Human   290 LTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSD-TVELVEC 353
            :..         :..|:|||.:||.|||.|||.| |......:|..||..:|....: ..:::..
  Fly   228 MMT---------TEQTRGLFHKAIMQSGCALSEW-VESPDNNWAFRLAQNLGYKGDEKDADVLSF 282

Human   354 LQKKPYKEL--VDQDI---QPARYHI--AFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLG 406
            |.|...:::  :|||:   ...|..:  ||||||     |..|:|...:.|:.:....:..:::|
  Fly   283 LSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVG 347

Human   407 VNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYP---------EGKDVLRETIKFMYTD 462
            .|..||| |...:|..|        .:|:.||.:.|   |         ||:|:|...:|.:|.:
  Fly   348 GNSFEGL-FSYQLVRKD--------PWALKNFHNIL---PREVRETSSLEGQDLLVRRLKQLYFN 400

Human   463 ---------------------WADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFY 506
                                 |.|.|      :.:||    .|..||...|.....:|.|| :|.
  Fly   401 NEMQESMEMFEALNIFSHRQIWHDTH------RFILA----RQSYAPKTPTYLYRFDFDSP-HFN 454

Human   507 AFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKT 569
            .|......|::   ...||.||:.|:.       ..:......|:.:....:  ::..||:||.:
  Fly   455 QFRRLVCGDRI---RGVAHADELSYLF-------YNIIASKLDKSSMEYKTIERMVGMWTSFASS 509

Human   570 GDPNQPVPQDTKF--IHTKPNRFEE-------------------VAWTRYSQKDQLY 605
            |:||.|.....|:  :..|.|..|:                   ..|..:..::.|:
  Fly   510 GNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPRESLF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	166/627 (26%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	161/592 (27%)
		Aes	<117..>221	CDD:223730	42/128 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740