Protein Alignment NLGN1 and alpha-Est8

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 177/642 - (27%)
• Similarity: 262/642 - (40%)
• Gaps: 163/642 - (25%)

Human    46 QKLDDVDPLVA-TNFGKIRGIKKEL---NNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSD 106
            |:|...|.::| |.:||::|:|.:.   ||     ...|.|:|:|.||.||.||:.|..|..|||
  Fly    25 QRLRSNDKVIADTVYGKVKGVKWQSIYGNN-----YYSFEGIPFAKPPVGELRFKAPVEPEHWSD 84

Human   107 IRNATQF-APVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKK 170
            ::..|.. |..|..||:   |.:|                  ..||||||||:|
  Fly    85 VKRCTHVRAKPCQVNIV---LKQV------------------QGSEDCLYLNVY----------- 117

Human   171 QTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYM--EGTGNLYDGSVLASYGNVIVITVNYRLG 233
             |.:|..:            .|.||:|:|:||.:.  |.:.:||....: ...:|:::.::||||
  Fly   118 -TRELHPH------------RPLPVLVWIYGGGFQMGEASRDLYSPDYI-MMEHVVLVVISYRLG 168

Human   234 VLGFLSTGDQA--AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYS 296
            .|||||..|:.  ..||.||.|.:.||||...|..||||||..|||||..|||:..:.:.|
  Fly   169 ALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMML---- 229

Human   297 EGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVG----------------CNVS 345
                 ::..||||.:.|..||:||:.||.:.....:...||...|                |..|
  Fly   230 -----TDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFAHLKKCKAS 289

Human   346 DTVELVECLQKKPYKELVDQDIQPARYHI-AFGPVID-----GDVIPDDPQILMEQGEFLNYDIM 404
            ..:::.|        :::..:.:..|..: :|||.|:     ..|||..|..:|......:..::
  Fly   290 SMLKVAE--------DIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNSIPMV 346

Human   405 LGVNQGEGLKF----------------VENIVDSDDGISASDFDFAVSNFVDNLY---GYPEGKD 450
            :|.|..|||..                .||:...|..:...... |....|..||   ..|..|.
  Fly   347 IGGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQRK-AFGKKVRELYFGDRTPGRKT 410

Human   451 VLRETIKFMYT-DWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF---YHH 511
            :|..:..|.|. .|...|      :|||:  ..|.  ||.           :||:.|.|   ..|
  Fly   411 ILEYSDLFSYKYFWHGIH------RTLLS--RAHH--APL-----------APTFLYRFDFDSKH 454

Human   512 CQTDQVPAWA----DAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 572
            ....::....    ...|.|::.|:.........:.....|.....::|.||     :||.:|||
  Fly   455 FNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVV-----HFAISGDP 514

Human   573 NQP-VPQDTKFIHTKPNRFEEVAWTRYSQKDQLY--LHIGLKPRVKEHYRANKVNLW 626
            |.| |.||.|   .:|..    ||...|:.|:::  |:|.....|.:...|.|:.||
  Fly   515 NIPMVCQDEK---EQPRG----AWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	173/634 (27%)
alpha-Est8	NP_524259.2	COesterase	34..564	CDD:395084	172/631 (27%)