Protein Alignment NLGN1 and Est-Q

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 155/602 - (25%)
• Similarity: 251/602 - (41%)
• Gaps: 137/602 - (22%)

Human    23 RGLGAPLTLC-MLGCLLQAGHVL----SQKLDDVDPLVATNFGKIRGIKKELNN---EILG---- 75
            ||:...|||| :|...|.|..|:    .|..|..:....|         .||.|   .:||
  Fly     4 RGVYVMLTLCGVLTAGLTAFLVIFLTGGQGADASETATVT---------VELYNGQGTVLGNYAY 59

Human    76 ------PVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVW 134
                  ..:||.|:|:|.||..|.||:||...|||:...||..|...||
  Fly    60 TAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP---------------- 108

Human   135 FTNNLDVVSSYVQD-QSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVY 198
            ...|||   |.:.| :.||||.|::|.                          ::....:|||.|
  Fly   109 VITNLD---SQMSDAELEDCLTLSVYT--------------------------KNLSASQPVMFY 144

Human   199 IHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSE 263
            |:||.:..|:...:..:.|.. .:|:::...||:|.||:|||..:...||..:.|::.||.|...
  Fly   145 IYGGGFYNGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQM 208

Human   264 NIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ 328
            :|..|||||.::|:||..||....:.|.||..:..|        :|:|||.|||:..:|||::..
  Fly   209 HISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDN--------MFKRAIVQSGSIFASWAINKD 265

Human   329 PAKYARMLATKVGCN-VSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGD---VIPDDP 389
            |...:|.:..::||: .....:||:|:||   .:::  ||..|....:|.|:: ||   ::|..|
  Fly   266 PKAQSRRICIQLGCSGCEQHDQLVKCIQK---AKVI--DILKATASESFSPIV-GDLHGILPQQP 324

Human   390 QILMEQGEFLNY----DIMLGVNQGEGLKFVENIVD-------SDDGISASDFDFAVSNFVDNLY 443
            ..|::     :|    .|:.|..|.:|...:.:..|       :...:|...|...:::.|::..
  Fly   325 SELVK-----SYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTS 384

Human   444 GYPEGKDVLRETIKFMYTDWA-DRHNPETRRKTLLALFTDHQWVAPAV--ATADLHSNFGSPTYF 505
            |..:  ::|.   :.::...| :.|:......:...|.|:....:|.:  ||........:|.|.
  Fly   385 GLTD--NILN---RLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYV 444

Human   506 YAF-YHHCQT--------DQVPAWADAAHGDEVPYVLGI-PMIGPTELFPCNFSKNDVMLSAVVM 560
            |:| |....|        ...|......|.::..|:... |:.|           .|..:|..::
  Fly   445 YSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMV 498

Human   561 TYWTNFAKTGDPNQPVP 577
            ..||:||..|.|....|
  Fly   499 DVWTSFAIEGVPRNLSP 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	143/568 (25%)
Est-Q	NP_649321.1	COesterase	50..536	CDD:395084	139/547 (25%)