Protein Alignment NLGN1 and alpha-Est5

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001246965.1
• Gene: alpha-Est5 / 40905
• FlyBaseID: FBgn0261393
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 160/568 - (28%)
• Similarity: 243/568 - (42%)
• Gaps: 143/568 - (25%)

Human    60 GKIRGIKK-ELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIID 123
            |:|:|:|: .|.::   |...|..:|:|.||.||.||:.|.|..|||.:.:.|.:|....|.
  Fly    18 GQIKGVKRLSLYDD---PYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQR--- 76

Human   124 GRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRD 188
            |.|...:                 :..|||||||:|         .||.               .
  Fly    77 GLLTREI-----------------EGGEDCLYLNVY---------SKQL---------------K 100

Human   189 SGGPKPVMVYIHGGSYM--EGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAK--GNY 249
            |..|.||||||:||::.  |.|..|| |.......:|:::|:|||:..|||||..|.:.|  ||.
  Fly   101 SEKPLPVMVYIYGGAFTVGEATRELY-GPDYFMTKDVVLVTLNYRVDCLGFLSLKDPSLKVPGNA 164

Human   250 GLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIA 314
            ||.|.:.||:|..:.|..|.||...|||||..|||...:.:..         :..|:|||.:||.
  Fly   165 GLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHFMMC---------TEQTRGLFHKAIP 220

Human   315 QSGTALSSWAVSFQPAK-YARMLATKVG-CNVSDTVELVECLQKKPYKELVDQDIQPARYH---- 373
            .|||..:.||.:  ||: :|..||.:.| ...:|..:::|.||..|.::||:.::....:.
  Fly   221 MSGTVHNYWANN--PAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDLVNHNLLTPEHRRNGL 283

Human   374 -IAFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEG----------LKFVENIVDS 422
             .||||.::   |:  |:|..|..:.......|:.:|||....||          ||.::::  |
  Fly   284 LFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLGGTSFEGLFMYPAVSANLKALDSL--S 346

Human   423 DDGISASDFDF-AVSNFVDNL----------YGY-PEGKDVLRETIKF-MYTDWADRHNPETRRK 474
            .|.......|. .||:..:||          :|| |...::|...:.| .|..:....|     :
  Fly   347 QDPTRLVPVDVRTVSSEKENLEYSQRLMKAYFGYSPPSSELLLNMLDFYSYKIFWHGFN-----R 406

Human   475 TLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF--------YHHCQ--TDQVPAWADAAHGDEV 529
            |..|..|..:                :|||:|.|        ::..:  .|::.  ...||.|::
  Fly   407 TFNARLTYAK----------------APTYYYRFDFDSPNFNFYRAKFCGDKIK--TGVAHADDL 453

Human   530 PYVLGIPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP 575
            .|:  ....|..:|     .|.......:  ::..||.||.|.:||.|
  Fly   454 SYL--FRNAGSWKL-----DKTSAEYRTIERMIGIWTAFAATSNPNCP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	160/568 (28%)
alpha-Est5	NP_001246965.1	alpha/beta hydrolases	12..533	CDD:473884	160/568 (28%)