Protein Alignment NLGN1 and alpha-Est10

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 174/631 - (27%)
• Similarity: 248/631 - (39%)
• Gaps: 160/631 - (25%)

Human    54 LVATNFGKIRGIKKELNNEIL-GPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117
            ::.|..|.:||:|:   |.|. |....|..:|:|.||.|:.||:.||...||....:.|..|
  Fly    50 VIKTKSGPVRGVKR---NTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPA--- 108

Human   118 PQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAE 182
                 |..|...|.          ...|.  .||||||||:||       ...|.|.|
  Fly   109 -----DKPLQTHMF----------FRKYA--GSEDCLYLNVYV-------KDLQPDKL------- 142

Human   183 DEDIRDSGGPKPVMVYIHGGSYM--EGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQA- 244
                      :||||:|:||.|.  |.:.::|......| .:|:::||.||||.|||||..|..
  Fly   143 ----------RPVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGFLSLDDPQL 196

Human   245 -AKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGL 308
             ..||.||.|.|.||||..:||..||||...||:||..|||:..:.|.|         |..|:||
  Fly   197 NVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLAL---------SPQTEGL 252

Human   309 FQRAIAQSGTALSSWAVSFQPAK--YARMLATKVGCNVSDTVELV-ECLQKKPYKELV------- 363
            ..:||..||:.|..|.   ||.:  :|..||.|:|....:..:.: |.|:.....|:|
  Fly   253 IHKAIVMSGSVLCPWT---QPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVL 314

Human   364 DQDIQPARYHIAFGPVI-----DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKF-------- 415
            ..|.:..|...|||||:     :..|:...|..||:........:|.|....|||.|
  Fly   315 SNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRP 379

Human   416 --------VENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRET----IKFMYTDWADRHN 468
                    .:|::.||.|::..                |:    |||.    :|..|  :.|...
  Fly   380 ATLDEVGNCKNLLPSDLGLNLD----------------PK----LRENYGLQLKKAY--FGDEPC 422

Human   469 PETRRKTLLALFTDHQWVAPAV-ATADLHSNFGSPTYFYAFYHH---CQTDQV----PAWADAAH 525
            .:......|.|.:..::..|.. |..:......:|||.|.|.|.   |...::    .......|
  Fly   423 NQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRGVCH 487

Human   526 GDEVPYVLGIPM---IGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF--IHT 585
            ||::.|:....:   ..|.       |....:::.:| ..||:||..||||....:..||  |..
  Fly   488 GDDLCYIFHSMLSHQSAPD-------SPEHKVITGMV-DVWTSFAAHGDPNCESIKSLKFAPIEN 544

Human   586 KPN--------RFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKV 623
            ..|        :||.:|.....:         ::|.....|..||:
  Fly   545 VTNFKCLNIGDQFEVMALPELQK---------IEPVWNSFYAPNKL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	174/631 (28%)
alpha-Est10	NP_001246962.1	COesterase	49..533	CDD:395084	163/572 (28%)