Protein Alignment NLGN1 and Est-6

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 581
• Identity: 160/581 - (27%)
• Similarity: 235/581 - (40%)
• Gaps: 130/581 - (22%)

Human    10 NYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDP-LVATNFGKIRGIKKELNNEI 73
            |||           |||   .:.:|.||...    |...|..|| ||....||:||...
  Fly     2 NYV-----------GLG---LIIVLSCLWLG----SNASDTDDPLLVQLPQGKLRGRDN------ 42

Human    74 LGPVIQFLGVPYAAPPTGERRFQPPEP-PSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVW--F 135
             |....:..:|||.||||:.||:.||| ...||||.:||:....|.|              |  |
  Fly    43 -GSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ--------------WDQF 92

Human   136 TNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIH 200
            |...:.:..     .||||.:::|.|..    :|:.:                    .||:.:||
  Fly    93 TPGANKLVG-----EEDCLTVSVYKPKN----SKRNS--------------------FPVVAHIH 128

Human   201 GGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENI 265
            ||::|.|.........:...|..|::.::||||.|||:||||:...|||||.|...||:|..:||
  Fly   129 GGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNI 193

Human   266 GFFGGDPLRITVFGSGAGGSCVNLLTL-SHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQP 329
            ..|||:|..:.:.|..|||:.|:|..| ..:.:          |.:.|.:.||.||..|.:....
  Fly   194 ASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQ----------LARAAFSFSGNALDPWVIQKGA 248

Human   330 AKYARMLATKVGC-NVSDTVELVECLQKKPYKELVDQDIQPARYHI-------AFGPVIDGDVIP 386
            ...|..|...||| :..|:..|.:||:.||..|||   ....::.|       .|.||::....|
  Fly   249 RGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV---TAVRKFLIFSYVPFAPFSPVLEPSDAP 310

Human   387 D-----DPQILMEQGEF------LNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVD 440
            |     ||:.:::.|:|      ::|     |.:..|......:.:...||...|.:........
  Fly   311 DAIITQDPRDVIKSGKFGQVPWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAP 370

Human   441 NLYGYPEGK-----DVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFG 500
            .|..|.:.|     |.....||..|.. ..|.:.|:..: |..||||..:......:.|||..:|
  Fly   371 YLLFYRDTKTKKDMDDYSRKIKQEYIG-NQRFDIESYSE-LQRLFTDILFKNSTQESLDLHRKYG 433

Human   501 -SPTYFYAFYHHCQTDQVPAWAD-------AAHGDEV-----PYVLGIPMIGPTELFPCNF 548
             ||.|.|.:.:..:.......|:       ..|||:.     .:|..:.|....::...||
  Fly   434 KSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNF 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	149/539 (28%)
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	147/536 (27%)