Protein Alignment NLGN1 and alpha-Est3

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 156/616 - (25%)
• Similarity: 246/616 - (39%)
• Gaps: 147/616 - (23%)

Human    71 NEILGPV-------------IQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNII 122
            |...|||             :.|..:|||.||.|..||..|.|..|||...:.|:
  Fly     7 NTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK---------- 61

Human   123 DGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIR 187
            .|:.|  :....::..|:.|        |||||||:|....|.|
  Fly    62 PGQKP--LQFNHYSKQLEGV--------EDCLYLNVYAKELDSP--------------------- 95

Human   188 DSGGPKPVMVYIHGGSYMEG--TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQA--AKGN 248
               .|.|::|:..||.:.:|  |..|:..... ...:|:|:||:||:|.|||||..|.|  ..||
  Fly    96 ---RPLPLIVFFFGGGFEKGDPTKELHSPDYF-MMRDVVVVTVSYRVGPLGFLSLNDPAVGVPGN 156

Human   249 YGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAI 313
            .||.|.:.|:.|..||...|.|||..:|.||..||.:.|:.|.|:..:|         |||.:||
  Fly   157 AGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLMLNPKAE---------GLFHKAI 212

Human   314 AQSGTALSSWA---VSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHI- 374
            .|||..|.|||   :...|.:.|..|..:...:|:|.: :::.|||.|.::||...:..|..|:
  Fly   213 LQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAM-VLDFLQKLPGEKLVRPYLLSAEEHLD 276

Human   375 ----AFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASD 430
                .|||::     :...:|:.||.|:::.......:::.....|||.....:.
  Fly   277 DCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMYARVQ---------- 331

Human   431 FDFAVSNFVDNLYGYPEGK---DVLRETIKFMYTDWADR--------HNPETRRKTLLALFTDHQ 484
               .....:.:|...||..   ||.|...:.:......|        ::|.......|..:.::.
  Fly   332 ---MAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMSPESLKAYCEYA 393

Human   485 -----W----------VAPAVATADLHS-NFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVL 533
                 |          |..:.|:..|:. :|.|||:.:....:| .|::   ...||.|:..|:
  Fly   394 SYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYC-GDKL---RGVAHVDDHSYL- 453

Human   534 GIPMIGPTELFPCNFSKN--DVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWT 596
               ..|.   |.....|:  :.:....::...|:||:|.:||      .|.|..:..|.:|  |.
  Fly   454 ---WYGD---FSWKLDKHTPEFLTIERMIDMLTSFARTSNPN------CKLIQDQLPRAKE--WK 504

Human   597 RYSQKDQL-YLHIGLKPRVKEHYRANKVNLW 626
            ..:.|..| .|:|....::.|.....|:.:|
  Fly   505 PLNSKSALECLNISENIKMMELPELQKLRVW 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	155/614 (25%)
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	155/614 (25%)