Protein Alignment NLGN1 and alpha-Est9

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 165/645 - (25%)
• Similarity: 257/645 - (39%)
• Gaps: 185/645 - (28%)

Human    54 LVATNFGKIRGIKKELNNEILG-PVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117
            :|:|.:|.|:|:|::   .|.| ....|..:|:|.||.||.|::.|:||..|:::|:.|...|..
  Fly    33 VVSTTYGPIKGVKRK---SIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKP 94

Human   118 PQN--IIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYV----PTEDGPLTKKQTDDLG 176
            .|.  :.:                      :.|.||||||||:|.    ||:
  Fly    95 LQKHFVFE----------------------MTDGSEDCLYLNVYTKNLYPTK------------- 124

Human   177 DNDGAEDEDIRDSGGPKPVMVYIHGGSYM--EGTGNLYDGSVLASYGNVIVITVNYRLGVL---- 235
                           |.||||:|:||.:.  |.:...|....|.. .:|:||::|||||.|
  Fly   125 ---------------PMPVMVWIYGGGFQFGEASRECYSPDYLLR-EDVVVISINYRLGPLGTND 173

Human   236 --------------GFLSTGDQA--AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGG 284
                          |||...|..  ..||.||.|.:.||||...|...||||...||:||..||.
  Fly   174 DTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGS 238

Human   285 SCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVG-CNVSDTV 348
            :.|:.:.:         :..|.|||.:||..||..||.|||:.| ..:...||.:.| ...::|.
  Fly   239 ASVHYMMI---------TEQTHGLFHKAICMSGNTLSPWAVTPQ-RNWPYRLAVQAGYAGENNTR 293

Human   349 ELVECLQKKPYKEL--------VDQDIQPARYHIAFGPVID-----GDVIPDDPQILMEQGEFLN 400
            ::.|.|:.....|:        :|:: :..|...:|||||:     ..|:|..|..:|......|
  Fly   294 DVWEFLKNAKGSEIIKANGELCIDEE-KKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNN 357

Human   401 YDIMLGVNQGEGLKFVE---------NIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETI 456
            ..:::|....|||....         |.:|....:...:.:....:.:...||     |.||:.
  Fly   358 IPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRESALCREYG-----DQLRQC- 416

Human   457 KFMYTDWADRHNP--ETRRKTLLALFTDHQWVAPAVAT--ADLHSNFGSPTYFYAF------YHH 511
              .|.|    ..|  :|..:.|..:..::.|. |...|  :.|.....:|||.|.|      ::|
  Fly   417 --YYGD----KTPSLDTLHEYLQMVSHEYFWF-PIYRTVLSRLQYARSAPTYLYRFDFDSKHFNH 474

Human   512 CQT----DQVPAWADAAHGDEVPYV----LGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAK 568
            .:.    .:|   ....|||::.|:    |...:...|..:.|        :..:| ..||:||.
  Fly   475 LRILSCGKKV---RGTCHGDDLSYLFYNSLARKLKNHTREYKC--------IERLV-GLWTHFAA 527

Human   569 TGDPN---------QPV---------------PQDTKFIHTKPNRFEEVAWTRYSQKDQL 604
            .|:||         |||               ..:.|.|.. |:..:.:.|..:.::|:|
  Fly   528 CGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDV-PDLKKLMVWESFFRRDEL 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	165/645 (26%)
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	162/634 (26%)