Protein Alignment NLGN1 and alpha-Est4

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 178/641 - (27%)
• Similarity: 255/641 - (39%)
• Gaps: 183/641 - (28%)

Human    44 LSQKLDDVDPLVATNFGKIRGI-KKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDI 107
            :|...::..|:|.|..||:||| .|.|.:|   ....|.|:|||.||.|..||:.|....||..|
  Fly     1 MSDDYNEDAPVVQTTHGKVRGILLKSLYDE---QFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGI 62

Human   108 RNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQ--DQSEDCLYLNIYVPTEDGPLTKK 170
            |:.::....|.|                      ||:..:  :.|||||||||.|.|.
  Fly    63 RDCSKPLSKCLQ----------------------VSTLTKEVEGSEDCLYLNISVKTL------- 98

Human   171 QTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITV 228
                              :|.|.|||||||||::..|     |.|..| :|       ||:.|::
  Fly    99 ------------------NGDPMPVMVYIHGGAFKGG-----DSSRRA-WGPDYFMKENVVYISI 139

Human   229 NYRLGVLGFLSTGDQ--AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLT 291
            .:|||.|||||..|.  ...||.||.|:|.||||...|...|.|||.|||:||..:|...|.||.
  Fly   140 GHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPERITIFGHSSGSMTVQLLL 204

Human   292 LSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQK 356
            .|..||         |||.|||..:|.::....:.....:.|:.|..: |.||..  :::|.|.|
  Fly   205 ASPQSE---------GLFHRAILLAGFSMELNRLPQMEYRLAKHLGYE-GDNVDS--QVLEFLLK 257

Human   357 KPYKELVDQDI-----QPARYHIAFGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGE 411
            .....:|..|.     :...:::.|.|.|:....|:     :|..|..........|:||.|.||
  Fly   258 ADPALIVSADFFTPLEKRQGHNMPFKPSIESYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGE 322

Human   412 GLKFVENIVDSDDGISASDFDFAVSN--FVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRK 474
            |:               |.|.|...|  ::......||  .||..|::       :|.:|..||:
  Fly   323 GM---------------SIFSFVKMNPSWLKEFQCNPE--RVLPWTLR-------NRCDPGQRRQ 363

Human   475 T-----------------------LLALFTDHQWVAPAVATADLHSNFG-SPTYFYAF------- 508
            .                       |:.||| |.:|............:| :|||.|.|
  Fly   364 LGQALIHHFCEAHGHELTVDHTNGLVELFT-HGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDF 427

Human   509 -YHHCQ---TDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKT 569
             ::..:   .:|    ....|.||:.|:..:|     ..|..:.|:.:......::..:..||.|
  Fly   428 NFYRIRFMGKEQ----RGVGHVDELGYIFKLP-----ATFKLDKSRPEFTAIRRLVAMFVQFAAT 483

Human   570 GDPNQPVPQDTKFIHTKPNRFEEVAW---TRYSQKDQLYLHIGLK-------PRVK 615
            .|||.|:   ||.:         |.|   ||:.::..|.:...||       |::|
  Fly   484 SDPNAPL---TKSL---------VDWKPVTRFGKRMVLNISEELKFIPQPEMPKLK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	177/633 (28%)
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	177/634 (28%)