Protein Alignment NLGN1 and alpha-Est7

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 579
• Identity: 159/579 - (27%)
• Similarity: 248/579 - (42%)
• Gaps: 132/579 - (22%)

Human    42 HVLSQKLDDVDPLVA--TNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPW 104
            |.:.|.....:..|.  |.:|::||||:....::  |...|.|:|||.||.||.||:.|:.|.||
  Fly    20 HKVQQYRQSTNETVVADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPW 82

Human   105 SDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTK 169
            ..:|:.:|     |:        :..:.|.|.  .|.|     :.||||||||:|.
  Fly    83 ERVRDCSQ-----PK--------DKAVQVQFV--FDKV-----EGSEDCLYLNVYT--------- 118

Human   170 KQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVIT 227
                    |:...|:       .:||||:||||.::.|..|      ...||       :|:::|
  Fly   119 --------NNVKPDK-------ARPVMVWIHGGGFIIGEAN------REWYGPDYFMKEDVVLVT 162

Human   228 VNYRLGVLGFLS--TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL 290
            :.||||.|||:|  :.:....||.||.|.:.||:|...|...|||||..|||||..|||:..:.:
  Fly   163 IQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITVFGESAGGASTHYM 227

Human   291 TLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWA----VSFQPAKYARMLATKVGCNVSDTVELV 351
            .|         ::.|:|||.|.|.|||:|:..||    ::..|.:.|:::..|...|..|.:|.
  Fly   228 ML---------TDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDVLEF- 282

Human   352 ECLQKKPYKEL--VDQDI-----QPARYHIAFGPVID-----GDVIPDDPQILMEQGEFLNYDIM 404
              ||....|:|  |::::     :..:...||||.::     ..||...|:.:|:.....:..:.
  Fly   283 --LQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNSIPMF 345

Human   405 LGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVL-RETIKFMYTDWA---- 464
            :|....|||.:|..:......:...|   |.:.|:.        |::| .|..|.....|:
  Fly   346 IGNTSYEGLLWVPEVKLMPQVLQQLD---AGTPFIP--------KELLATEPSKEKLDSWSAQIR 399

Human   465 --DRHNPETRRKTLLALFTDHQWVAPAVATADLHSNF----GSPTYFYAFYHHCQTDQVP----- 518
              .|...|:.....:.|.:.:.:|.||:..  :||..    |:|.|||.:....:....|
  Fly   400 DVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMR 462

Human   519 ---AWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMT--YWTNFAKTGDP 572
               .....:|.|::.|..       :.|......|.......:..|  .||.||.||:|
  Fly   463 LGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIERTVGIWTQFAATGNP 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	157/569 (28%)
alpha-Est7	NP_524261.1	COesterase	34..514	CDD:395084	155/563 (28%)