Protein Alignment NLGN1 and Jhe

DIOPT Version :10

• Sequence 1: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 184/674 - (27%)
• Similarity: 279/674 - (41%)
• Gaps: 166/674 - (24%)

Human    29 LTLCMLGCLLQAGHVLSQKLDDVDPLV----------ATNFGKIRGIKKELNNEILGPVIQFLGV 83
            |.|.:||.||.........|..||.|.          .||   ::|.:.|...       .|:|:
  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTN---LQGYQSERFE-------AFMGI 61

Human    84 PYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQ--NIIDGRLPEV-------MLPVWFTNNL 139
            |||.||.|:.||..|:                |.|:  .:.|...|::       :||.
  Fly    62 PYALPPIGDLRFSNPK----------------VMPKLLGMYDASAPKMDCIQKNYLLPT------ 104

Human   140 DVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSY 204
            .||..     .|||||||:|.|                       :||.|.  .|||||||||.:
  Fly   105 PVVYG-----DEDCLYLNVYRP-----------------------EIRKSA--LPVMVYIHGGGF 139

Human   205 MEG------TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSE 263
            ..|      ||..|    ....|.||::|:.||||..|||||.|....||:||.|...||||...
  Fly   140 FGGSAGPGVTGPEY----FMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQR 200

Human   264 NIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ 328
            ||.||||||.|:|:||..|||...::..||..|.         |||.|.|:.||||...:|::.|
  Fly   201 NIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSH---------GLFHRVISMSGTANVPFAIAEQ 256

Human   329 PAKYARMLATKVGCNVSD-----TVELVECLQKKPYKELVDQ-------DIQPARYHIA-FGPVI 380
            |.:.||:||.  ..:|.|     ||:|.:.|::....:|::.       |:.    |:. |.||:
  Fly   257 PLEQARLLAE--FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVV 315

Human   381 DGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVD 440
            :..:..|     .|..::.||...:..::||...|||...|.||:.::  .....|:......:.
  Fly   316 EEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQ 378

Human   441 NLYGYP-----EGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNF- 499
            .|..:|     :.::.:.:.:..:|.......| |...:..:.|.:|..:..|...|  :|.|.
  Fly   379 ELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVC 440

Human   500 --GSPTYFYAFYHHCQTDQVPAWADA--------AHGDEVPYVLGIPMIGPTELFPCNFSKNDVM 554
              .:|.|.|:|.:........|:..|        .|.|::.|:...|:     ||| :|.:|...
  Fly   441 HTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTE 499

Human   555 LSAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRV 614
            ...:  .:.|:.:|||.|.|...   .|...:.:.::|:...:  :..::.....|.  |.:..|
  Fly   500 AKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICD--YHEFANAPDAYQ--GFEVHV 560

Human   615 KEHYRANKVNLWLELVPHLHNLND 638
            ...::.::||||      .|.||:
  Fly   561 ASEFQTDRVNLW------SHILNE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	171/637 (27%)
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	162/580 (28%)