Protein Alignment NLGN1 and Est-P

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 164/580 - (28%)
• Similarity: 235/580 - (40%)
• Gaps: 159/580 - (27%)

Human    50 DVDPLVA--TNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPS-PWSDIRNAT 111
            :.|||:.  || |||||...       |....:..:|.|..|||..||:.|:|.| .|:|:.|||
  Fly    21 EADPLIVEITN-GKIRGKDN-------GLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNAT 77

Human   112 QFAPVCPQNIIDGRLPEVMLPVW--FTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174
            |....|.|              |  |.|..:.:..     .||||.::||.|       ||..
  Fly    78 QSPVECMQ--------------WNQFINENNKLMG-----DEDCLTVSIYKP-------KKPN-- 114

Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239
                        |.|   .||:|.:|||::|.|:|::|....:...|.::|:.:::.||.|||.|
  Fly   115 ------------RSS---FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFAS 164

Human   240 TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTL----SHYSEGNR 300
            |||:...|||||.|...||:|..:||..|||.|..|.:.|..|||:..:|..|    .|.::|
  Fly   165 TGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKG-- 227

Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGC---NVSDTVELVECLQKKPYKEL 362
                       ||:.||.||..|.:.....:.|..|...|||   |||  .||.:||:.||..::
  Fly   228 -----------AISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVS--AELKDCLKSKPASDI 279

Human   363 VDQDIQPARYHI--------AFGPVIDGDVIPD-----DPQILMEQGEFLNYDIML-------GV 407
            |    ...|..:        |||||::....||     ||:.:::.|:|......:       |.
  Fly   280 V----SAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGY 340

Human   408 NQGEGLKFVENIVDSDDGISASD---FDFAVSNFVDNLYGYPEGKDVLRE------TIKFMYTDW 463
            |..:.|:  .|.:..:..|...:   ||:|     ..|..|.:.|..:::      .::..|.
  Fly   341 NAAQLLE--RNKLTGESWIDLLNDRWFDWA-----PYLLFYRDAKKTIKDMDDLSFDLRQQYL-- 396

Human   464 ADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFG-SPTYFYAFYHHCQTD---------QVP 518
            |||.........:..:|||..:.....:..|||..:| ||.  |:|.:...||         :..
  Fly   397 ADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPV--YSFVYDNPTDSGVGQLLSNRTD 459

Human   519 AWADAAHGDE-------VPYVLGI---------PMIGPTELF-----------PCNFSKN 551
            ......|||:       ..|..||         ..||..|.|           .|||..|
  Fly   460 VHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNN 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	164/578 (28%)
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	161/575 (28%)