DRSC/TRiP Functional Genomics Resources

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Protein Alignment NLGN1 and Nrt

DIOPT Version :10

Sequence 1:NP_001352852.1 Gene:NLGN1 / 22871 HGNCID:14291 Length:843 Species:Homo sapiens
Sequence 2:NP_476798.1 Gene:Nrt / 39873 FlyBaseID:FBgn0004108 Length:846 Species:Drosophila melanogaster


Alignment Length:411 Identity:114/411 - (27%)
Similarity:162/411 - (39%) Gaps:114/411 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    19 CLVHRGL---GAPLTLCMLGCLLQAGHVLSQKLDDVDPL-------VATNFGKIRGIKKELNNEI 73
            |.|...|   |..|.:.:||.:   |:||:.:.....||       ..|..|.:.|:|::     
  Fly   320 CSVDDALIVFGILLFVLLLGVI---GYVLTHETLTSPPLREGRYIMAVTGCGPVEGVKED----- 376

Human    74 LGPVIQFLGVPYAAPPTGERRFQPPEPPSP----WSDIRNATQFAPVCPQNIIDGRLPEVMLPVW 134
              ....|.|:|||.||....|::|.|....    |:|.......:.||.|.:.:|          
  Fly   377 --GAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNG---------- 429

Human   135 FTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYI 199
                     :.|.|  ||||||::..|                       .:| ...|.||:|.|
  Fly   430 ---------TTVGD--EDCLYLDVVTP-----------------------HVR-YNNPLPVVVLI 459

Human   200 HGGSYMEG--TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAK-------GNYGLLDLI 255
             |...:.|  .|.|...:..:...:||.:..|:||||.|||:. |...|       |||.|.|:|
  Fly   460 -GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLAL-DALTKEAHPPTSGNYALTDII 522

Human   256 QALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTAL 320
            ..|.|...||..|||||..:|:.|..||.:.|.||..         |...|||:.||.|.||:|:
  Fly   523 AVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVN---------SQKVKGLYTRAWASSGSAI 578

Human   321 SSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKEL------------VDQDIQPARYH 373
            .......:..|....|...:.|  :|    ::||::...:.|            ||.. ||...:
  Fly   579 LPGKPLSESGKQNEQLMATLEC--AD----IQCLREASSERLWAATPDTWLHFPVDLP-QPQEAN 636

Human   374 IAFGP-----VIDGDVIPDDP 389
             |.|.     |:||||:.:.|
  Fly   637 -ASGSRHEWLVLDGDVVFEHP 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NLGN1NP_001352852.1 COesterase 52..626 CDD:395084 104/375 (28%)
NrtNP_476798.1 PTZ00121 <3..>222 CDD:173412
alpha/beta hydrolases 362..832 CDD:473884 102/366 (28%)
Blue background indicates that the domain is not in the aligned region.

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