Protein Alignment NLGN1 and gas

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 183/631 - (29%)
• Similarity: 262/631 - (41%)
• Gaps: 179/631 - (28%)

Human    55 VATNFGKIRGIKKE--LNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117
            :||.:|:::|.::.  .:.|   |...|.|:|:|.||.||.||:.|:|||.|..:|:.| :|...
  Fly    35 LATKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT-YAREK 95

Human   118 P--QNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDG 180
            |  :|.|             ||        ..:.||||||||:|....:.|
  Fly    96 PMQRNSI-------------TN--------AAEGSEDCLYLNVYAKRLESP-------------- 125

Human   181 AEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITVNYRLGVLGFL 238
                      .|.||||:|.||.:..|      |:....||       :::::|:|||:||||||
  Fly   126 ----------KPLPVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFL 174

Human   239 STGDQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRW 301
            |..|:..|  ||.||.|.||||||..|||..|.|||..|||||..|||:..::|         ..
  Fly   175 SLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHIL---------MQ 230

Human   302 SNSTKGLFQRAIAQSGTALSSWAVSFQP-AKYARMLATKVGC--NVSDTVELVECLQKKPYKEL- 362
            :...:|||.|||.|||:||.:||.  || .|:.:.|..::|.  |:....||:|..|:.|..:|
  Fly   231 TEQARGLFHRAIVQSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLA 293

Human   363 ------VDQDIQPARYHIAFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV 416
                  |.|:.|.....:||.|||:   ||  |||...|..:......:..:::|....|||...
  Fly   294 QYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSY 358

Human   417 ENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTD------------------- 462
            ...:| |.....|.|:..:...|.:.....|..:::|...|..:.|
  Fly   359 RTTLD-DPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKN 422

Human   463 -WADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF------YHHCQT----DQ 516
             |.|.|      :||||..        |.||       ..|||.|.|      ::|.:.    .:
  Fly   423 FWHDIH------RTLLARL--------AYAT-------NLPTYLYRFDMDSPHFNHYRILKCGKK 466

Human   517 VPAWADAAHGDEVPYVL-GIPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQ 578
            |   ....|.|::.|:. ||        ......||......:  ::..||:||.|||||..:..
  Fly   467 V---RGVCHADDISYMFYGI--------LSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIA 520

Human   579 DTKFIHTKPNRFEE-------------------VAWTRYSQKDQLY 605
            ..|:...:|...|.                   |.|..:..::.||
  Fly   521 PVKWDPLRPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	183/631 (29%)
gas	NP_611678.1	COesterase	31..529	CDD:395084	177/592 (30%)