Protein Alignment NLGN1 and alpha-Est6

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 162/628 - (25%)
• Similarity: 240/628 - (38%)
• Gaps: 164/628 - (26%)

Human    46 QKLDDVD-PLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRN 109
            |...|.| .:|..:.|.::|  :.|:.........|.|:|:|.||.|:.||...:...||:...:
  Fly    33 QSAGDADSKVVKLSVGSVKG--RRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQLADPWNSELD 95

Human   110 ATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174
            |.|..|:..|  :|.|..:|:                  .||||||||:|.
  Fly    96 ARQERPIPLQ--MDRRSGKVV------------------GSEDCLYLNVYT-------------- 126

Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITVNYRL 232
                     :...:|..|.||||||:||::..|      |:|.:.||       :|:.:..||||
  Fly   127 ---------KHFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFNYRL 176

Human   233 GVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHY 295
            ..|||||  :|.....||.||.|.:.||:|.|::|..|.|||..||:||..||.:.|:.:..
  Fly   177 CSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMC--- 238

Human   296 SEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGC-NVSDTVELVECLQKKPY 359
                  ....||||.:||..||:.||.|..:.........|||..|. ..::.|.::|.|:....
  Fly   239 ------LPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRNVNA 297

Human   360 KELVDQDIQPAR-----YHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENI 419
            ::|:..|....|     :...|.||: |.::....|.||::.......::||....|||.:.. .
  Fly   298 EKLIGHDFISPRDRCFGFLNPFAPVV-GGLVAAPFQQLMKEAWSCEVPLLLGGTSFEGLVYYP-F 360

Human   420 VDSDDG---------------------ISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDW 463
            ...|:|                     :|..:.:.|....|...|| |.|  :.:..|
  Fly   361 CQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYG-PRG--ITKSNI------- 415

Human   464 ADRHNPETRRKTLLALFT-------DHQWVAPAVATADLHSNFGSPTYFYAF-----------YH 510
                      ..:|.||:       .|:.|...::.|.      :|||.|.|           ..
  Fly   416 ----------TQILDLFSYKLFWHGIHRVVLSRLSHAQ------APTYLYRFDFDSPKLNLMRNQ 464

Human   511 HCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP 575
            .|..|   ......|.|::.|:..........|....|.....|:..:     |.||:|||||.|
  Fly   465 LCGDD---IKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGIL-----TTFARTGDPNCP 521

Human   576 -------VPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLK 611
                   :|..||......|..::|......:||      |||
  Fly   522 ETGPDPWMPVSTKSPFKALNIGQQVECVTQVEKD------GLK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	160/622 (26%)
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	153/592 (26%)